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TY - JOUR

T1 - A highly virulent variant of HIV-1 circulating in the Netherlands

AU - Wymant, Chris

AU - Bezemer, Daniela

AU - Blanquart, François

AU - Ferretti, Luca

AU - Gall, Astrid

AU - Hall, Matthew

AU - Golubchik, Tanya

AU - Bakker, Margreet

AU - Ong, Swee Hoe

AU - Zhao, Lele

AU - Bonsall, David

AU - de Cesare, Mariateresa

AU - MacIntyre-Cockett, George

AU - Abeler-Dörner, Lucie

AU - Albert, Jan

AU - Bannert, Norbert

AU - Fellay, Jacques

AU - Grabowski, M. Kate

AU - Gunsenheimer-Bartmeyer, Barbara

AU - Günthard, Huldrych F.

AU - Kivelä, Pia

AU - Kouyos, Roger D.

AU - Laeyendecker, Oliver

AU - Meyer, Laurence

AU - Porter, Kholoud

AU - Ristola, Matti

AU - van Sighem, Ard

AU - Berkhout, Ben

AU - Kellam, Paul

AU - Netherlands ATHENA HIV Observational Cohort

AU - Cornelissen, Marion

AU - BEEHIVE Collaboration

AU - Reiss, Peter

AU - Fraser, Christophe

N1 - Funding Information: This study was funded by ERC Advanced Grant PBDR-339251 and a Li Ka Shing Foundation grant, both awarded to C.F. The ATHENA Cohort is managed by Stichting HIV Monitoring and supported by a grant from the Dutch Ministry of Health, Welfare and Sport through the Centre for Infectious Disease Control of the National Institute for Public Health and the Environment. Publisher Copyright: Copyright © 2022 The Authors, some rights reserved.

PY - 2022/2/4

Y1 - 2022/2/4

N2 - We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV - CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences - is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.

AB - We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV - CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences - is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.

UR - http://www.scopus.com/inward/record.url?scp=85124019619&partnerID=8YFLogxK

U2 - 10.1126/science.abk1688

DO - 10.1126/science.abk1688

M3 - Article

C2 - 35113714

VL - 375

SP - 540

EP - 545

JO - Science

JF - Science

SN - 0036-8075

IS - 6580

M1 - A30

ER -