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Aortic valve-mediated wall shear stress is heterogeneous and predicts regional aortic elastic fiber thinning in bicuspid aortic valve-associated aortopathy. / Bollache, Emilie; Guzzardi, David G.; Sattari, Samaneh et al.

In: Journal of thoracic and cardiovascular surgery, Vol. 156, No. 6, 2018, p. 2112-2120.

Research output: Contribution to journal › Article › Academic › peer-review

Harvard

Bollache, E, Guzzardi, DG, Sattari, S, Olsen, KE, di Martino, ES, Malaisrie, SC, van Ooij, P, Collins, J, Carr, J, McCarthy, PM, Markl, M, Barker, AJ & Fedak, PWM 2018, 'Aortic valve-mediated wall shear stress is heterogeneous and predicts regional aortic elastic fiber thinning in bicuspid aortic valve-associated aortopathy', Journal of thoracic and cardiovascular surgery, vol. 156, no. 6, pp. 2112-2120. https://doi.org/10.1016/j.jtcvs.2018.05.095

APA

Bollache, E., Guzzardi, D. G., Sattari, S., Olsen, K. E., di Martino, E. S., Malaisrie, S. C., van Ooij, P., Collins, J., Carr, J., McCarthy, P. M., Markl, M., Barker, A. J., & Fedak, P. W. M. (2018). Aortic valve-mediated wall shear stress is heterogeneous and predicts regional aortic elastic fiber thinning in bicuspid aortic valve-associated aortopathy. Journal of thoracic and cardiovascular surgery, 156(6), 2112-2120. https://doi.org/10.1016/j.jtcvs.2018.05.095

Vancouver

Bollache E, Guzzardi DG, Sattari S, Olsen KE, di Martino ES, Malaisrie SC et al. Aortic valve-mediated wall shear stress is heterogeneous and predicts regional aortic elastic fiber thinning in bicuspid aortic valve-associated aortopathy. Journal of thoracic and cardiovascular surgery. 2018;156(6):2112-2120. doi: 10.1016/j.jtcvs.2018.05.095

Author

Bollache, Emilie ; Guzzardi, David G. ; Sattari, Samaneh et al. / Aortic valve-mediated wall shear stress is heterogeneous and predicts regional aortic elastic fiber thinning in bicuspid aortic valve-associated aortopathy. In: Journal of thoracic and cardiovascular surgery. 2018 ; Vol. 156, No. 6. pp. 2112-2120.

BibTeX

@article{b66877ab430142f384528a4d25868810,
title = "Aortic valve-mediated wall shear stress is heterogeneous and predicts regional aortic elastic fiber thinning in bicuspid aortic valve-associated aortopathy",
abstract = "Objectives: The objectives of this study were to investigate an association between the magnitude of flow-mediated aortic wall shear stress (WSS) and medial wall histopathology in patients with bicuspid aortic valve (BAV) with aortopathy. Methods: Patients with BAV (n = 27; 52 ± 15 years; 3 women; proximal thoracic aorta diameter = 4.4 ± 0.7 and 4.6 ± 0.5 cm) who underwent prophylactic aortic resection received preoperative 3-dimensional time-resolved phase-contrast magnetic resonance imaging with 3-dimensional velocity encoding to quantify WSS relative to a population of healthy age- and sex-matched tricuspid aortic valve control participants (n = 20). Quantitative histopathology was conducted on BAV aorta tissue samples resected at surgery (n = 93), and correlation was performed between elastic fiber thickness and in vivo aortic WSS as continuous variables. Validation of elastic fiber thickness was achieved by correlation relative to tissue stiffness determined using biaxial biomechanical testing (n = 22 samples). Results: Elastic fibers were thinner and WSS was higher along the greater curvature compared with other circumferential regions (vs anterior wall: P =.003 and P =.0001, respectively; lesser curvature: both P =.001). Increased regional WSS was associated with decreased elastic fiber thickness (r = −0.25; P =.02). Patient stratification with subanalysis showed an increase in the correlation between WSS and histopathology with aortic valve stenosis (r = −0.36; P =.002) and smaller aortic diameters (<4.5 cm: r = −0.39; P =.03). Elastic fiber thinning was associated with circumferential stiffness (r = −0.41; P =.06). Conclusions: For patients with BAV, increased aortic valve-mediated WSS is significantly associated with elastic fiber thinning, particularly with aortic valve stenosis and in earlier stages of aortopathy. Elastic fiber thinning correlates with impaired tissue biomechanics. These novel findings further implicate valve-mediated hemodynamics in the progression of BAV aortopathy.",
author = "Emilie Bollache and Guzzardi, {David G.} and Samaneh Sattari and Olsen, {Katherine E.} and {di Martino}, {Elena S.} and Malaisrie, {S. Chris} and {van Ooij}, Pim and Jeremy Collins and James Carr and McCarthy, {Patrick M.} and Michael Markl and Barker, {Alex J.} and Fedak, {Paul W. M.}",
year = "2018",
doi = "10.1016/j.jtcvs.2018.05.095",
language = "English",
volume = "156",
pages = "2112--2120",
journal = "Journal of thoracic and cardiovascular surgery",
issn = "0022-5223",
publisher = "Mosby Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Aortic valve-mediated wall shear stress is heterogeneous and predicts regional aortic elastic fiber thinning in bicuspid aortic valve-associated aortopathy

AU - Bollache, Emilie

AU - Guzzardi, David G.

