Research output: Contribution to journal › Review article › Academic › peer-review
Are neuromodulation interventions associated with changes in the gut microbiota? A systematic review. / Korenblik, Vera; Brouwer, Marlies E.; Korosi, Aniko et al.
In: Neuropharmacology, Vol. 223, 109318, 01.02.2023.Research output: Contribution to journal › Review article › Academic › peer-review
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TY - JOUR
T1 - Are neuromodulation interventions associated with changes in the gut microbiota? A systematic review
AU - Korenblik, Vera
AU - Brouwer, Marlies E.
AU - Korosi, Aniko
AU - Denys, Damiaan
AU - Bockting, Claudi L. H.
AU - Brul, Stanley
AU - Lok, Anja
N1 - Funding Information: AL and MEB formulated the research question and co-designed the study. VK co-conducted study selection and extraction, supported by MEB and AL. VK co-conducted risk of bias assessment, supported by MEB and AK. VK wrote the manuscript with input from all authors, who all critically reviewed the article prior to submission. Funding Information: Research within the Centre for Urban Mental Health is funded by the University of Amsterdam . Publisher Copyright: © 2022 The Authors
PY - 2023/2/1
Y1 - 2023/2/1
N2 - The microbiota-gut-brain axis (MGBA) refers to the bidirectional communication between the brain and the gut microbiota and recent studies have linked the MGBA to health and disease. Research has so far investigated this axis mainly from microbiota to brain but less is known about the other direction. One approach to examine the MGBA from brain to microbiota is through understanding if and how neuromodulation might impact microbiota. Neuromodulation encompasses a wide range of stimulation techniques and is used to treat neurological, psychiatric and metabolic disorders, like Parkinson's Disease, depression and obesity. Here, we performed a systematic review to investigate whether neuromodulation is associated with subsequent changes in the gut microbiota. Searches in PsycINFO and MEDLINE were performed up to March 2022. Included studies needed to be clinical or preclinical studies comparing the effects of deep brain stimulation, electroconvulsive therapy, repetitive transcranial magnetic stimulation, transcranial direct current stimulation or vagal nerve stimulation on the gut microbiota before and after treatment or between active and control groups. Seven studies were identified. Neuromodulation was associated with changes in relative bacterial abundances, but not with (changes in) α-diversity or β-diversity. Summarizing, currently reported findings suggest that neuromodulation interventions are associated with moderate changes in the gut microbiome. However, findings remain inconclusive due to the limited number and varying quality of included studies, as well as the large heterogeneity between studies. More research is required to more conclusively establish whether, and if so, via which mechanism(s) of action neuromodulation interventions might influence the gut microbiota.
AB - The microbiota-gut-brain axis (MGBA) refers to the bidirectional communication between the brain and the gut microbiota and recent studies have linked the MGBA to health and disease. Research has so far investigated this axis mainly from microbiota to brain but less is known about the other direction. One approach to examine the MGBA from brain to microbiota is through understanding if and how neuromodulation might impact microbiota. Neuromodulation encompasses a wide range of stimulation techniques and is used to treat neurological, psychiatric and metabolic disorders, like Parkinson's Disease, depression and obesity. Here, we performed a systematic review to investigate whether neuromodulation is associated with subsequent changes in the gut microbiota. Searches in PsycINFO and MEDLINE were performed up to March 2022. Included studies needed to be clinical or preclinical studies comparing the effects of deep brain stimulation, electroconvulsive therapy, repetitive transcranial magnetic stimulation, transcranial direct current stimulation or vagal nerve stimulation on the gut microbiota before and after treatment or between active and control groups. Seven studies were identified. Neuromodulation was associated with changes in relative bacterial abundances, but not with (changes in) α-diversity or β-diversity. Summarizing, currently reported findings suggest that neuromodulation interventions are associated with moderate changes in the gut microbiome. However, findings remain inconclusive due to the limited number and varying quality of included studies, as well as the large heterogeneity between studies. More research is required to more conclusively establish whether, and if so, via which mechanism(s) of action neuromodulation interventions might influence the gut microbiota.
KW - Deep brain stimulation
KW - Gut microbiota
KW - Microbiota-gut-brain axis
KW - Neuromodulation
KW - Repetitive transcranial magnetic stimulation
KW - Vagal nerve stimulation
UR - http://www.scopus.com/inward/record.url?scp=85141942989&partnerID=8YFLogxK
U2 - 10.1016/j.neuropharm.2022.109318
DO - 10.1016/j.neuropharm.2022.109318
M3 - Review article
C2 - 36334762
VL - 223
JO - Neuropharmacology
JF - Neuropharmacology
SN - 0028-3908
M1 - 109318
ER -
ID: 27502941