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Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue. / Held, Ntsiki M.; Buijink, M. Renate; Elfrink, Hyung L.; Kooijman, Sander; Janssens, Georges E.; Luyf, Angela C. M.; Pras-Raves, Mia L.; Vaz, Frédéric M.; Michel, Stephan; Houtkooper, Riekelt H.; van Weeghel, Michel.

In: Scientific reports, Vol. 11, No. 1, 5932, 01.12.2021.

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@article{6ac67203c8d247fb901c53d6145b9ee8,
title = "Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue",
abstract = "Lipid metabolism is under the control of the circadian system and circadian dysregulation has been linked to obesity and dyslipidemia. These factors and outcomes have also been associated to, or affected by, the process of aging. Here, we investigated whether murine white (WAT) and brown (BAT) adipose tissue lipids exhibit rhythmicity and if this is affected by aging. To this end, we have measured the 24 h lipid profiles of WAT and BAT using a global lipidomics analysis of > 1100 lipids. We observed rhythmicity in nearly all lipid classes including glycerolipids, glycerophospholipids, sterol lipids and sphingolipids. Overall, ~ 22% of the analyzed lipids were considered rhythmic in WAT and BAT. Despite a general accumulation of lipids upon aging the fraction of oscillating lipids decreased in both tissues to 14% and 18%, respectively. Diurnal profiles of lipids in BAT appeared to depend on the lipid acyl chain length and this specific regulation was lost in aged mice. Our study revealed how aging affects the rhythmicity of lipid metabolism and could contribute to the quest for targets that improve diurnal lipid homeostasis to maintain cardiometabolic health during aging.",
author = "Held, {Ntsiki M.} and Buijink, {M. Renate} and Elfrink, {Hyung L.} and Sander Kooijman and Janssens, {Georges E.} and Luyf, {Angela C. M.} and Pras-Raves, {Mia L.} and Vaz, {Fr{\'e}d{\'e}ric M.} and Stephan Michel and Houtkooper, {Riekelt H.} and {van Weeghel}, Michel",
note = "Funding Information: This work is financially supported by Rembrandt Institute for Cardiovascular Science (to RHH) and The Netherlands Cardiovascular Research Initiative: an initiative with support of the Dutch Heart Foundation (CVON2014-02 ENERGISE). SK is funded by the Dutch Heart Foundation (2017T016), GEJ is supported by a VENI Grant from ZonMw (no. 09150161810014). RHH is funded by an ERC Starting Grant (no. 638290) and a ZonMw VIDI Grant (no. 917.15.305). Publisher Copyright: {\textcopyright} 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = dec,
day = "1",
doi = "10.1038/s41598-021-85455-4",
language = "English",
volume = "11",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue

AU - Held, Ntsiki M.

AU - Buijink, M. Renate

AU - Elfrink, Hyung L.

AU - Kooijman, Sander

AU - Janssens, Georges E.

AU - Luyf, Angela C. M.

AU - Pras-Raves, Mia L.

AU - Vaz, Frédéric M.

AU - Michel, Stephan

AU - Houtkooper, Riekelt H.

AU - van Weeghel, Michel

N1 - Funding Information: This work is financially supported by Rembrandt Institute for Cardiovascular Science (to RHH) and The Netherlands Cardiovascular Research Initiative: an initiative with support of the Dutch Heart Foundation (CVON2014-02 ENERGISE). SK is funded by the Dutch Heart Foundation (2017T016), GEJ is supported by a VENI Grant from ZonMw (no. 09150161810014). RHH is funded by an ERC Starting Grant (no. 638290) and a ZonMw VIDI Grant (no. 917.15.305). Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/12/1

Y1 - 2021/12/1

N2 - Lipid metabolism is under the control of the circadian system and circadian dysregulation has been linked to obesity and dyslipidemia. These factors and outcomes have also been associated to, or affected by, the process of aging. Here, we investigated whether murine white (WAT) and brown (BAT) adipose tissue lipids exhibit rhythmicity and if this is affected by aging. To this end, we have measured the 24 h lipid profiles of WAT and BAT using a global lipidomics analysis of > 1100 lipids. We observed rhythmicity in nearly all lipid classes including glycerolipids, glycerophospholipids, sterol lipids and sphingolipids. Overall, ~ 22% of the analyzed lipids were considered rhythmic in WAT and BAT. Despite a general accumulation of lipids upon aging the fraction of oscillating lipids decreased in both tissues to 14% and 18%, respectively. Diurnal profiles of lipids in BAT appeared to depend on the lipid acyl chain length and this specific regulation was lost in aged mice. Our study revealed how aging affects the rhythmicity of lipid metabolism and could contribute to the quest for targets that improve diurnal lipid homeostasis to maintain cardiometabolic health during aging.

AB - Lipid metabolism is under the control of the circadian system and circadian dysregulation has been linked to obesity and dyslipidemia. These factors and outcomes have also been associated to, or affected by, the process of aging. Here, we investigated whether murine white (WAT) and brown (BAT) adipose tissue lipids exhibit rhythmicity and if this is affected by aging. To this end, we have measured the 24 h lipid profiles of WAT and BAT using a global lipidomics analysis of > 1100 lipids. We observed rhythmicity in nearly all lipid classes including glycerolipids, glycerophospholipids, sterol lipids and sphingolipids. Overall, ~ 22% of the analyzed lipids were considered rhythmic in WAT and BAT. Despite a general accumulation of lipids upon aging the fraction of oscillating lipids decreased in both tissues to 14% and 18%, respectively. Diurnal profiles of lipids in BAT appeared to depend on the lipid acyl chain length and this specific regulation was lost in aged mice. Our study revealed how aging affects the rhythmicity of lipid metabolism and could contribute to the quest for targets that improve diurnal lipid homeostasis to maintain cardiometabolic health during aging.

UR - http://www.scopus.com/inward/record.url?scp=85102568462&partnerID=8YFLogxK

U2 - 10.1038/s41598-021-85455-4

DO - 10.1038/s41598-021-85455-4

M3 - Article

C2 - 33723320

VL - 11

JO - Scientific reports

JF - Scientific reports

SN - 2045-2322

IS - 1

M1 - 5932

ER -

ID: 17462350