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Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma

Research output: Contribution to journal › Article › Academic › peer-review

DOI

https://doi.org/10.3389/fonc.2022.929123
Final published version

Kaylee M. Keller
Thomas F. Eleveld
Linda Schild
Kim van den Handel
Marlinde van den Boogaard
Vicky Amo-Addae
Selma Eising
Kimberley Ober
Bianca Koopmans
Leendert Looijenga
Godelieve A. M. Tytgat
Bauke Ylstra
Jan J. Molenaar
M. Emmy M. Dolman
Sander R. van Hooff

Original language	English
Article number	929123
Journal	Frontiers in oncology
Volume	12
DOIs	https://doi.org/10.3389/fonc.2022.929123
Publication status	Published - 27 Sept 2022

Research areas

MYCN amplification, checkpoint kinase 1 (CHK1), chromosome 11q deletion, neuroblastoma, pediatric cancer, prexasertib, replication stress, synergy

ID: 26499964