Standard

Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study. / MARS consortium; Schouten, Laura R.; van Kaam, Anton H. et al.

In: Annals of intensive care, Vol. 9, No. 1, 55, 14.05.2019, p. 55.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

APA

Vancouver

MARS consortium, Schouten LR, van Kaam AH, Kohse F, Veltkamp F, Bos LD et al. Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study. Annals of intensive care. 2019 May 14;9(1):55. 55. doi: 10.1186/s13613-019-0529-4

Author

MARS consortium ; Schouten, Laura R. ; van Kaam, Anton H. et al. / Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study. In: Annals of intensive care. 2019 ; Vol. 9, No. 1. pp. 55.

BibTeX

@article{588d149bb816446ab8ecaf36f75a4868,
title = "Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study",
abstract = "Background: Results from preclinical studies suggest that age-dependent differences in host defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed differences in epidemiology of acute respiratory distress syndrome (ARDS) between children and adults. The present study compares biomarkers of host defense and RAS in bronchoalveolar lavage (BAL) fluid from neonates, children, adults, and older adults with ARDS. Methods: In this prospective observational study, we enrolled mechanical ventilated ARDS patients categorized into four age groups: 20 neonates (< 28 days corrected postnatal age), 29 children (28 days–18 years), 26 adults (18–65 years), and 17 older adults (> 65 years of age). All patients underwent a nondirected BAL within 72 h after intubation. Activities of the two main enzymes of RAS, angiotensin converting enzyme (ACE) and ACE2, and levels of biomarkers of inflammation, endothelial activation, and epithelial damage were determined in BAL fluid. Results: Levels of myeloperoxidase, interleukin (IL)-6, IL-10, and p-selectin were higher with increasing age, whereas intercellular adhesion molecule-1 was higher in neonates. No differences in activity of ACE and ACE2 were seen between the four age groups. Conclusions: Age-dependent differences in the levels of biomarkers in lungs of ARDS patients are present. Especially, higher levels of markers involved in the neutrophil response were found with increasing age. In contrast to preclinical studies, age is not associated with changes in the pulmonary RAS.",
author = "{MARS consortium} and Schouten, {Laura R.} and {van Kaam}, {Anton H.} and Franziska Kohse and Floor Veltkamp and Bos, {Lieuwe D.} and {de Beer}, {Friso M.} and {van Hooijdonk}, {Roosmarijn T.} and Janneke Horn and Marleen Straat and Esther Witteveen and Glas, {Gerie J.} and Luuk Wieske and {van Vught}, {Lonneke A.} and Wiewel, {Maryse A.} and Ingelse, {Sarah A.} and Bart Cortjens and {van Woensel}, {Job B.} and Bos, {Albert P.} and Thomas Walther and Schultz, {Marcus J.} and {W{\"o}sten-van Asperen}, {Roelie M.} and {de Beer}, {Friso M.} and Bos, {Lieuwe D.} and Glas, {Gerie J.} and Janneke Horn and Hoogendijk, {Arie J.} and {van Hooijdonk}, {Roosmarijn T.} and Huson, {Mischa A.} and {van der Poll}, Tom and Brendon Scicluna and Schouten, {Laura R.} and Schultz, {Marcus J.} and Marleen Straat and {van Vught}, {Lonneke A.} and Luuk Wieske and Wiewel, {Maryse A.} and Esther Witteveen and Bonten, {Marc J.} and Cremer, {Olaf L.} and Frencken, {Jos F.} and {van de Groep}, Kirsten and {Klein Klouwenberg}, {Peter M.} and Koster-Brouwer, {Maria E.} and Ong, {David S.} and Verboom, {Diana M.}",
year = "2019",
month = may,
day = "14",
doi = "10.1186/s13613-019-0529-4",
language = "English",
volume = "9",
pages = "55",
journal = "Annals of intensive care",
issn = "2110-5820",
publisher = "Springer-Verlag GmbH and Co. KG",
number = "1",

}

RIS

TY - JOUR

T1 - Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study

AU - MARS consortium

AU - Schouten, Laura R.

AU - van Kaam, Anton H.

AU - Kohse, Franziska

AU - Veltkamp, Floor

AU - Bos, Lieuwe D.

AU - de Beer, Friso M.

AU - van Hooijdonk, Roosmarijn T.

AU - Horn, Janneke

AU - Straat, Marleen

AU - Witteveen, Esther

AU - Glas, Gerie J.

