Standard

Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease. / Munneke, J. Marius; Björklund, Andreas T.; Mjösberg, Jenny M. et al.

In: Blood, Vol. 124, No. 5, 2014, p. 812-821.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

APA

Vancouver

Author

BibTeX

@article{7db37f0a138c423694699e60a618f24c,
title = "Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease",
abstract = "Allogeneic hematopoietic stem cell transplantation (HSCT) is widely used to treat hematopoietic cell disorders but is often complicated by graft-versus-host disease (GVHD), which causes severe epithelial damage. Here we have investigated longitudinally the effects of induction chemotherapy, conditioning radiochemotherapy, and allogeneic HSCT on composition, phenotype, and recovery of circulating innate lymphoid cells (ILCs) in 51 acute leukemia patients. We found that reconstitution of ILC1, ILC2, and NCR(-)ILC3 was slow compared with that of neutrophils and monocytes. NCR+ ILC3 cells, which are not present in the circulation of healthy persons, appeared both after induction chemotherapy and after allogeneic HSCT. Circulating patient ILCs before transplantation, as well as donor ILCs after transplantation, expressed activation (CD69), proliferation (Ki-67), and tissue homing markers for gut (alpha 4 beta 7, CCR6) and skin (CCR10 and CLA). The proportion of ILCs expressing these markers was associated with a decreased susceptibility to therapy-induced mucositis and acute GVHD. Taken together, these data suggest that ILC recovery and treatment-related tissue damage are interrelated and affect the development of GVHD",
author = "Munneke, {J. Marius} and Bj{\"o}rklund, {Andreas T.} and Mj{\"o}sberg, {Jenny M.} and Karin Garming-Legert and Bernink, {Jochem H.} and Bianca Blom and Cynthia Huisman and {van Oers}, {Marinus H. J.} and Hergen Spits and Karl-Johan Malmberg and Hazenberg, {Mette D.}",
year = "2014",
doi = "10.1182/blood-2013-11-536888",
language = "English",
volume = "124",
pages = "812--821",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "5",

}

RIS

TY - JOUR

T1 - Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease

AU - Munneke, J. Marius

AU - Björklund, Andreas T.

AU - Mjösberg, Jenny M.

AU - Garming-Legert, Karin

AU - Bernink, Jochem H.

AU - Blom, Bianca

AU - Huisman, Cynthia

AU - van Oers, Marinus H. J.

AU - Spits, Hergen

AU - Malmberg, Karl-Johan

AU - Hazenberg, Mette D.

PY - 2014

Y1 - 2014

N2 - Allogeneic hematopoietic stem cell transplantation (HSCT) is widely used to treat hematopoietic cell disorders but is often complicated by graft-versus-host disease (GVHD), which causes severe epithelial damage. Here we have investigated longitudinally the effects of induction chemotherapy, conditioning radiochemotherapy, and allogeneic HSCT on composition, phenotype, and recovery of circulating innate lymphoid cells (ILCs) in 51 acute leukemia patients. We found that reconstitution of ILC1, ILC2, and NCR(-)ILC3 was slow compared with that of neutrophils and monocytes. NCR+ ILC3 cells, which are not present in the circulation of healthy persons, appeared both after induction chemotherapy and after allogeneic HSCT. Circulating patient ILCs before transplantation, as well as donor ILCs after transplantation, expressed activation (CD69), proliferation (Ki-67), and tissue homing markers for gut (alpha 4 beta 7, CCR6) and skin (CCR10 and CLA). The proportion of ILCs expressing these markers was associated with a decreased susceptibility to therapy-induced mucositis and acute GVHD. Taken together, these data suggest that ILC recovery and treatment-related tissue damage are interrelated and affect the development of GVHD

AB - Allogeneic hematopoietic stem cell transplantation (HSCT) is widely used to treat hematopoietic cell disorders but is often complicated by graft-versus-host disease (GVHD), which causes severe epithelial damage. Here we have investigated longitudinally the effects of induction chemotherapy, conditioning radiochemotherapy, and allogeneic HSCT on composition, phenotype, and recovery of circulating innate lymphoid cells (ILCs) in 51 acute leukemia patients. We found that reconstitution of ILC1, ILC2, and NCR(-)ILC3 was slow compared with that of neutrophils and monocytes. NCR+ ILC3 cells, which are not present in the circulation of healthy persons, appeared both after induction chemotherapy and after allogeneic HSCT. Circulating patient ILCs before transplantation, as well as donor ILCs after transplantation, expressed activation (CD69), proliferation (Ki-67), and tissue homing markers for gut (alpha 4 beta 7, CCR6) and skin (CCR10 and CLA). The proportion of ILCs expressing these markers was associated with a decreased susceptibility to therapy-induced mucositis and acute GVHD. Taken together, these data suggest that ILC recovery and treatment-related tissue damage are interrelated and affect the development of GVHD

U2 - 10.1182/blood-2013-11-536888

DO - 10.1182/blood-2013-11-536888

M3 - Article

C2 - 24855210

VL - 124

SP - 812

EP - 821

JO - Blood

JF - Blood

SN - 0006-4971

IS - 5

ER -

ID: 2412339