Research output: Contribution to journal › Article › Academic › peer-review
Antibiotic susceptibility of staphylococcus aureus and streptococcus pneumoniae isolates from the nasopharynx of febrile children under 5 years in Nanoro, Burkina Faso. / Bonko, Massa Dit Achille; Lompo, Palpouguini; Tahita, Marc Christian et al.
In: Antibiotics (Basel, Switzerland), Vol. 10, No. 4, 444, 2021.Research output: Contribution to journal › Article › Academic › peer-review
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TY - JOUR
T1 - Antibiotic susceptibility of staphylococcus aureus and streptococcus pneumoniae isolates from the nasopharynx of febrile children under 5 years in Nanoro, Burkina Faso
AU - Bonko, Massa Dit Achille
AU - Lompo, Palpouguini
AU - Tahita, Marc Christian
AU - Kiemde, Francois
AU - Karama, Ibrahima
AU - Somé, Athanase M.
AU - Mens, Petra F.
AU - Menting, Sandra
AU - Tinto, Halidou
AU - Schallig, Henk D. F. H.
N1 - Funding Information: Funding: A grant from the Netherlands Organization for Health Research and Development (ZonMw), project 205300005; RAPDIF: a rapid diagnostic test for the undifferentiated Fevers and a Discovery Award granted to the research team by the NESTA Foundation (London, UK) supported this research. Funding Information: Standard bacteriological procedures were followed in accordance with the local microbiology standard operating procedures (SOPs) to ensure the reliability of the laboratory results. In addition, all the laboratory processes (culture media, reagents, AST disks and equipment) were quality controlled using American Type Culture Collection (ATCC®) standard reference strains. Furthermore, CRUN microbiology laboratory is enrolled to the external quality assessment program of the National Institute for Communicable Diseases (NICD, Johannesburg, South Africa), supported by the World Health Organization (WHO) Africa. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021
Y1 - 2021
N2 - (1) Background: nasopharynx colonization by resistant Staphylococcus aureus and Streptococcus pneumoniae can lead to serious diseases. Emerging resistance to antibiotics commonly used to treat infections due to these pathogens poses a serious threat to the health system. The present study aimed to determine the antibiotic susceptibility of S. aureus and S. pneumoniae isolates from the febrile children’s nasopharynx under 5 years in Nanoro (Burkina Faso). (2) Methods: bacterial isolates were identified from nasopharyngeal swabs prospectively collected from 629 febrile children. Antibiotic susceptibility of S. aureus and S. pneumoniae isolates was assessed by Kirby–Bauer method and results were interpreted according to the Clinical and Laboratory Standard Institute guidelines. (3) Results: bacterial colonization was confirmed in 154 (24.5%) of children of whom 96.1% carried S. aureus, 3.2% had S. pneumoniae, and 0.6% carried both bacteria. S. aureus isolates showed alarming resistance to penicillin (96.0%) and S. pneumoniae was highly resistant to tetracycline (100%) and trimethoprim–sulfamethoxazole (83.3%), and moderately resistant to penicillin (50.0%). Furthermore, 4.0% of S. aureus identified were methicillin resistant. (4) Conclusion: this study showed concerning resistance rates to antibiotics to treat suspected bacterial respiratory tract infections. The work highlights the necessity to implement continuous antibiotic resistance surveillance.
AB - (1) Background: nasopharynx colonization by resistant Staphylococcus aureus and Streptococcus pneumoniae can lead to serious diseases. Emerging resistance to antibiotics commonly used to treat infections due to these pathogens poses a serious threat to the health system. The present study aimed to determine the antibiotic susceptibility of S. aureus and S. pneumoniae isolates from the febrile children’s nasopharynx under 5 years in Nanoro (Burkina Faso). (2) Methods: bacterial isolates were identified from nasopharyngeal swabs prospectively collected from 629 febrile children. Antibiotic susceptibility of S. aureus and S. pneumoniae isolates was assessed by Kirby–Bauer method and results were interpreted according to the Clinical and Laboratory Standard Institute guidelines. (3) Results: bacterial colonization was confirmed in 154 (24.5%) of children of whom 96.1% carried S. aureus, 3.2% had S. pneumoniae, and 0.6% carried both bacteria. S. aureus isolates showed alarming resistance to penicillin (96.0%) and S. pneumoniae was highly resistant to tetracycline (100%) and trimethoprim–sulfamethoxazole (83.3%), and moderately resistant to penicillin (50.0%). Furthermore, 4.0% of S. aureus identified were methicillin resistant. (4) Conclusion: this study showed concerning resistance rates to antibiotics to treat suspected bacterial respiratory tract infections. The work highlights the necessity to implement continuous antibiotic resistance surveillance.
KW - Antibiotics
KW - Children
KW - Nasopharynx
KW - Resistance
KW - Staphylococcus aureus
KW - Streptococcus pneumoniae
UR - http://www.scopus.com/inward/record.url?scp=85104954512&partnerID=8YFLogxK
U2 - 10.3390/antibiotics10040444
DO - 10.3390/antibiotics10040444
M3 - Article
C2 - 33920987
VL - 10
JO - Antibiotics (Basel, Switzerland)
JF - Antibiotics (Basel, Switzerland)
SN - 2079-6382
IS - 4
M1 - 444
ER -
ID: 18091955