Standard

Adverse events of local treatment in long-term head and neck rhabdomyosarcoma survivors after external beam radiotherapy or AMORE treatment. / Schoot, Reineke A.; Slater, Olga; Ronckers, Cécile M.; Zwinderman, Aeilko H.; Balm, Alfons J. M.; Hartley, Benjamin; van den Brekel, Michiel W.; Gupta, Sanjeev; Saeed, Peerooz; Gajdosova, Eva; Pieters, Bradley R.; Gaze, Mark N.; Mandeville, Henry C.; Fajardo, Raquel Davila; Chang, Yen Ch'ing; Gains, Jennifer E.; Strackee, Simon D.; Dunaway, David; Abela, Christopher; Mason, Carol; Smeele, Ludi E.; Chisholm, Julia C.; Levitt, Gill A.; Kremer, Leontien C. M.; Grootenhuis, Martha A.; Maurice-Stam, Heleen; Stiller, Charles A.; Hammond, Peter; Caron, Huib N.; Merks, Johannes H. M.

In: European journal of cancer (Oxford, England, Vol. 51, No. 11, 2015, p. 1424-1434.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

Schoot, RA, Slater, O, Ronckers, CM, Zwinderman, AH, Balm, AJM, Hartley, B, van den Brekel, MW, Gupta, S, Saeed, P, Gajdosova, E, Pieters, BR, Gaze, MN, Mandeville, HC, Fajardo, RD, Chang, YC, Gains, JE, Strackee, SD, Dunaway, D, Abela, C, Mason, C, Smeele, LE, Chisholm, JC, Levitt, GA, Kremer, LCM, Grootenhuis, MA, Maurice-Stam, H, Stiller, CA, Hammond, P, Caron, HN & Merks, JHM 2015, 'Adverse events of local treatment in long-term head and neck rhabdomyosarcoma survivors after external beam radiotherapy or AMORE treatment', European journal of cancer (Oxford, England, vol. 51, no. 11, pp. 1424-1434. https://doi.org/10.1016/j.ejca.2015.02.010

APA

Schoot, R. A., Slater, O., Ronckers, C. M., Zwinderman, A. H., Balm, A. J. M., Hartley, B., van den Brekel, M. W., Gupta, S., Saeed, P., Gajdosova, E., Pieters, B. R., Gaze, M. N., Mandeville, H. C., Fajardo, R. D., Chang, Y. C., Gains, J. E., Strackee, S. D., Dunaway, D., Abela, C., ... Merks, J. H. M. (2015). Adverse events of local treatment in long-term head and neck rhabdomyosarcoma survivors after external beam radiotherapy or AMORE treatment. European journal of cancer (Oxford, England, 51(11), 1424-1434. https://doi.org/10.1016/j.ejca.2015.02.010

Vancouver

Author

Schoot, Reineke A. ; Slater, Olga ; Ronckers, Cécile M. ; Zwinderman, Aeilko H. ; Balm, Alfons J. M. ; Hartley, Benjamin ; van den Brekel, Michiel W. ; Gupta, Sanjeev ; Saeed, Peerooz ; Gajdosova, Eva ; Pieters, Bradley R. ; Gaze, Mark N. ; Mandeville, Henry C. ; Fajardo, Raquel Davila ; Chang, Yen Ch'ing ; Gains, Jennifer E. ; Strackee, Simon D. ; Dunaway, David ; Abela, Christopher ; Mason, Carol ; Smeele, Ludi E. ; Chisholm, Julia C. ; Levitt, Gill A. ; Kremer, Leontien C. M. ; Grootenhuis, Martha A. ; Maurice-Stam, Heleen ; Stiller, Charles A. ; Hammond, Peter ; Caron, Huib N. ; Merks, Johannes H. M. / Adverse events of local treatment in long-term head and neck rhabdomyosarcoma survivors after external beam radiotherapy or AMORE treatment. In: European journal of cancer (Oxford, England. 2015 ; Vol. 51, No. 11. pp. 1424-1434.

