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Blood-brain barrier permeability following conventional photon radiotherapy – A systematic review and meta-analysis of clinical and preclinical studies. / Hart, Elvin't; Odé, Zelda; Derieppe, Marc P. P. et al.

In: Clinical and Translational Radiation Oncology, Vol. 35, 01.07.2022, p. 44-55.

Research output: Contribution to journalReview articleAcademicpeer-review

Harvard

Hart, E, Odé, Z, Derieppe, MPP, Groenink, L, Heymans, MW, Otten, R, Lequin, MH, Janssens, GOR, Hoving, EW & van Vuurden, DG 2022, 'Blood-brain barrier permeability following conventional photon radiotherapy – A systematic review and meta-analysis of clinical and preclinical studies', Clinical and Translational Radiation Oncology, vol. 35, pp. 44-55. https://doi.org/10.1016/j.ctro.2022.04.013

APA

Hart, E., Odé, Z., Derieppe, M. P. P., Groenink, L., Heymans, M. W., Otten, R., Lequin, M. H., Janssens, G. O. R., Hoving, E. W., & van Vuurden, D. G. (2022). Blood-brain barrier permeability following conventional photon radiotherapy – A systematic review and meta-analysis of clinical and preclinical studies. Clinical and Translational Radiation Oncology, 35, 44-55. https://doi.org/10.1016/j.ctro.2022.04.013

Vancouver

Hart E, Odé Z, Derieppe MPP, Groenink L, Heymans MW, Otten R et al. Blood-brain barrier permeability following conventional photon radiotherapy – A systematic review and meta-analysis of clinical and preclinical studies. Clinical and Translational Radiation Oncology. 2022 Jul 1;35:44-55. doi: 10.1016/j.ctro.2022.04.013

Author

Hart, Elvin't ; Odé, Zelda ; Derieppe, Marc P. P. et al. / Blood-brain barrier permeability following conventional photon radiotherapy – A systematic review and meta-analysis of clinical and preclinical studies. In: Clinical and Translational Radiation Oncology. 2022 ; Vol. 35. pp. 44-55.

BibTeX

@article{beb80be75c60441f86fe72fcc5c5402f,
title = "Blood-brain barrier permeability following conventional photon radiotherapy – A systematic review and meta-analysis of clinical and preclinical studies",
abstract = "Radiotherapy (RT) is a cornerstone treatment strategy for brain tumours. Besides cytotoxicity, RT can cause disruption of the blood–brain barrier (BBB), resulting in an increased permeability into the surrounding brain parenchyma. Although this effect is generally acknowledged, it remains unclear how and to what extent different radiation schemes affect BBB integrity. The aim of this systematic review and meta-analysis is to investigate the effect of photon RT regimens on BBB permeability, including its reversibility, in clinical and preclinical studies. We systematically reviewed relevant clinical and preclinical literature in PubMed, Embase, and Cochrane search engines. A total of 69 included studies (20 clinical, 49 preclinical) were qualitatively and quantitatively analysed by meta-analysis and evaluated on key determinants of RT-induced BBB permeability in different disease types and RT protocols. Qualitative data synthesis showed that 35% of the included clinical studies reported BBB disruption following RT, whereas 30% were inconclusive. Interestingly, no compelling differences were observed between studies with different calculated biological effective doses based on the fractionation schemes and cumulative doses; however, increased BBB disruption was noted during patient follow-up after treatment. Qualitative analysis of preclinical studies showed RT BBB disruption in 78% of the included studies, which was significantly confirmed by meta-analysis (p < 0.01). Of note, a high risk of bias, publication bias and a high heterogeneity across the studies was observed. This systematic review and meta-analysis sheds light on the impact of RT protocols on BBB integrity and opens the discussion for integrating this factor in the decision-making process of future RT, with better study of its occurrence and influence on concomitant or adjuvant therapies.",
keywords = "Blood-brain barrier, Dose Fractionation, Permeability, Radiotherapy, Radiotherapy Dosage",
author = "Elvin't Hart and Zelda Od{\'e} and Derieppe, {Marc P. P.} and Lucianne Groenink and Heymans, {Martijn W.} and Ren{\'e} Otten and Lequin, {Maarten H.} and Janssens, {Geert O. R.} and Hoving, {Eelco W.} and {van Vuurden}, {Dannis G.}",
note = "Funding Information: The review has been supported by the KWF Young Investigator Award (KWF 10911, Dr. D.G. van Vuurden. Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
month = jul,
day = "1",
doi = "10.1016/j.ctro.2022.04.013",
language = "English",
volume = "35",
pages = "44--55",
journal = "Clinical and Translational Radiation Oncology",
issn = "2405-6308",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Blood-brain barrier permeability following conventional photon radiotherapy – A systematic review and meta-analysis of clinical and preclinical studies

AU - Hart, Elvin't

AU - Odé, Zelda

AU - Derieppe, Marc P. P.

