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After-Effects of Time-Restricted Feeding on Whole-Body Metabolism and Gene Expression in Four Different Peripheral Tissues. / de Goede, Paul; Hellings, Tom P.; Coopmans, Tom V. et al.

In: Obesity (Silver Spring, Md.), Vol. 28, No. S1, 01.07.2020, p. S68-S80.

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de Goede P, Hellings TP, Coopmans TV, Ritsema WIGR, Kalsbeek A. After-Effects of Time-Restricted Feeding on Whole-Body Metabolism and Gene Expression in Four Different Peripheral Tissues. Obesity (Silver Spring, Md.). 2020 Jul 1;28(S1):S68-S80. Epub 2020. doi: 10.1002/oby.22830

Author

de Goede, Paul ; Hellings, Tom P. ; Coopmans, Tom V. et al. / After-Effects of Time-Restricted Feeding on Whole-Body Metabolism and Gene Expression in Four Different Peripheral Tissues. In: Obesity (Silver Spring, Md.). 2020 ; Vol. 28, No. S1. pp. S68-S80.

BibTeX

@article{af68997dfca5424cb9cd53d179eb5708,
title = "After-Effects of Time-Restricted Feeding on Whole-Body Metabolism and Gene Expression in Four Different Peripheral Tissues",
abstract = "Objective: Epidemiological studies show that shift workers are at increased risk for type 2 diabetes. As modern societies increasingly require shift work, it seems crucial to determine whether there are long-lasting health effects of rotational shifts. Methods: This study examined the after-effects of 4 weeks of time-restricted feeding (TRF) during the light period (= light-fed) in rats, an animal model for shift work. This study also included a TRF-dark (= dark-fed) control group. The aligned and misaligned feeding times of light and dark feeding are associated with poor and good health outcomes, respectively. Several physiological measures were monitored continuously; blood, liver, brown adipose tissue and soleus and gastrocnemius muscle were collected following 11 days of ad libitum (AL) feeding after ending the TRF. Results: In the dark-fed animals, the day/night differences in food intake, activity, and respiratory exchange ratio were still enhanced at the end of the experiment. Light-fed animals displayed the smallest day/night differences for these measures, as well as for body temperature. In both the light- and dark-fed animals, rhythms in plasma glucose, nonesterified fatty acids, and gene expression had not fully recovered after 11 days of AL feeding. Importantly, the effects on gene expression were both tissue- and gene-dependent. Conclusions: Our data indicate that rotational shift workers may have an increased risk of long-lasting disturbed rhythms in several physiological measures after a period of shift work. Clearly, such disturbances may harm their health.",
author = "{de Goede}, Paul and Hellings, {Tom P.} and Coopmans, {Tom V.} and Ritsema, {Wayne I. G. R.} and Andries Kalsbeek",
year = "2020",
month = jul,
day = "1",
doi = "10.1002/oby.22830",
language = "English",
volume = "28",
pages = "S68--S80",
journal = "Obesity (Silver Spring, Md.)",
issn = "1930-7381",
publisher = "North American Association for the Study of Obesity",
number = "S1",

}

RIS

TY - JOUR

T1 - After-Effects of Time-Restricted Feeding on Whole-Body Metabolism and Gene Expression in Four Different Peripheral Tissues

AU - de Goede, Paul

AU - Hellings, Tom P.

AU - Coopmans, Tom V.

AU - Ritsema, Wayne I. G. R.

AU - Kalsbeek, Andries

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Objective: Epidemiological studies show that shift workers are at increased risk for type 2 diabetes. As modern societies increasingly require shift work, it seems crucial to determine whether there are long-lasting health effects of rotational shifts. Methods: This study examined the after-effects of 4 weeks of time-restricted feeding (TRF) during the light period (= light-fed) in rats, an animal model for shift work. This study also included a TRF-dark (= dark-fed) control group. The aligned and misaligned feeding times of light and dark feeding are associated with poor and good health outcomes, respectively. Several physiological measures were monitored continuously; blood, liver, brown adipose tissue and soleus and gastrocnemius muscle were collected following 11 days of ad libitum (AL) feeding after ending the TRF. Results: In the dark-fed animals, the day/night differences in food intake, activity, and respiratory exchange ratio were still enhanced at the end of the experiment. Light-fed animals displayed the smallest day/night differences for these measures, as well as for body temperature. In both the light- and dark-fed animals, rhythms in plasma glucose, nonesterified fatty acids, and gene expression had not fully recovered after 11 days of AL feeding. Importantly, the effects on gene expression were both tissue- and gene-dependent. Conclusions: Our data indicate that rotational shift workers may have an increased risk of long-lasting disturbed rhythms in several physiological measures after a period of shift work. Clearly, such disturbances may harm their health.

AB - Objective: Epidemiological studies show that shift workers are at increased risk for type 2 diabetes. As modern societies increasingly require shift work, it seems crucial to determine whether there are long-lasting health effects of rotational shifts. Methods: This study examined the after-effects of 4 weeks of time-restricted feeding (TRF) during the light period (= light-fed) in rats, an animal model for shift work. This study also included a TRF-dark (= dark-fed) control group. The aligned and misaligned feeding times of light and dark feeding are associated with poor and good health outcomes, respectively. Several physiological measures were monitored continuously; blood, liver, brown adipose tissue and soleus and gastrocnemius muscle were collected following 11 days of ad libitum (AL) feeding after ending the TRF. Results: In the dark-fed animals, the day/night differences in food intake, activity, and respiratory exchange ratio were still enhanced at the end of the experiment. Light-fed animals displayed the smallest day/night differences for these measures, as well as for body temperature. In both the light- and dark-fed animals, rhythms in plasma glucose, nonesterified fatty acids, and gene expression had not fully recovered after 11 days of AL feeding. Importantly, the effects on gene expression were both tissue- and gene-dependent. Conclusions: Our data indicate that rotational shift workers may have an increased risk of long-lasting disturbed rhythms in several physiological measures after a period of shift work. Clearly, such disturbances may harm their health.

UR - http://www.scopus.com/inward/record.url?scp=85085621077&partnerID=8YFLogxK

U2 - 10.1002/oby.22830

DO - 10.1002/oby.22830

M3 - Article

C2 - 32475077

VL - 28

SP - S68-S80

JO - Obesity (Silver Spring, Md.)

JF - Obesity (Silver Spring, Md.)

SN - 1930-7381

IS - S1

ER -

ID: 11728846