BibTeX

@article{590df152c93043a48a47cdb36d91243b,
title = "Adverse events of local treatment in long-term head and neck rhabdomyosarcoma survivors after external beam radiotherapy or AMORE treatment",
abstract = "Radiotherapy is a well-known cause of adverse events (AEs). To reduce AEs, an innovative local treatment was developed in Amsterdam: Ablative surgery, MOuld brachytherapy and surgical REconstruction (AMORE). (1) to determine the prevalence of AEs in HNRMS survivors and (2) to compare AEs between survivors treated with the international standard: external beam radiotherapy (EBRT-based: London) and survivors treated with AMORE if feasible, otherwise EBRT (AMORE-based: Amsterdam). All HNRMS survivors, treated in London or Amsterdam between January 1990 and December 2010 (n = 153), and alive ⩾ 2 years post-treatment were eligible (n = 113). A predefined list of AEs was assessed in a multidisciplinary clinic and graded according to the Common Terminology Criteria for Adverse Events. Eighty HNRMS survivors attended the clinic (median follow-up 10.5 years); 63% experienced ⩾ 1 severe or disabling event, and 76% had ⩾ 5 AEs (any grade). Survivors with EBRT-based treatment were, after adjustment for site, age at diagnosis, and follow-up duration, at increased risk to develop any grade 3/4 event or ⩾ 5 AEs (any grade) compared with survivors with AMORE-based treatments (p = 0.032 and 0.01, respectively). Five year overall survival (source population) after EBRT-based treatment was 75.0%, after AMORE-based treatment 76.9%, p = 0.56. This study may serve as a baseline inventory and can be used in future studies for prospective assessments of AEs following the introduction of novel local treatment modalities. AMORE-based local treatment resulted in similar overall survival and a reduction of AEs secondary to local treatment",
author = "Schoot, {Reineke A.} and Olga Slater and Ronckers, {C{\'e}cile M.} and Zwinderman, {Aeilko H.} and Balm, {Alfons J. M.} and Benjamin Hartley and {van den Brekel}, {Michiel W.} and Sanjeev Gupta and Peerooz Saeed and Eva Gajdosova and Pieters, {Bradley R.} and Gaze, {Mark N.} and Mandeville, {Henry C.} and Fajardo, {Raquel Davila} and Chang, {Yen Ch'ing} and Gains, {Jennifer E.} and Strackee, {Simon D.} and David Dunaway and Christopher Abela and Carol Mason and Smeele, {Ludi E.} and Chisholm, {Julia C.} and Levitt, {Gill A.} and Kremer, {Leontien C. M.} and Grootenhuis, {Martha A.} and Heleen Maurice-Stam and Stiller, {Charles A.} and Peter Hammond and Caron, {Huib N.} and Merks, {Johannes H. M.}",
year = "2015",
doi = "10.1016/j.ejca.2015.02.010",
language = "English",
volume = "51",
pages = "1424--1434",
journal = "European journal of cancer (Oxford, England",
issn = "0959-8049",
publisher = "Elsevier Limited",
number = "11",

}

RIS

TY - JOUR

T1 - Adverse events of local treatment in long-term head and neck rhabdomyosarcoma survivors after external beam radiotherapy or AMORE treatment

AU - Schoot, Reineke A.

AU - Slater, Olga

AU - Ronckers, Cécile M.

AU - Zwinderman, Aeilko H.

AU - Balm, Alfons J. M.

AU - Hartley, Benjamin

AU - van den Brekel, Michiel W.

AU - Gupta, Sanjeev

AU - Saeed, Peerooz

AU - Gajdosova, Eva

AU - Pieters, Bradley R.

AU - Gaze, Mark N.

AU - Mandeville, Henry C.

AU - Fajardo, Raquel Davila

AU - Chang, Yen Ch'ing

AU - Gains, Jennifer E.

AU - Strackee, Simon D.

