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Comorbidity and survival in the pre-hospital and in-hospital phase after out-of-hospital cardiac arrest. / Oving, Iris; van Dongen, Laura H. P. I.; Deurholt, Suzanne C. et al.

In: Resuscitation, Vol. 153, 01.08.2020, p. 58-64.

Research output: Contribution to journal › Article › Academic › peer-review

Harvard

Oving, I, van Dongen, LHPI, Deurholt, SC, Ramdani, A, Beesems, SG, Tan, HL & Blom, MT 2020, 'Comorbidity and survival in the pre-hospital and in-hospital phase after out-of-hospital cardiac arrest', Resuscitation, vol. 153, pp. 58-64. https://doi.org/10.1016/j.resuscitation.2020.05.035

APA

Oving, I., van Dongen, L. H. P. I., Deurholt, S. C., Ramdani, A., Beesems, S. G., Tan, H. L., & Blom, M. T. (2020). Comorbidity and survival in the pre-hospital and in-hospital phase after out-of-hospital cardiac arrest. Resuscitation, 153, 58-64. https://doi.org/10.1016/j.resuscitation.2020.05.035

Vancouver

Oving I, van Dongen LHPI, Deurholt SC, Ramdani A, Beesems SG, Tan HL et al. Comorbidity and survival in the pre-hospital and in-hospital phase after out-of-hospital cardiac arrest. Resuscitation. 2020 Aug 1;153:58-64. doi: 10.1016/j.resuscitation.2020.05.035

Author

Oving, Iris ; van Dongen, Laura H. P. I. ; Deurholt, Suzanne C. et al. / Comorbidity and survival in the pre-hospital and in-hospital phase after out-of-hospital cardiac arrest. In: Resuscitation. 2020 ; Vol. 153. pp. 58-64.

BibTeX

@article{e89eba1f2da5449fb877e254bb1b1d6d,
title = "Comorbidity and survival in the pre-hospital and in-hospital phase after out-of-hospital cardiac arrest",
abstract = "Introduction: Cumulative disease burden may be associated with survival chances after out-of-hospital cardiac arrest (OHCA). The relative contributions of cumulative disease burden on survival rates at the pre-hospital and in-hospital phases of post-resuscitation care are unknown. Methods: The association between cumulative comorbidity burden as measured by the Charlson Comorbidity Index (CCI) and pre-hospital and in-hospital survival rates was studied using data (2010–2014) from a prospective OHCA registry in the Netherlands. The association between CCI and survival rate (overall survival [OHCA-hospital discharge], pre-hospital survival [OHCA-hospital admission] and in-hospital survival [hospital admission-hospital discharge]) was assessed using logistic regression analyses. The relative contributions of CCI on pre-hospital and in-hospital survival rates were determined using the Nagelkerke test. Results: We included 2510 OHCA patients aged ≥18y. CCI was significantly associated with overall survival rate (OR 0.71; 95%CI 0.61−0.83; P < 0.01). CCI was not associated with pre-hospital survival rate (OR 0.96; 95%CI 0.76–1.23; P = 0.92) whereas high CCI was significantly associated with low in-hospital survival rate (OR 0.41; 95%CI 0.27−0.62; P = 0.01). The relative contributions of CCI on pre-hospital and in-hospital survival were 1.1% and 8.1%, respectively. Conclusion: Pre-existing high comorbidity burden plays a modest role in reducing survival rate after OHCA, and only in the in-hospital phase. The present study offers data that may guide clinicians in discussing resuscitation options during advance care planning with patients with high comorbidity burden. This may be helpful in creating a patients{\textquoteright} informed choice.",
keywords = "Charlson Comorbidity Index, Comorbidity, ESCAPE-NET, In-hospital, Out-of-hospital cardiac arrest, Pre-hospital, Survival",
author = "Iris Oving and {van Dongen}, {Laura H. P. I.} and Deurholt, {Suzanne C.} and Amal Ramdani and Beesems, {Stefanie G.} and Tan, {Hanno L.} and Blom, {M. T.}",
year = "2020",
month = aug,
day = "1",
doi = "10.1016/j.resuscitation.2020.05.035",
language = "English",
volume = "153",
pages = "58--64",
journal = "Resuscitation",
issn = "0300-9572",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Comorbidity and survival in the pre-hospital and in-hospital phase after out-of-hospital cardiac arrest

AU - Oving, Iris

AU - van Dongen, Laura H. P. I.

