Bacterial persister-cells and spores in the food chain: Their potential inactivation by antimicrobial peptides (amps)

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Bacterial persister-cells and spores in the food chain: Their potential inactivation by antimicrobial peptides (amps). / Liu, Shiqi; Brul, Stanley; Zaat, Sebastian A. J.

In: International journal of molecular sciences, Vol. 21, No. 23, 8967, 01.12.2020, p. 1-24.

Research output: Contribution to journal › Review article › Academic › peer-review

BibTeX

@article{309f3a46fa754a3fbb6ebb321bfe8c04,

title = "Bacterial persister-cells and spores in the food chain: Their potential inactivation by antimicrobial peptides (amps)",

abstract = "The occurrence of bacterial pathogens in the food chain has caused a severe impact on public health and welfare in both developing and developed countries. Moreover, the existence of antimicrobial-tolerant persisting morphotypes of these pathogens including both persister-cells as well as bacterial spores contributes to difficulty in elimination and in recurrent infection. Therefore, comprehensive understanding of the behavior of these persisting bacterial forms in their environmental niche and upon infection of humans is necessary. Since traditional antimicrobials fail to kill persisters and spores due to their (extremely) low metabolic activities, antimicrobial peptides (AMPs) have been intensively investigated as one of the most promising strategies against these persisting bacterial forms, showing high efficacy of inactivation. In addition, AMP-based foodborne pathogen detection and prevention of infection has made significant progress. This review focuses on recent research on common bacterial pathogens in the food chain, their persisting morphotypes, and on AMP-based solutions. Challenges in research and application of AMPs are described.",

keywords = "Antimicrobial peptides, Bacterial spores, Foodborne pathogen, Persisters",

author = "Shiqi Liu and Stanley Brul and Zaat, {Sebastian A. J.}",

year = "2020",

month = dec,

day = "1",

doi = "10.3390/ijms21238967",

language = "English",

volume = "21",

pages = "1--24",

journal = "International journal of molecular sciences",

issn = "1661-6596",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "23",

}

RIS

TY - JOUR

T1 - Bacterial persister-cells and spores in the food chain: Their potential inactivation by antimicrobial peptides (amps)

AU - Liu, Shiqi

AU - Brul, Stanley

AU - Zaat, Sebastian A. J.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - The occurrence of bacterial pathogens in the food chain has caused a severe impact on public health and welfare in both developing and developed countries. Moreover, the existence of antimicrobial-tolerant persisting morphotypes of these pathogens including both persister-cells as well as bacterial spores contributes to difficulty in elimination and in recurrent infection. Therefore, comprehensive understanding of the behavior of these persisting bacterial forms in their environmental niche and upon infection of humans is necessary. Since traditional antimicrobials fail to kill persisters and spores due to their (extremely) low metabolic activities, antimicrobial peptides (AMPs) have been intensively investigated as one of the most promising strategies against these persisting bacterial forms, showing high efficacy of inactivation. In addition, AMP-based foodborne pathogen detection and prevention of infection has made significant progress. This review focuses on recent research on common bacterial pathogens in the food chain, their persisting morphotypes, and on AMP-based solutions. Challenges in research and application of AMPs are described.

AB - The occurrence of bacterial pathogens in the food chain has caused a severe impact on public health and welfare in both developing and developed countries. Moreover, the existence of antimicrobial-tolerant persisting morphotypes of these pathogens including both persister-cells as well as bacterial spores contributes to difficulty in elimination and in recurrent infection. Therefore, comprehensive understanding of the behavior of these persisting bacterial forms in their environmental niche and upon infection of humans is necessary. Since traditional antimicrobials fail to kill persisters and spores due to their (extremely) low metabolic activities, antimicrobial peptides (AMPs) have been intensively investigated as one of the most promising strategies against these persisting bacterial forms, showing high efficacy of inactivation. In addition, AMP-based foodborne pathogen detection and prevention of infection has made significant progress. This review focuses on recent research on common bacterial pathogens in the food chain, their persisting morphotypes, and on AMP-based solutions. Challenges in research and application of AMPs are described.

KW - Antimicrobial peptides

KW - Bacterial spores

KW - Foodborne pathogen

KW - Persisters

UR - http://www.scopus.com/inward/record.url?scp=85096702034&partnerID=8YFLogxK

U2 - 10.3390/ijms21238967

DO - 10.3390/ijms21238967

M3 - Review article

C2 - 33260797

VL - 21

SP - 1

EP - 24

JO - International journal of molecular sciences

JF - International journal of molecular sciences

SN - 1661-6596

IS - 23

M1 - 8967

ER -

ID: 14405287

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