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Biphasic Glucocorticoid Rhythm in One-Month-Old Infants: Reflection of a Developing HPA-Axis? / Hollanders, Jonneke J.; van der Voorn, Bibian; de Goede, Paul et al.

In: Journal of clinical endocrinology and metabolism, Vol. 105, No. 3, dgz089, 08.01.2020.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

Hollanders, JJ, van der Voorn, B, de Goede, P, Toorop, AA, Dijkstra, LR, Honig, A, Rotteveel, J, Dolman, KM, Kalsbeek, A & Finken, MJJ 2020, 'Biphasic Glucocorticoid Rhythm in One-Month-Old Infants: Reflection of a Developing HPA-Axis?', Journal of clinical endocrinology and metabolism, vol. 105, no. 3, dgz089. https://doi.org/10.1210/clinem/dgz089

APA

Hollanders, J. J., van der Voorn, B., de Goede, P., Toorop, A. A., Dijkstra, L. R., Honig, A., Rotteveel, J., Dolman, K. M., Kalsbeek, A., & Finken, M. J. J. (2020). Biphasic Glucocorticoid Rhythm in One-Month-Old Infants: Reflection of a Developing HPA-Axis? Journal of clinical endocrinology and metabolism, 105(3), [dgz089]. https://doi.org/10.1210/clinem/dgz089

Vancouver

Hollanders JJ, van der Voorn B, de Goede P, Toorop AA, Dijkstra LR, Honig A et al. Biphasic Glucocorticoid Rhythm in One-Month-Old Infants: Reflection of a Developing HPA-Axis? Journal of clinical endocrinology and metabolism. 2020 Jan 8;105(3):dgz089. doi: 10.1210/clinem/dgz089

Author

Hollanders, Jonneke J. ; van der Voorn, Bibian ; de Goede, Paul et al. / Biphasic Glucocorticoid Rhythm in One-Month-Old Infants: Reflection of a Developing HPA-Axis?. In: Journal of clinical endocrinology and metabolism. 2020 ; Vol. 105, No. 3.

BibTeX

@article{bf5e216dfcfb49a89f17bd8440d4c487,
title = "Biphasic Glucocorticoid Rhythm in One-Month-Old Infants: Reflection of a Developing HPA-Axis?",
abstract = "CONTEXT: The hypothalamus-pituitary-adrenal (HPA) axis displays a diurnal rhythm. However, little is known about its development in early life. OBJECTIVE: To describe HPA-axis activity and study possible influencing factors in 1-month-old infants. DESIGN: Observational. SETTING: Amsterdam University Medical Center, location VU University Medical Center (VUMC), and Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam. PARTICIPANTS: Fifty-five mother-infant pairs. INTERVENTIONS: Collection of breast milk and infants' saliva 1 month postpartum for analysis of glucocorticoids (GCs; ie, cortisol and cortisone) using liquid chromatography- tandem mass spectrometry. MAIN OUTCOME MEASURE: GC rhythm in infants' saliva and associations with vulnerability for maternal psychological distress (increased Hospital Anxiety and Depression Scale [HADS] score) or consultation at the Psychiatric Obstetric Pediatric (POP clinic), season at sampling, sex, and breast milk GC rhythmicity analyzed with SigmaPlot 14.0 software (Systat Software, San Jose, CA, USA) and regression analyses. RESULTS: A significant biphasic GC rhythm was detected in infants, with mean peaks [standard error of the mean, SEM] at 6:53 am [1:01] and 18:36 pm [1:49] for cortisol, and at 8:50 am [1:11] and 19:57 pm [1:13] for cortisone. HADS score, POP consultation, season at sampling, and sex were not associated with the infants' GC rhythm. Breast milk cortisol maximum was positively associated with infants' cortisol area-under-the-curve (AUC) increase and maximum. Higher breast milk cortisone AUC increase, AUC ground, and maximum were associated with an earlier maximum in infants. Breast milk and infant GC concentrations were associated between 6:00 am and 9:00 am. CONCLUSIONS: A biphasic GC rhythm, peaking in the morning and evening, was seen in 1-month-old infants at a group level. Breast milk GC parameters might be associated with the infants' GC rhythm, possibly caused by a signaling effect of breast milk GCs, or as an associative effect of increased mother-infant synchrony. These results contribute to an increased understanding of early life HPA-axis development.",
author = "Hollanders, {Jonneke J.} and {van der Voorn}, Bibian and {de Goede}, Paul and Toorop, {Alyssa A.} and Dijkstra, {Lisette R.} and Adriaan Honig and Joost Rotteveel and Dolman, {Koert M.} and Andries Kalsbeek and Finken, {Martijn J. J.}",
year = "2020",
month = jan,
day = "8",
doi = "10.1210/clinem/dgz089",
language = "English",
volume = "105",
journal = "Journal of clinical endocrinology and metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "3",

}

RIS

TY - JOUR

T1 - Biphasic Glucocorticoid Rhythm in One-Month-Old Infants: Reflection of a Developing HPA-Axis?

