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Cerebral venous thrombosis in pneumococcal meningitis : An autopsy study. / Deliran, Shahrzad S.; Engelen-Lee, Joo-Yeon; Brouwer, Matthijs C.; van de Beek, Diederik.

In: Clinical neuropathology, Vol. 40, No. 5, 2021, p. 126-133.

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@article{273d521171544bbab9c17622155c1b16,
title = "Cerebral venous thrombosis in pneumococcal meningitis: An autopsy study",
abstract = "Aims: Cerebral venous thrombosis (CVT) is a rare but severe complication of bacterial meningitis. The histopathological features of CVT in meningitis patients have not been described. Materials and methods: We studied histopathology findings of brain autopsy material from 2 patients with bacterial meningitis complicated by CVT and compared findings with those in 3 CVT patients without meningitis and 1 patient with bacterial meningitis without CVT. The histological slides were re-evaluated and assessed for the presence of thrombosis, cerebral venous sinus mural inflammation and bleeding, inflammation at the thrombosis attachment point, endothelial abnormalities, and the presence of bacteria. Results: The 2 patients who died of bacterial meningitis complicated by CVT showed multifocal deep intramural inflammation in the cerebral venous sinus, whereas this was absent in patients with only bacterial meningitis or CVT. Bacteria were identified within the intramural inflammation and thrombus. Conclusion: We observed bacterial invasion causing multifocal deep intramural inflammation and venous wall disintegration as CVT in pneumococcal meningitis.",
keywords = "Autopsy, Bacterial meningitis, Cerebral venous thrombosis, Histopathology",
author = "Deliran, {Shahrzad S.} and Joo-Yeon Engelen-Lee and Brouwer, {Matthijs C.} and {van de Beek}, Diederik",
note = "Funding Information: This study is supported by the Nether lands Organization for Health Research and Development (ZonMw; NWO-Vici-Grant (91819627) to DvdB, NWO-Vidi-Grant (916.13.078) to MCB.) and the European Research Council (European Research Council Starting Grant to DvdB). The Netherlands Reference Laboratory is funded by the National Institute of Public Health and the Environment. Funding Information: This study is supported by the Netherlands Organization for Health Research and Development (ZonMw; NWO-Vici-Grant (91819627) to DvdB, NWO-Vidi-Grant (916.13.078) to MCB.) and the European Research Council (European Research Council Starting Grant to DvdB). The Netherlands Reference Laboratory is funded by the National Institute of Public Health and the Environment. Publisher Copyright: {\textcopyright}2021 Dustri-Verlag Dr. K. Feistle Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
doi = "10.5414/NP301337",
language = "English",
volume = "40",
pages = "126--133",
journal = "Clinical neuropathology",
issn = "0722-5091",
publisher = "Dustri-Verlag Dr. Karl Feistle",
number = "5",

}

RIS

TY - JOUR

T1 - Cerebral venous thrombosis in pneumococcal meningitis

T2 - An autopsy study

AU - Deliran, Shahrzad S.

AU - Engelen-Lee, Joo-Yeon

AU - Brouwer, Matthijs C.

AU - van de Beek, Diederik

N1 - Funding Information: This study is supported by the Nether lands Organization for Health Research and Development (ZonMw; NWO-Vici-Grant (91819627) to DvdB, NWO-Vidi-Grant (916.13.078) to MCB.) and the European Research Council (European Research Council Starting Grant to DvdB). The Netherlands Reference Laboratory is funded by the National Institute of Public Health and the Environment. Funding Information: This study is supported by the Netherlands Organization for Health Research and Development (ZonMw; NWO-Vici-Grant (91819627) to DvdB, NWO-Vidi-Grant (916.13.078) to MCB.) and the European Research Council (European Research Council Starting Grant to DvdB). The Netherlands Reference Laboratory is funded by the National Institute of Public Health and the Environment. Publisher Copyright: ©2021 Dustri-Verlag Dr. K. Feistle Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021

Y1 - 2021

N2 - Aims: Cerebral venous thrombosis (CVT) is a rare but severe complication of bacterial meningitis. The histopathological features of CVT in meningitis patients have not been described. Materials and methods: We studied histopathology findings of brain autopsy material from 2 patients with bacterial meningitis complicated by CVT and compared findings with those in 3 CVT patients without meningitis and 1 patient with bacterial meningitis without CVT. The histological slides were re-evaluated and assessed for the presence of thrombosis, cerebral venous sinus mural inflammation and bleeding, inflammation at the thrombosis attachment point, endothelial abnormalities, and the presence of bacteria. Results: The 2 patients who died of bacterial meningitis complicated by CVT showed multifocal deep intramural inflammation in the cerebral venous sinus, whereas this was absent in patients with only bacterial meningitis or CVT. Bacteria were identified within the intramural inflammation and thrombus. Conclusion: We observed bacterial invasion causing multifocal deep intramural inflammation and venous wall disintegration as CVT in pneumococcal meningitis.

AB - Aims: Cerebral venous thrombosis (CVT) is a rare but severe complication of bacterial meningitis. The histopathological features of CVT in meningitis patients have not been described. Materials and methods: We studied histopathology findings of brain autopsy material from 2 patients with bacterial meningitis complicated by CVT and compared findings with those in 3 CVT patients without meningitis and 1 patient with bacterial meningitis without CVT. The histological slides were re-evaluated and assessed for the presence of thrombosis, cerebral venous sinus mural inflammation and bleeding, inflammation at the thrombosis attachment point, endothelial abnormalities, and the presence of bacteria. Results: The 2 patients who died of bacterial meningitis complicated by CVT showed multifocal deep intramural inflammation in the cerebral venous sinus, whereas this was absent in patients with only bacterial meningitis or CVT. Bacteria were identified within the intramural inflammation and thrombus. Conclusion: We observed bacterial invasion causing multifocal deep intramural inflammation and venous wall disintegration as CVT in pneumococcal meningitis.

KW - Autopsy

KW - Bacterial meningitis

KW - Cerebral venous thrombosis

KW - Histopathology

UR - http://www.scopus.com/inward/record.url?scp=85105761910&partnerID=8YFLogxK

U2 - 10.5414/NP301337

DO - 10.5414/NP301337

M3 - Article

C2 - 33433314

VL - 40

SP - 126

EP - 133

JO - Clinical neuropathology

JF - Clinical neuropathology

SN - 0722-5091

IS - 5

ER -

ID: 17809900