AU - Dunaway, David

AU - Abela, Christopher

AU - Mason, Carol

AU - Smeele, Ludi E.

AU - Chisholm, Julia C.

AU - Levitt, Gill A.

AU - Kremer, Leontien C. M.

AU - Grootenhuis, Martha A.

AU - Maurice-Stam, Heleen

AU - Stiller, Charles A.

AU - Hammond, Peter

AU - Caron, Huib N.

AU - Merks, Johannes H. M.

PY - 2015

Y1 - 2015

N2 - Radiotherapy is a well-known cause of adverse events (AEs). To reduce AEs, an innovative local treatment was developed in Amsterdam: Ablative surgery, MOuld brachytherapy and surgical REconstruction (AMORE). (1) to determine the prevalence of AEs in HNRMS survivors and (2) to compare AEs between survivors treated with the international standard: external beam radiotherapy (EBRT-based: London) and survivors treated with AMORE if feasible, otherwise EBRT (AMORE-based: Amsterdam). All HNRMS survivors, treated in London or Amsterdam between January 1990 and December 2010 (n = 153), and alive ⩾ 2 years post-treatment were eligible (n = 113). A predefined list of AEs was assessed in a multidisciplinary clinic and graded according to the Common Terminology Criteria for Adverse Events. Eighty HNRMS survivors attended the clinic (median follow-up 10.5 years); 63% experienced ⩾ 1 severe or disabling event, and 76% had ⩾ 5 AEs (any grade). Survivors with EBRT-based treatment were, after adjustment for site, age at diagnosis, and follow-up duration, at increased risk to develop any grade 3/4 event or ⩾ 5 AEs (any grade) compared with survivors with AMORE-based treatments (p = 0.032 and 0.01, respectively). Five year overall survival (source population) after EBRT-based treatment was 75.0%, after AMORE-based treatment 76.9%, p = 0.56. This study may serve as a baseline inventory and can be used in future studies for prospective assessments of AEs following the introduction of novel local treatment modalities. AMORE-based local treatment resulted in similar overall survival and a reduction of AEs secondary to local treatment

AB - Radiotherapy is a well-known cause of adverse events (AEs). To reduce AEs, an innovative local treatment was developed in Amsterdam: Ablative surgery, MOuld brachytherapy and surgical REconstruction (AMORE). (1) to determine the prevalence of AEs in HNRMS survivors and (2) to compare AEs between survivors treated with the international standard: external beam radiotherapy (EBRT-based: London) and survivors treated with AMORE if feasible, otherwise EBRT (AMORE-based: Amsterdam). All HNRMS survivors, treated in London or Amsterdam between January 1990 and December 2010 (n = 153), and alive ⩾ 2 years post-treatment were eligible (n = 113). A predefined list of AEs was assessed in a multidisciplinary clinic and graded according to the Common Terminology Criteria for Adverse Events. Eighty HNRMS survivors attended the clinic (median follow-up 10.5 years); 63% experienced ⩾ 1 severe or disabling event, and 76% had ⩾ 5 AEs (any grade). Survivors with EBRT-based treatment were, after adjustment for site, age at diagnosis, and follow-up duration, at increased risk to develop any grade 3/4 event or ⩾ 5 AEs (any grade) compared with survivors with AMORE-based treatments (p = 0.032 and 0.01, respectively). Five year overall survival (source population) after EBRT-based treatment was 75.0%, after AMORE-based treatment 76.9%, p = 0.56. This study may serve as a baseline inventory and can be used in future studies for prospective assessments of AEs following the introduction of novel local treatment modalities. AMORE-based local treatment resulted in similar overall survival and a reduction of AEs secondary to local treatment

U2 - 10.1016/j.ejca.2015.02.010

DO - 10.1016/j.ejca.2015.02.010

M3 - Article

C2 - 25998323

VL - 51

SP - 1424

EP - 1434

JO - European journal of cancer (Oxford, England

JF - European journal of cancer (Oxford, England

SN - 0959-8049

IS - 11

ER -

ID: 2629637