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Altered mitochondrial metabolism in the insulin-resistant heart. / Makrecka-Kuka, Marina; Liepinsh, Edgars; Murray, Andrew J. et al.

In: Acta physiologica (Oxford, England), Vol. 228, No. 3, e13430, 01.03.2020.

Research output: Contribution to journalReview articleAcademicpeer-review

Harvard

Makrecka-Kuka, M, Liepinsh, E, Murray, AJ, Lemieux, HL, Dambrova, M, Tepp, K, Puurand, M, Käämbre, T, Han, WH, de Goede, P, O'Brien, KA, Turan, B, Tuncay, E, Olgar, Y, Rolo, AP, Palmeira, CM, Boardman, NT, Wüst, RCI & Larsen, TS 2020, 'Altered mitochondrial metabolism in the insulin-resistant heart', Acta physiologica (Oxford, England), vol. 228, no. 3, e13430. https://doi.org/10.1111/apha.13430

APA

Makrecka-Kuka, M., Liepinsh, E., Murray, A. J., Lemieux, H. L., Dambrova, M., Tepp, K., Puurand, M., Käämbre, T., Han, W. H., de Goede, P., O'Brien, K. A., Turan, B., Tuncay, E., Olgar, Y., Rolo, A. P., Palmeira, C. M., Boardman, N. T., Wüst, R. C. I., & Larsen, T. S. (2020). Altered mitochondrial metabolism in the insulin-resistant heart. Acta physiologica (Oxford, England), 228(3), [e13430]. https://doi.org/10.1111/apha.13430

Vancouver

Makrecka-Kuka M, Liepinsh E, Murray AJ, Lemieux HL, Dambrova M, Tepp K et al. Altered mitochondrial metabolism in the insulin-resistant heart. Acta physiologica (Oxford, England). 2020 Mar 1;228(3):e13430. doi: 10.1111/apha.13430

Author

Makrecka-Kuka, Marina ; Liepinsh, Edgars ; Murray, Andrew J. et al. / Altered mitochondrial metabolism in the insulin-resistant heart. In: Acta physiologica (Oxford, England). 2020 ; Vol. 228, No. 3.

BibTeX

@article{0a711795bd4842308085acd102fcaeee,
title = "Altered mitochondrial metabolism in the insulin-resistant heart",
abstract = "Obesity-induced insulin resistance and type 2 diabetes mellitus can ultimately result in various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is characterized by metabolic disturbances such as impaired glucose oxidation and an increased reliance on fatty acid (FA) oxidation. Mitochondrial dysfunction has often been associated with the altered metabolic function in the diabetic heart, and may result from FA-induced lipotoxicity and uncoupling of oxidative phosphorylation. In this review, we address the metabolic changes in the diabetic heart, focusing on the loss of metabolic flexibility and cardiac mitochondrial function. We consider the alterations observed in mitochondrial substrate utilization, bioenergetics and dynamics, and highlight new areas of research which may improve our understanding of the cause and effect of cardiac mitochondrial dysfunction in diabetes. Finally, we explore how lifestyle (nutrition and exercise) and pharmacological interventions can prevent and treat metabolic and mitochondrial dysfunction in diabetes.",
keywords = "diabetes, heart, lipotoxicity, mitochondria",
author = "Marina Makrecka-Kuka and Edgars Liepinsh and Murray, {Andrew J.} and Lemieux, {H. l{\`e}ne} and Maija Dambrova and Kersti Tepp and Marju Puurand and Tuuli K{\"a}{\"a}mbre and Han, {Woo H.} and {de Goede}, Paul and O'Brien, {Katie A.} and Belma Turan and Erkan Tuncay and Yusuf Olgar and Rolo, {Anabela P.} and Palmeira, {Carlos M.} and Boardman, {Neoma T.} and W{\"u}st, {Rob C. I.} and Larsen, {Terje S.}",
year = "2020",
month = mar,
day = "1",
doi = "10.1111/apha.13430",
language = "English",
volume = "228",
journal = "Acta physiologica (Oxford, England)",
issn = "1748-1708",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Altered mitochondrial metabolism in the insulin-resistant heart

AU - Makrecka-Kuka, Marina

AU - Liepinsh, Edgars

AU - Murray, Andrew J.

AU - Lemieux, H. lène

AU - Dambrova, Maija

AU - Tepp, Kersti

AU - Puurand, Marju

AU - Käämbre, Tuuli

AU - Han, Woo H.

AU - de Goede, Paul

AU - O'Brien, Katie A.

AU - Turan, Belma

AU - Tuncay, Erkan

AU - Olgar, Yusuf

AU - Rolo, Anabela P.

AU - Palmeira, Carlos M.

AU - Boardman, Neoma T.

AU - Wüst, Rob C. I.

AU - Larsen, Terje S.

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Obesity-induced insulin resistance and type 2 diabetes mellitus can ultimately result in various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is characterized by metabolic disturbances such as impaired glucose oxidation and an increased reliance on fatty acid (FA) oxidation. Mitochondrial dysfunction has often been associated with the altered metabolic function in the diabetic heart, and may result from FA-induced lipotoxicity and uncoupling of oxidative phosphorylation. In this review, we address the metabolic changes in the diabetic heart, focusing on the loss of metabolic flexibility and cardiac mitochondrial function. We consider the alterations observed in mitochondrial substrate utilization, bioenergetics and dynamics, and highlight new areas of research which may improve our understanding of the cause and effect of cardiac mitochondrial dysfunction in diabetes. Finally, we explore how lifestyle (nutrition and exercise) and pharmacological interventions can prevent and treat metabolic and mitochondrial dysfunction in diabetes.

AB - Obesity-induced insulin resistance and type 2 diabetes mellitus can ultimately result in various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is characterized by metabolic disturbances such as impaired glucose oxidation and an increased reliance on fatty acid (FA) oxidation. Mitochondrial dysfunction has often been associated with the altered metabolic function in the diabetic heart, and may result from FA-induced lipotoxicity and uncoupling of oxidative phosphorylation. In this review, we address the metabolic changes in the diabetic heart, focusing on the loss of metabolic flexibility and cardiac mitochondrial function. We consider the alterations observed in mitochondrial substrate utilization, bioenergetics and dynamics, and highlight new areas of research which may improve our understanding of the cause and effect of cardiac mitochondrial dysfunction in diabetes. Finally, we explore how lifestyle (nutrition and exercise) and pharmacological interventions can prevent and treat metabolic and mitochondrial dysfunction in diabetes.

KW - diabetes

KW - heart

KW - lipotoxicity

KW - mitochondria

UR - http://www.scopus.com/inward/record.url?scp=85077842678&partnerID=8YFLogxK

U2 - 10.1111/apha.13430

DO - 10.1111/apha.13430

M3 - Review article

C2 - 31840389

VL - 228

JO - Acta physiologica (Oxford, England)

JF - Acta physiologica (Oxford, England)

SN - 1748-1708

IS - 3

M1 - e13430

ER -

ID: 10637021