AU - Deurholt, Suzanne C.

AU - Ramdani, Amal

AU - Beesems, Stefanie G.

AU - Tan, Hanno L.

AU - Blom, M. T.

PY - 2020/8/1

Y1 - 2020/8/1

N2 - Introduction: Cumulative disease burden may be associated with survival chances after out-of-hospital cardiac arrest (OHCA). The relative contributions of cumulative disease burden on survival rates at the pre-hospital and in-hospital phases of post-resuscitation care are unknown. Methods: The association between cumulative comorbidity burden as measured by the Charlson Comorbidity Index (CCI) and pre-hospital and in-hospital survival rates was studied using data (2010–2014) from a prospective OHCA registry in the Netherlands. The association between CCI and survival rate (overall survival [OHCA-hospital discharge], pre-hospital survival [OHCA-hospital admission] and in-hospital survival [hospital admission-hospital discharge]) was assessed using logistic regression analyses. The relative contributions of CCI on pre-hospital and in-hospital survival rates were determined using the Nagelkerke test. Results: We included 2510 OHCA patients aged ≥18y. CCI was significantly associated with overall survival rate (OR 0.71; 95%CI 0.61−0.83; P < 0.01). CCI was not associated with pre-hospital survival rate (OR 0.96; 95%CI 0.76–1.23; P = 0.92) whereas high CCI was significantly associated with low in-hospital survival rate (OR 0.41; 95%CI 0.27−0.62; P = 0.01). The relative contributions of CCI on pre-hospital and in-hospital survival were 1.1% and 8.1%, respectively. Conclusion: Pre-existing high comorbidity burden plays a modest role in reducing survival rate after OHCA, and only in the in-hospital phase. The present study offers data that may guide clinicians in discussing resuscitation options during advance care planning with patients with high comorbidity burden. This may be helpful in creating a patients’ informed choice.

AB - Introduction: Cumulative disease burden may be associated with survival chances after out-of-hospital cardiac arrest (OHCA). The relative contributions of cumulative disease burden on survival rates at the pre-hospital and in-hospital phases of post-resuscitation care are unknown. Methods: The association between cumulative comorbidity burden as measured by the Charlson Comorbidity Index (CCI) and pre-hospital and in-hospital survival rates was studied using data (2010–2014) from a prospective OHCA registry in the Netherlands. The association between CCI and survival rate (overall survival [OHCA-hospital discharge], pre-hospital survival [OHCA-hospital admission] and in-hospital survival [hospital admission-hospital discharge]) was assessed using logistic regression analyses. The relative contributions of CCI on pre-hospital and in-hospital survival rates were determined using the Nagelkerke test. Results: We included 2510 OHCA patients aged ≥18y. CCI was significantly associated with overall survival rate (OR 0.71; 95%CI 0.61−0.83; P < 0.01). CCI was not associated with pre-hospital survival rate (OR 0.96; 95%CI 0.76–1.23; P = 0.92) whereas high CCI was significantly associated with low in-hospital survival rate (OR 0.41; 95%CI 0.27−0.62; P = 0.01). The relative contributions of CCI on pre-hospital and in-hospital survival were 1.1% and 8.1%, respectively. Conclusion: Pre-existing high comorbidity burden plays a modest role in reducing survival rate after OHCA, and only in the in-hospital phase. The present study offers data that may guide clinicians in discussing resuscitation options during advance care planning with patients with high comorbidity burden. This may be helpful in creating a patients’ informed choice.

KW - Charlson Comorbidity Index

KW - Comorbidity

KW - ESCAPE-NET

KW - In-hospital

KW - Out-of-hospital cardiac arrest

KW - Pre-hospital

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=85086699864&partnerID=8YFLogxK

U2 - 10.1016/j.resuscitation.2020.05.035

DO - 10.1016/j.resuscitation.2020.05.035

M3 - Article

C2 - 32502577

VL - 153

SP - 58

EP - 64

JO - Resuscitation

JF - Resuscitation

SN - 0300-9572

ER -

ID: 12043615