AU - Wieske, Luuk

AU - van Vught, Lonneke A.

AU - Wiewel, Maryse A.

AU - Ingelse, Sarah A.

AU - Cortjens, Bart

AU - van Woensel, Job B.

AU - Bos, Albert P.

AU - Walther, Thomas

AU - Schultz, Marcus J.

AU - Wösten-van Asperen, Roelie M.

AU - de Beer, Friso M.

AU - Bos, Lieuwe D.

AU - Glas, Gerie J.

AU - Horn, Janneke

AU - Hoogendijk, Arie J.

AU - van Hooijdonk, Roosmarijn T.

AU - Huson, Mischa A.

AU - van der Poll, Tom

AU - Scicluna, Brendon

AU - Schouten, Laura R.

AU - Schultz, Marcus J.

AU - Straat, Marleen

AU - van Vught, Lonneke A.

AU - Wieske, Luuk

AU - Wiewel, Maryse A.

AU - Witteveen, Esther

AU - Bonten, Marc J.

AU - Cremer, Olaf L.

AU - Frencken, Jos F.

AU - van de Groep, Kirsten

AU - Klein Klouwenberg, Peter M.

AU - Koster-Brouwer, Maria E.

AU - Ong, David S.

AU - Verboom, Diana M.

PY - 2019/5/14

Y1 - 2019/5/14

N2 - Background: Results from preclinical studies suggest that age-dependent differences in host defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed differences in epidemiology of acute respiratory distress syndrome (ARDS) between children and adults. The present study compares biomarkers of host defense and RAS in bronchoalveolar lavage (BAL) fluid from neonates, children, adults, and older adults with ARDS. Methods: In this prospective observational study, we enrolled mechanical ventilated ARDS patients categorized into four age groups: 20 neonates (< 28 days corrected postnatal age), 29 children (28 days–18 years), 26 adults (18–65 years), and 17 older adults (> 65 years of age). All patients underwent a nondirected BAL within 72 h after intubation. Activities of the two main enzymes of RAS, angiotensin converting enzyme (ACE) and ACE2, and levels of biomarkers of inflammation, endothelial activation, and epithelial damage were determined in BAL fluid. Results: Levels of myeloperoxidase, interleukin (IL)-6, IL-10, and p-selectin were higher with increasing age, whereas intercellular adhesion molecule-1 was higher in neonates. No differences in activity of ACE and ACE2 were seen between the four age groups. Conclusions: Age-dependent differences in the levels of biomarkers in lungs of ARDS patients are present. Especially, higher levels of markers involved in the neutrophil response were found with increasing age. In contrast to preclinical studies, age is not associated with changes in the pulmonary RAS.

AB - Background: Results from preclinical studies suggest that age-dependent differences in host defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed differences in epidemiology of acute respiratory distress syndrome (ARDS) between children and adults. The present study compares biomarkers of host defense and RAS in bronchoalveolar lavage (BAL) fluid from neonates, children, adults, and older adults with ARDS. Methods: In this prospective observational study, we enrolled mechanical ventilated ARDS patients categorized into four age groups: 20 neonates (< 28 days corrected postnatal age), 29 children (28 days–18 years), 26 adults (18–65 years), and 17 older adults (> 65 years of age). All patients underwent a nondirected BAL within 72 h after intubation. Activities of the two main enzymes of RAS, angiotensin converting enzyme (ACE) and ACE2, and levels of biomarkers of inflammation, endothelial activation, and epithelial damage were determined in BAL fluid. Results: Levels of myeloperoxidase, interleukin (IL)-6, IL-10, and p-selectin were higher with increasing age, whereas intercellular adhesion molecule-1 was higher in neonates. No differences in activity of ACE and ACE2 were seen between the four age groups. Conclusions: Age-dependent differences in the levels of biomarkers in lungs of ARDS patients are present. Especially, higher levels of markers involved in the neutrophil response were found with increasing age. In contrast to preclinical studies, age is not associated with changes in the pulmonary RAS.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85065813716&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/31089908

U2 - 10.1186/s13613-019-0529-4

DO - 10.1186/s13613-019-0529-4

M3 - Article

C2 - 31089908

VL - 9

SP - 55

JO - Annals of intensive care

JF - Annals of intensive care

SN - 2110-5820

IS - 1

M1 - 55

ER -

ID: 6453470