AU - Sattari, Samaneh

AU - Olsen, Katherine E.

AU - di Martino, Elena S.

AU - Malaisrie, S. Chris

AU - van Ooij, Pim

AU - Collins, Jeremy

AU - Carr, James

AU - McCarthy, Patrick M.

AU - Markl, Michael

AU - Barker, Alex J.

AU - Fedak, Paul W. M.

PY - 2018

Y1 - 2018

N2 - Objectives: The objectives of this study were to investigate an association between the magnitude of flow-mediated aortic wall shear stress (WSS) and medial wall histopathology in patients with bicuspid aortic valve (BAV) with aortopathy. Methods: Patients with BAV (n = 27; 52 ± 15 years; 3 women; proximal thoracic aorta diameter = 4.4 ± 0.7 and 4.6 ± 0.5 cm) who underwent prophylactic aortic resection received preoperative 3-dimensional time-resolved phase-contrast magnetic resonance imaging with 3-dimensional velocity encoding to quantify WSS relative to a population of healthy age- and sex-matched tricuspid aortic valve control participants (n = 20). Quantitative histopathology was conducted on BAV aorta tissue samples resected at surgery (n = 93), and correlation was performed between elastic fiber thickness and in vivo aortic WSS as continuous variables. Validation of elastic fiber thickness was achieved by correlation relative to tissue stiffness determined using biaxial biomechanical testing (n = 22 samples). Results: Elastic fibers were thinner and WSS was higher along the greater curvature compared with other circumferential regions (vs anterior wall: P =.003 and P =.0001, respectively; lesser curvature: both P =.001). Increased regional WSS was associated with decreased elastic fiber thickness (r = −0.25; P =.02). Patient stratification with subanalysis showed an increase in the correlation between WSS and histopathology with aortic valve stenosis (r = −0.36; P =.002) and smaller aortic diameters (<4.5 cm: r = −0.39; P =.03). Elastic fiber thinning was associated with circumferential stiffness (r = −0.41; P =.06). Conclusions: For patients with BAV, increased aortic valve-mediated WSS is significantly associated with elastic fiber thinning, particularly with aortic valve stenosis and in earlier stages of aortopathy. Elastic fiber thinning correlates with impaired tissue biomechanics. These novel findings further implicate valve-mediated hemodynamics in the progression of BAV aortopathy.

AB - Objectives: The objectives of this study were to investigate an association between the magnitude of flow-mediated aortic wall shear stress (WSS) and medial wall histopathology in patients with bicuspid aortic valve (BAV) with aortopathy. Methods: Patients with BAV (n = 27; 52 ± 15 years; 3 women; proximal thoracic aorta diameter = 4.4 ± 0.7 and 4.6 ± 0.5 cm) who underwent prophylactic aortic resection received preoperative 3-dimensional time-resolved phase-contrast magnetic resonance imaging with 3-dimensional velocity encoding to quantify WSS relative to a population of healthy age- and sex-matched tricuspid aortic valve control participants (n = 20). Quantitative histopathology was conducted on BAV aorta tissue samples resected at surgery (n = 93), and correlation was performed between elastic fiber thickness and in vivo aortic WSS as continuous variables. Validation of elastic fiber thickness was achieved by correlation relative to tissue stiffness determined using biaxial biomechanical testing (n = 22 samples). Results: Elastic fibers were thinner and WSS was higher along the greater curvature compared with other circumferential regions (vs anterior wall: P =.003 and P =.0001, respectively; lesser curvature: both P =.001). Increased regional WSS was associated with decreased elastic fiber thickness (r = −0.25; P =.02). Patient stratification with subanalysis showed an increase in the correlation between WSS and histopathology with aortic valve stenosis (r = −0.36; P =.002) and smaller aortic diameters (<4.5 cm: r = −0.39; P =.03). Elastic fiber thinning was associated with circumferential stiffness (r = −0.41; P =.06). Conclusions: For patients with BAV, increased aortic valve-mediated WSS is significantly associated with elastic fiber thinning, particularly with aortic valve stenosis and in earlier stages of aortopathy. Elastic fiber thinning correlates with impaired tissue biomechanics. These novel findings further implicate valve-mediated hemodynamics in the progression of BAV aortopathy.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85050469803&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/30060930

U2 - 10.1016/j.jtcvs.2018.05.095

DO - 10.1016/j.jtcvs.2018.05.095

M3 - Article

C2 - 30060930

VL - 156

SP - 2112

EP - 2120

JO - Journal of thoracic and cardiovascular surgery

JF - Journal of thoracic and cardiovascular surgery

SN - 0022-5223

IS - 6

ER -

ID: 5547130