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Circular RNAs open a new chapter in cardiovascular biology. / Aufiero, Simona; Reckman, Yolan J.; Pinto, Yigal M.; Creemers, Esther E.

In: Nature reviews. Cardiology, Vol. 16, No. 8, 08.2019, p. 503–514.

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@article{f75631bf919841fbac508cc5b73185fa,
title = "Circular RNAs open a new chapter in cardiovascular biology",
abstract = "Circular RNAs (circRNAs) are emerging as a new class of non-coding RNA molecules. This unusual class of RNA species is generated by a back-splicing event of one or two exons, resulting in a covalently closed circRNA molecule. Owing to their circular form, circRNAs are protected from degradation by exonucleases and have greater stability than linear RNA. Advances in computational analysis of RNA sequencing have revealed that thousands of different circRNAs are expressed in a wide range of mammalian tissues, including the cardiovascular system. Moreover, numerous circRNAs are expressed in a disease-specific manner. A great deal of progress has been made in understanding the biogenesis and function of these circRNAs. In this Review, we discuss the current understanding of circRNA biogenesis and function, with a particular emphasis on the cardiovascular system.",
author = "Simona Aufiero and Reckman, {Yolan J.} and Pinto, {Yigal M.} and Creemers, {Esther E.}",
year = "2019",
month = "8",
doi = "10.1038/s41569-019-0185-2",
language = "English",
volume = "16",
pages = "503–514",
journal = "Nature reviews. Cardiology",
issn = "1759-5002",
publisher = "Nature Publishing Group",
number = "8",

}

RIS

TY - JOUR

T1 - Circular RNAs open a new chapter in cardiovascular biology

AU - Aufiero, Simona

AU - Reckman, Yolan J.

AU - Pinto, Yigal M.

AU - Creemers, Esther E.

PY - 2019/8

Y1 - 2019/8

N2 - Circular RNAs (circRNAs) are emerging as a new class of non-coding RNA molecules. This unusual class of RNA species is generated by a back-splicing event of one or two exons, resulting in a covalently closed circRNA molecule. Owing to their circular form, circRNAs are protected from degradation by exonucleases and have greater stability than linear RNA. Advances in computational analysis of RNA sequencing have revealed that thousands of different circRNAs are expressed in a wide range of mammalian tissues, including the cardiovascular system. Moreover, numerous circRNAs are expressed in a disease-specific manner. A great deal of progress has been made in understanding the biogenesis and function of these circRNAs. In this Review, we discuss the current understanding of circRNA biogenesis and function, with a particular emphasis on the cardiovascular system.

AB - Circular RNAs (circRNAs) are emerging as a new class of non-coding RNA molecules. This unusual class of RNA species is generated by a back-splicing event of one or two exons, resulting in a covalently closed circRNA molecule. Owing to their circular form, circRNAs are protected from degradation by exonucleases and have greater stability than linear RNA. Advances in computational analysis of RNA sequencing have revealed that thousands of different circRNAs are expressed in a wide range of mammalian tissues, including the cardiovascular system. Moreover, numerous circRNAs are expressed in a disease-specific manner. A great deal of progress has been made in understanding the biogenesis and function of these circRNAs. In this Review, we discuss the current understanding of circRNA biogenesis and function, with a particular emphasis on the cardiovascular system.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85063930830&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/30952956

U2 - 10.1038/s41569-019-0185-2

DO - 10.1038/s41569-019-0185-2

M3 - Review article

C2 - 30952956

VL - 16

SP - 503

EP - 514

JO - Nature reviews. Cardiology

JF - Nature reviews. Cardiology

SN - 1759-5002

IS - 8

ER -

ID: 6332458