AU - Groenink, Lucianne

AU - Heymans, Martijn W.

AU - Otten, René

AU - Lequin, Maarten H.

AU - Janssens, Geert O. R.

AU - Hoving, Eelco W.

AU - van Vuurden, Dannis G.

N1 - Funding Information: The review has been supported by the KWF Young Investigator Award (KWF 10911, Dr. D.G. van Vuurden. Publisher Copyright: © 2022 The Authors

PY - 2022/7/1

Y1 - 2022/7/1

N2 - Radiotherapy (RT) is a cornerstone treatment strategy for brain tumours. Besides cytotoxicity, RT can cause disruption of the blood–brain barrier (BBB), resulting in an increased permeability into the surrounding brain parenchyma. Although this effect is generally acknowledged, it remains unclear how and to what extent different radiation schemes affect BBB integrity. The aim of this systematic review and meta-analysis is to investigate the effect of photon RT regimens on BBB permeability, including its reversibility, in clinical and preclinical studies. We systematically reviewed relevant clinical and preclinical literature in PubMed, Embase, and Cochrane search engines. A total of 69 included studies (20 clinical, 49 preclinical) were qualitatively and quantitatively analysed by meta-analysis and evaluated on key determinants of RT-induced BBB permeability in different disease types and RT protocols. Qualitative data synthesis showed that 35% of the included clinical studies reported BBB disruption following RT, whereas 30% were inconclusive. Interestingly, no compelling differences were observed between studies with different calculated biological effective doses based on the fractionation schemes and cumulative doses; however, increased BBB disruption was noted during patient follow-up after treatment. Qualitative analysis of preclinical studies showed RT BBB disruption in 78% of the included studies, which was significantly confirmed by meta-analysis (p < 0.01). Of note, a high risk of bias, publication bias and a high heterogeneity across the studies was observed. This systematic review and meta-analysis sheds light on the impact of RT protocols on BBB integrity and opens the discussion for integrating this factor in the decision-making process of future RT, with better study of its occurrence and influence on concomitant or adjuvant therapies.

AB - Radiotherapy (RT) is a cornerstone treatment strategy for brain tumours. Besides cytotoxicity, RT can cause disruption of the blood–brain barrier (BBB), resulting in an increased permeability into the surrounding brain parenchyma. Although this effect is generally acknowledged, it remains unclear how and to what extent different radiation schemes affect BBB integrity. The aim of this systematic review and meta-analysis is to investigate the effect of photon RT regimens on BBB permeability, including its reversibility, in clinical and preclinical studies. We systematically reviewed relevant clinical and preclinical literature in PubMed, Embase, and Cochrane search engines. A total of 69 included studies (20 clinical, 49 preclinical) were qualitatively and quantitatively analysed by meta-analysis and evaluated on key determinants of RT-induced BBB permeability in different disease types and RT protocols. Qualitative data synthesis showed that 35% of the included clinical studies reported BBB disruption following RT, whereas 30% were inconclusive. Interestingly, no compelling differences were observed between studies with different calculated biological effective doses based on the fractionation schemes and cumulative doses; however, increased BBB disruption was noted during patient follow-up after treatment. Qualitative analysis of preclinical studies showed RT BBB disruption in 78% of the included studies, which was significantly confirmed by meta-analysis (p < 0.01). Of note, a high risk of bias, publication bias and a high heterogeneity across the studies was observed. This systematic review and meta-analysis sheds light on the impact of RT protocols on BBB integrity and opens the discussion for integrating this factor in the decision-making process of future RT, with better study of its occurrence and influence on concomitant or adjuvant therapies.

KW - Blood-brain barrier

KW - Dose Fractionation

KW - Permeability

KW - Radiotherapy

KW - Radiotherapy Dosage

UR - http://www.scopus.com/inward/record.url?scp=85130131338&partnerID=8YFLogxK

U2 - 10.1016/j.ctro.2022.04.013

DO - 10.1016/j.ctro.2022.04.013

M3 - Review article

C2 - 35601799

VL - 35

SP - 44

EP - 55

JO - Clinical and Translational Radiation Oncology

JF - Clinical and Translational Radiation Oncology

SN - 2405-6308

ER -

ID: 25216968