Abnormal Right Ventricular Myocardial Performance Index Is Not Associated With Outcomes in Invasively Ventilated Intensive Care Unit Patients Without Acute Respiratory Distress Syndrome—Post hoc Analysis of Two RCTs

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Abnormal Right Ventricular Myocardial Performance Index Is Not Associated With Outcomes in Invasively Ventilated Intensive Care Unit Patients Without Acute Respiratory Distress Syndrome—Post hoc Analysis of Two RCTs. / Pierrakos, Charalampos; Geke Algera, Anna; Simonis, Fabienne et al.

In: Frontiers in cardiovascular medicine, Vol. 9, 830165, 31.05.2022, p. 830165.

Research output: Contribution to journal › Article › Academic › peer-review

BibTeX

@article{388ccf4ee3b34efc8c1224793300ac0d,

title = "Abnormal Right Ventricular Myocardial Performance Index Is Not Associated With Outcomes in Invasively Ventilated Intensive Care Unit Patients Without Acute Respiratory Distress Syndrome—Post hoc Analysis of Two RCTs",

abstract = "Background: The objective of the study was to determine the association between right ventricular (RV) myocardial performance index (MPI) and successful liberation from the ventilator and death within 28 days. Methods: Post hoc analysis of 2 ventilation studies in invasively ventilated patients not having ARDS. RV-MPI was collected through transthoracic echocardiography within 24–48 h from the start of invasive ventilation according to the study protocols. RV-MPI ≤ 0.54 was considered normal. The primary endpoint was successful liberation from the ventilator < 28 days; the secondary endpoint was 28-day mortality. Results: A total of 81 patients underwent transthoracic echocardiography at median 30 (24–42) h after the start of ventilation—in 73 (90%) patients, the RV-MPI could be collected. A total of 56 (77%) patients were successfully liberated from the ventilator < 28 days; A total of 22 (30%) patients had died before or at day 28. A total of 18 (25%) patients had an abnormal RV-MPI. RV-MPI was neither associated with successful liberation from the ventilator within 28 days [HR, 2.2 (95% CI 0.47–10.6); p = 0.31] nor with 28-day mortality [HR, 1.56 (95% CI 0.07–34.27); p = 0.7]. Conclusion: In invasively ventilated critically ill patients without ARDS, an abnormal RV-MPI indicative of RV dysfunction was not associated with time to liberation from invasive ventilation.",

keywords = "echocardiography, heart-lung interactions, hemodynamic monitoring, mechanical ventilation, mortality, successful extubation",

author = "Charalampos Pierrakos and {Geke Algera}, Anna and Fabienne Simonis and Cherpanath, {Thomas G. V.} and Lagrand, {Wim K.} and Frederique Paulus and Bos, {Lieuwe D. J.} and {the PReVENT– and RELAx–Investigators} and Schultz, {Marcus J.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Pierrakos, Geke Algera, Simonis, Cherpanath, Lagrand, Paulus, Bos and Schultz.",

year = "2022",

month = may,

day = "31",

doi = "10.3389/fcvm.2022.830165",

language = "English",

volume = "9",

pages = "830165",

journal = "Frontiers in cardiovascular medicine",

issn = "2297-055X",

publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Abnormal Right Ventricular Myocardial Performance Index Is Not Associated With Outcomes in Invasively Ventilated Intensive Care Unit Patients Without Acute Respiratory Distress Syndrome—Post hoc Analysis of Two RCTs

AU - Pierrakos, Charalampos

AU - Geke Algera, Anna

AU - Simonis, Fabienne

AU - Cherpanath, Thomas G. V.

AU - Lagrand, Wim K.

AU - Paulus, Frederique

AU - Bos, Lieuwe D. J.

AU - the PReVENT– and RELAx–Investigators

AU - Schultz, Marcus J.

PY - 2022/5/31

Y1 - 2022/5/31

N2 - Background: The objective of the study was to determine the association between right ventricular (RV) myocardial performance index (MPI) and successful liberation from the ventilator and death within 28 days. Methods: Post hoc analysis of 2 ventilation studies in invasively ventilated patients not having ARDS. RV-MPI was collected through transthoracic echocardiography within 24–48 h from the start of invasive ventilation according to the study protocols. RV-MPI ≤ 0.54 was considered normal. The primary endpoint was successful liberation from the ventilator < 28 days; the secondary endpoint was 28-day mortality. Results: A total of 81 patients underwent transthoracic echocardiography at median 30 (24–42) h after the start of ventilation—in 73 (90%) patients, the RV-MPI could be collected. A total of 56 (77%) patients were successfully liberated from the ventilator < 28 days; A total of 22 (30%) patients had died before or at day 28. A total of 18 (25%) patients had an abnormal RV-MPI. RV-MPI was neither associated with successful liberation from the ventilator within 28 days [HR, 2.2 (95% CI 0.47–10.6); p = 0.31] nor with 28-day mortality [HR, 1.56 (95% CI 0.07–34.27); p = 0.7]. Conclusion: In invasively ventilated critically ill patients without ARDS, an abnormal RV-MPI indicative of RV dysfunction was not associated with time to liberation from invasive ventilation.

AB - Background: The objective of the study was to determine the association between right ventricular (RV) myocardial performance index (MPI) and successful liberation from the ventilator and death within 28 days. Methods: Post hoc analysis of 2 ventilation studies in invasively ventilated patients not having ARDS. RV-MPI was collected through transthoracic echocardiography within 24–48 h from the start of invasive ventilation according to the study protocols. RV-MPI ≤ 0.54 was considered normal. The primary endpoint was successful liberation from the ventilator < 28 days; the secondary endpoint was 28-day mortality. Results: A total of 81 patients underwent transthoracic echocardiography at median 30 (24–42) h after the start of ventilation—in 73 (90%) patients, the RV-MPI could be collected. A total of 56 (77%) patients were successfully liberated from the ventilator < 28 days; A total of 22 (30%) patients had died before or at day 28. A total of 18 (25%) patients had an abnormal RV-MPI. RV-MPI was neither associated with successful liberation from the ventilator within 28 days [HR, 2.2 (95% CI 0.47–10.6); p = 0.31] nor with 28-day mortality [HR, 1.56 (95% CI 0.07–34.27); p = 0.7]. Conclusion: In invasively ventilated critically ill patients without ARDS, an abnormal RV-MPI indicative of RV dysfunction was not associated with time to liberation from invasive ventilation.

KW - echocardiography

KW - heart-lung interactions

KW - hemodynamic monitoring

KW - mechanical ventilation

KW - mortality

KW - successful extubation

UR - http://www.scopus.com/inward/record.url?scp=85138657663&partnerID=8YFLogxK

U2 - 10.3389/fcvm.2022.830165

DO - 10.3389/fcvm.2022.830165

M3 - Article

C2 - 35711375

VL - 9

SP - 830165

JO - Frontiers in cardiovascular medicine

JF - Frontiers in cardiovascular medicine

SN - 2297-055X

M1 - 830165

ER -

ID: 26183544

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