Standard

Clinical outcome after repeated radiosurgery for brain arteriovenous malformations. / Buis, Dennis R.; Meijer, Otto W. M.; van den Berg, René et al.

In: Radiotherapy and oncology, Vol. 95, No. 2, 2010, p. 250-256.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

Buis, DR, Meijer, OWM, van den Berg, R, Lagerwaard, FJ, Bot, JCJ, Slotman, BJ & Vandertop, WP 2010, 'Clinical outcome after repeated radiosurgery for brain arteriovenous malformations', Radiotherapy and oncology, vol. 95, no. 2, pp. 250-256. https://doi.org/10.1016/j.radonc.2010.03.003

APA

Buis, D. R., Meijer, O. W. M., van den Berg, R., Lagerwaard, F. J., Bot, J. C. J., Slotman, B. J., & Vandertop, W. P. (2010). Clinical outcome after repeated radiosurgery for brain arteriovenous malformations. Radiotherapy and oncology, 95(2), 250-256. https://doi.org/10.1016/j.radonc.2010.03.003

Vancouver

Buis DR, Meijer OWM, van den Berg R, Lagerwaard FJ, Bot JCJ, Slotman BJ et al. Clinical outcome after repeated radiosurgery for brain arteriovenous malformations. Radiotherapy and oncology. 2010;95(2):250-256. https://doi.org/10.1016/j.radonc.2010.03.003

Author

Buis, Dennis R. ; Meijer, Otto W. M. ; van den Berg, René et al. / Clinical outcome after repeated radiosurgery for brain arteriovenous malformations. In: Radiotherapy and oncology. 2010 ; Vol. 95, No. 2. pp. 250-256.

BibTeX

@article{c3192f0494064d65b175c4a8d337ba4a,
title = "Clinical outcome after repeated radiosurgery for brain arteriovenous malformations",
abstract = "Introduction: We assessed the clinical and radiological outcome after repeated radiosurgery for brain arteriovenous malformations (bAVMs) after failure of initial radiosurgery. Materials and methods: Fifteen patients underwent repeated radiosurgery. The mean bAVM volume at first radiosurgery (Si) was 4.6 +/- 4.3 ml and that at second radiosurgery (52) was 2.1 +/- 2.5 ml. The median marginal dose was 18 Gy at S1, and 21 Gy at S2. Modified Rankin Scale (MRS) score was determined in all patients at last follow-up (FU). Results: Complete obliteration was reached in nine patients (60%). Median time to obliteration was 50 months after S2. An excellent outcome (no new neurologic deficiencies, complete obliteration) was reached in seven patients (47%). Eleven patients (73%) showed a MRS <= 1. Radiation-induced complications occurred in 20%, of which 13% occurred after S2. Radiological complications included cyst formation (n = 1), radiation-related edema (n = 4), and radiation necrosis (n = 1), resulting in an increasing mean MRS of 0.5 at S1, 0.6 at S2, to 0.8 at FU. No (re-)bleedings were encountered during 137-patient years at risk. Discussion: Repeated radiosurgery is a viable option for the treatment of small remnant bAVMs. We report 20% permanent radiation-induced complications. Such complications were mainly seen in relatively large, and therefore difficult to treat, bAVMs. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 95 (2010) 250-256",
author = "Buis, {Dennis R.} and Meijer, {Otto W. M.} and {van den Berg}, Ren{\'e} and Lagerwaard, {Frank J.} and Bot, {Joost C. J.} and Slotman, {Ben J.} and Vandertop, {W. Peter}",
year = "2010",
doi = "10.1016/j.radonc.2010.03.003",
language = "English",
volume = "95",
pages = "250--256",
journal = "Radiotherapy and oncology",
issn = "0167-8140",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Clinical outcome after repeated radiosurgery for brain arteriovenous malformations

AU - Buis, Dennis R.

AU - Meijer, Otto W. M.

AU - van den Berg, René

AU - Lagerwaard, Frank J.

AU - Bot, Joost C. J.

AU - Slotman, Ben J.

AU - Vandertop, W. Peter

PY - 2010

Y1 - 2010

N2 - Introduction: We assessed the clinical and radiological outcome after repeated radiosurgery for brain arteriovenous malformations (bAVMs) after failure of initial radiosurgery. Materials and methods: Fifteen patients underwent repeated radiosurgery. The mean bAVM volume at first radiosurgery (Si) was 4.6 +/- 4.3 ml and that at second radiosurgery (52) was 2.1 +/- 2.5 ml. The median marginal dose was 18 Gy at S1, and 21 Gy at S2. Modified Rankin Scale (MRS) score was determined in all patients at last follow-up (FU). Results: Complete obliteration was reached in nine patients (60%). Median time to obliteration was 50 months after S2. An excellent outcome (no new neurologic deficiencies, complete obliteration) was reached in seven patients (47%). Eleven patients (73%) showed a MRS <= 1. Radiation-induced complications occurred in 20%, of which 13% occurred after S2. Radiological complications included cyst formation (n = 1), radiation-related edema (n = 4), and radiation necrosis (n = 1), resulting in an increasing mean MRS of 0.5 at S1, 0.6 at S2, to 0.8 at FU. No (re-)bleedings were encountered during 137-patient years at risk. Discussion: Repeated radiosurgery is a viable option for the treatment of small remnant bAVMs. We report 20% permanent radiation-induced complications. Such complications were mainly seen in relatively large, and therefore difficult to treat, bAVMs. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 95 (2010) 250-256

AB - Introduction: We assessed the clinical and radiological outcome after repeated radiosurgery for brain arteriovenous malformations (bAVMs) after failure of initial radiosurgery. Materials and methods: Fifteen patients underwent repeated radiosurgery. The mean bAVM volume at first radiosurgery (Si) was 4.6 +/- 4.3 ml and that at second radiosurgery (52) was 2.1 +/- 2.5 ml. The median marginal dose was 18 Gy at S1, and 21 Gy at S2. Modified Rankin Scale (MRS) score was determined in all patients at last follow-up (FU). Results: Complete obliteration was reached in nine patients (60%). Median time to obliteration was 50 months after S2. An excellent outcome (no new neurologic deficiencies, complete obliteration) was reached in seven patients (47%). Eleven patients (73%) showed a MRS <= 1. Radiation-induced complications occurred in 20%, of which 13% occurred after S2. Radiological complications included cyst formation (n = 1), radiation-related edema (n = 4), and radiation necrosis (n = 1), resulting in an increasing mean MRS of 0.5 at S1, 0.6 at S2, to 0.8 at FU. No (re-)bleedings were encountered during 137-patient years at risk. Discussion: Repeated radiosurgery is a viable option for the treatment of small remnant bAVMs. We report 20% permanent radiation-induced complications. Such complications were mainly seen in relatively large, and therefore difficult to treat, bAVMs. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 95 (2010) 250-256

U2 - 10.1016/j.radonc.2010.03.003

DO - 10.1016/j.radonc.2010.03.003

M3 - Article

C2 - 20362350

VL - 95

SP - 250

EP - 256

JO - Radiotherapy and oncology

JF - Radiotherapy and oncology

SN - 0167-8140

IS - 2

ER -

ID: 1034734