AU - Hollanders, Jonneke J.

AU - van der Voorn, Bibian

AU - de Goede, Paul

AU - Toorop, Alyssa A.

AU - Dijkstra, Lisette R.

AU - Honig, Adriaan

AU - Rotteveel, Joost

AU - Dolman, Koert M.

AU - Kalsbeek, Andries

AU - Finken, Martijn J. J.

PY - 2020/1/8

Y1 - 2020/1/8

N2 - CONTEXT: The hypothalamus-pituitary-adrenal (HPA) axis displays a diurnal rhythm. However, little is known about its development in early life. OBJECTIVE: To describe HPA-axis activity and study possible influencing factors in 1-month-old infants. DESIGN: Observational. SETTING: Amsterdam University Medical Center, location VU University Medical Center (VUMC), and Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam. PARTICIPANTS: Fifty-five mother-infant pairs. INTERVENTIONS: Collection of breast milk and infants' saliva 1 month postpartum for analysis of glucocorticoids (GCs; ie, cortisol and cortisone) using liquid chromatography- tandem mass spectrometry. MAIN OUTCOME MEASURE: GC rhythm in infants' saliva and associations with vulnerability for maternal psychological distress (increased Hospital Anxiety and Depression Scale [HADS] score) or consultation at the Psychiatric Obstetric Pediatric (POP clinic), season at sampling, sex, and breast milk GC rhythmicity analyzed with SigmaPlot 14.0 software (Systat Software, San Jose, CA, USA) and regression analyses. RESULTS: A significant biphasic GC rhythm was detected in infants, with mean peaks [standard error of the mean, SEM] at 6:53 am [1:01] and 18:36 pm [1:49] for cortisol, and at 8:50 am [1:11] and 19:57 pm [1:13] for cortisone. HADS score, POP consultation, season at sampling, and sex were not associated with the infants' GC rhythm. Breast milk cortisol maximum was positively associated with infants' cortisol area-under-the-curve (AUC) increase and maximum. Higher breast milk cortisone AUC increase, AUC ground, and maximum were associated with an earlier maximum in infants. Breast milk and infant GC concentrations were associated between 6:00 am and 9:00 am. CONCLUSIONS: A biphasic GC rhythm, peaking in the morning and evening, was seen in 1-month-old infants at a group level. Breast milk GC parameters might be associated with the infants' GC rhythm, possibly caused by a signaling effect of breast milk GCs, or as an associative effect of increased mother-infant synchrony. These results contribute to an increased understanding of early life HPA-axis development.

AB - CONTEXT: The hypothalamus-pituitary-adrenal (HPA) axis displays a diurnal rhythm. However, little is known about its development in early life. OBJECTIVE: To describe HPA-axis activity and study possible influencing factors in 1-month-old infants. DESIGN: Observational. SETTING: Amsterdam University Medical Center, location VU University Medical Center (VUMC), and Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam. PARTICIPANTS: Fifty-five mother-infant pairs. INTERVENTIONS: Collection of breast milk and infants' saliva 1 month postpartum for analysis of glucocorticoids (GCs; ie, cortisol and cortisone) using liquid chromatography- tandem mass spectrometry. MAIN OUTCOME MEASURE: GC rhythm in infants' saliva and associations with vulnerability for maternal psychological distress (increased Hospital Anxiety and Depression Scale [HADS] score) or consultation at the Psychiatric Obstetric Pediatric (POP clinic), season at sampling, sex, and breast milk GC rhythmicity analyzed with SigmaPlot 14.0 software (Systat Software, San Jose, CA, USA) and regression analyses. RESULTS: A significant biphasic GC rhythm was detected in infants, with mean peaks [standard error of the mean, SEM] at 6:53 am [1:01] and 18:36 pm [1:49] for cortisol, and at 8:50 am [1:11] and 19:57 pm [1:13] for cortisone. HADS score, POP consultation, season at sampling, and sex were not associated with the infants' GC rhythm. Breast milk cortisol maximum was positively associated with infants' cortisol area-under-the-curve (AUC) increase and maximum. Higher breast milk cortisone AUC increase, AUC ground, and maximum were associated with an earlier maximum in infants. Breast milk and infant GC concentrations were associated between 6:00 am and 9:00 am. CONCLUSIONS: A biphasic GC rhythm, peaking in the morning and evening, was seen in 1-month-old infants at a group level. Breast milk GC parameters might be associated with the infants' GC rhythm, possibly caused by a signaling effect of breast milk GCs, or as an associative effect of increased mother-infant synchrony. These results contribute to an increased understanding of early life HPA-axis development.

UR - http://www.scopus.com/inward/record.url?scp=85079562439&partnerID=8YFLogxK

U2 - 10.1210/clinem/dgz089

DO - 10.1210/clinem/dgz089

M3 - Article

C2 - 31650172

VL - 105

JO - Journal of clinical endocrinology and metabolism

JF - Journal of clinical endocrinology and metabolism

SN - 0021-972X

IS - 3

M1 - dgz089

ER -

ID: 10968410