Standard

Awakening after a sleeping pill : Restoring functional brain networks after severe brain injury. / Arnts, Hisse; van Erp, Willemijn S.; Boon, Lennard I. et al.

In: Cortex; a journal devoted to the study of the nervous system and behavior, Vol. 132, 01.11.2020, p. 135-146.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

Arnts, H, van Erp, WS, Boon, LI, Bosman, CA, Admiraal, MM, Schrantee, A, Pennartz, CMA, Schuurman, R, Stam, CJ, van Rootselaar, A-F, Hillebrand, A & van den Munckhof, P 2020, 'Awakening after a sleeping pill: Restoring functional brain networks after severe brain injury', Cortex; a journal devoted to the study of the nervous system and behavior, vol. 132, pp. 135-146. https://doi.org/10.1016/j.cortex.2020.08.011

APA

Arnts, H., van Erp, W. S., Boon, L. I., Bosman, C. A., Admiraal, M. M., Schrantee, A., Pennartz, C. M. A., Schuurman, R., Stam, C. J., van Rootselaar, A-F., Hillebrand, A., & van den Munckhof, P. (2020). Awakening after a sleeping pill: Restoring functional brain networks after severe brain injury. Cortex; a journal devoted to the study of the nervous system and behavior, 132, 135-146. https://doi.org/10.1016/j.cortex.2020.08.011

Vancouver

Arnts H, van Erp WS, Boon LI, Bosman CA, Admiraal MM, Schrantee A et al. Awakening after a sleeping pill: Restoring functional brain networks after severe brain injury. Cortex; a journal devoted to the study of the nervous system and behavior. 2020 Nov 1;132:135-146. doi: 10.1016/j.cortex.2020.08.011

Author

Arnts, Hisse ; van Erp, Willemijn S. ; Boon, Lennard I. et al. / Awakening after a sleeping pill : Restoring functional brain networks after severe brain injury. In: Cortex; a journal devoted to the study of the nervous system and behavior. 2020 ; Vol. 132. pp. 135-146.

BibTeX

@article{47fe449b9d9e4d4cb415e71512085bbb,
title = "Awakening after a sleeping pill: Restoring functional brain networks after severe brain injury",
abstract = "Some patients with severe brain injury show short-term neurological improvements, such as recovery of consciousness, motor function, or speech after administering zolpidem, a GABA receptor agonist. The working mechanism of this paradoxical phenomenon remains unknown. In this study, we used electroencephalography and magnetoencephalography to investigate a spectacular zolpidem-induced awakening, including the recovery of functional communication and the ability to walk in a patient with severe hypoxic-ischemic brain injury. We show that cognitive deficits, speech loss, and motor impairments after severe brain injury are associated with stronger beta band connectivity throughout the brain and suggest that neurological recovery after zolpidem occurs with the restoration of beta band connectivity. This exploratory work proposes an essential role for beta rhythms in goal-directed behavior and cognition. It advocates further fundamental and clinical research on the role of increased beta band connectivity in the development of neurological deficits after severe brain injury.",
keywords = "Awakening, Beta band, Electroencephalography, Functional connectivity, Magnetoencephalography, Oscillations, Severe brain injury, Zolpidem",
author = "Hisse Arnts and {van Erp}, {Willemijn S.} and Boon, {Lennard I.} and Bosman, {Conrado A.} and Admiraal, {Marjolein M.} and Anouk Schrantee and Pennartz, {Cyriel M. A.} and Rick Schuurman and Stam, {Cornelis J.} and {van Rootselaar}, Anne-Fleur and Arjan Hillebrand and {van den Munckhof}, Pepijn",
year = "2020",
month = nov,
day = "1",
doi = "10.1016/j.cortex.2020.08.011",
language = "English",
volume = "132",
pages = "135--146",
journal = "Cortex; a journal devoted to the study of the nervous system and behavior",
issn = "0010-9452",
publisher = "Masson SpA",

}

RIS

TY - JOUR

T1 - Awakening after a sleeping pill

T2 - Restoring functional brain networks after severe brain injury

AU - Arnts, Hisse

AU - van Erp, Willemijn S.

AU - Boon, Lennard I.

AU - Bosman, Conrado A.

AU - Admiraal, Marjolein M.

AU - Schrantee, Anouk

AU - Pennartz, Cyriel M. A.

AU - Schuurman, Rick

AU - Stam, Cornelis J.

AU - van Rootselaar, Anne-Fleur

AU - Hillebrand, Arjan

AU - van den Munckhof, Pepijn

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Some patients with severe brain injury show short-term neurological improvements, such as recovery of consciousness, motor function, or speech after administering zolpidem, a GABA receptor agonist. The working mechanism of this paradoxical phenomenon remains unknown. In this study, we used electroencephalography and magnetoencephalography to investigate a spectacular zolpidem-induced awakening, including the recovery of functional communication and the ability to walk in a patient with severe hypoxic-ischemic brain injury. We show that cognitive deficits, speech loss, and motor impairments after severe brain injury are associated with stronger beta band connectivity throughout the brain and suggest that neurological recovery after zolpidem occurs with the restoration of beta band connectivity. This exploratory work proposes an essential role for beta rhythms in goal-directed behavior and cognition. It advocates further fundamental and clinical research on the role of increased beta band connectivity in the development of neurological deficits after severe brain injury.

AB - Some patients with severe brain injury show short-term neurological improvements, such as recovery of consciousness, motor function, or speech after administering zolpidem, a GABA receptor agonist. The working mechanism of this paradoxical phenomenon remains unknown. In this study, we used electroencephalography and magnetoencephalography to investigate a spectacular zolpidem-induced awakening, including the recovery of functional communication and the ability to walk in a patient with severe hypoxic-ischemic brain injury. We show that cognitive deficits, speech loss, and motor impairments after severe brain injury are associated with stronger beta band connectivity throughout the brain and suggest that neurological recovery after zolpidem occurs with the restoration of beta band connectivity. This exploratory work proposes an essential role for beta rhythms in goal-directed behavior and cognition. It advocates further fundamental and clinical research on the role of increased beta band connectivity in the development of neurological deficits after severe brain injury.

KW - Awakening

KW - Beta band

KW - Electroencephalography

KW - Functional connectivity

KW - Magnetoencephalography

KW - Oscillations

KW - Severe brain injury

KW - Zolpidem

UR - http://www.scopus.com/inward/record.url?scp=85091393855&partnerID=8YFLogxK

U2 - 10.1016/j.cortex.2020.08.011

DO - 10.1016/j.cortex.2020.08.011

M3 - Article

C2 - 32979847

VL - 132

SP - 135

EP - 146

JO - Cortex; a journal devoted to the study of the nervous system and behavior

JF - Cortex; a journal devoted to the study of the nervous system and behavior

SN - 0010-9452

ER -

ID: 13459064