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36-month clinical outcomes of patients with venous thromboembolism : GARFIELD-VTE. / GARFIELD-VTE investigators.

In: Thrombosis research, Vol. 222, 01.02.2023, p. 31-39.

Research output: Contribution to journal › Article › Academic › peer-review

Harvard

GARFIELD-VTE investigators 2023, '36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE', Thrombosis research, vol. 222, pp. 31-39. https://doi.org/10.1016/j.thromres.2022.11.016

APA

GARFIELD-VTE investigators (2023). 36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE. Thrombosis research, 222, 31-39. https://doi.org/10.1016/j.thromres.2022.11.016

Vancouver

GARFIELD-VTE investigators. 36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE. Thrombosis research. 2023 Feb 1;222:31-39. doi: 10.1016/j.thromres.2022.11.016

Author

GARFIELD-VTE investigators. / 36-month clinical outcomes of patients with venous thromboembolism : GARFIELD-VTE. In: Thrombosis research. 2023 ; Vol. 222. pp. 31-39.

BibTeX

@article{b937d3366b334ba5b05dc372959e857b,
title = "36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE",
abstract = "Background: Venous thromboembolism (VTE), encompassing both deep vein thrombosis (DVT) and pulmonary embolism (PE), is a leading cause of morbidity and mortality worldwide. Methods: GARFIELD-VTE is a prospective, non-interventional observational study of real-world treatment practices. We aimed to capture the 36-month clinical outcomes of 10,679 patients with objectively confirmed VTE enrolled between May 2014 and January 2017 from 415 sites in 28 countries. Findings: A total of 6582 (61.6 %) patients had DVT alone, 4097 (38.4 %) had PE ± DVT. At baseline, 98.1 % of patients received anticoagulation (AC) with or without other modalities of therapy. The proportion of patients on AC therapy decreased over time: 87.6 % at 3 months, 73.0 % at 6 months, 54.2 % at 12 months and 42.0 % at 36 months. At 12-months follow-up, the incidences (95 % confidence interval [CI]) of all-cause mortality, recurrent VTE and major bleeding were 6.5 (7.0–8.1), 5.4 (4.9–5.9) and 2.7 (2.4–3.0) per 100 person-years, respectively. At 36-months, these decreased to 4.4 (4.2–4.7), 3.5 (3.2–2.7) and 1.4 (1.3–1.6) per 100 person-years, respectively. Over 36-months, the rate of all-cause mortality and major bleeds were highest in patients treated with parenteral therapy (PAR) versus oral anti-coagulants (OAC) and no OAC, and the rate of recurrent VTE was highest in patients on no OAC versus those on PAR and OAC. The most frequent cause of death after 36-month follow-up was cancer (n = 565, 48.6 %), followed by cardiac (n = 94, 8.1 %), and VTE (n = 38, 3.2 %). Most recurrent VTE events were DVT alone (n = 564, 63.3 %), with the remainder PE, (n = 236, 27.3 %), or PE in combination with DVT (n = 63, 7.3 %). Interpretation: GARFIELD-VTE provides a global perspective of anticoagulation patterns and highlights the accumulation of events within the first 12 months after diagnosis. These findings may help identify treatment gaps for subsequent interventions to improve patient outcomes in this patient population.",
keywords = "Anticoagulation, Deep vein thrombosis, Pulmonary embolism, Registry, Venous thromboembolism",
author = "Turpie, {Alexander G. G.} and Farjat, {Alfredo E.} and Sylvia Haas and {GARFIELD-VTE investigators} and Walter Ageno and Weitz, {Jeffrey I.} and Goldhaber, {Samuel Z.} and Shinya Goto and Pantep Angchaisuksiri and Gloria Kayani and Lopes, {Renato D.} and Chern-En Chiang and Harry Gibbs and Eric Tse and Peter Verhamme and {ten Cate}, Hugo and Juan Muntaner and Sebastian Schellong and Henri Bounameaux and Paolo Prandoni and Kakkar, {Ajay K.} and Ab Loualidi and Abdurrahim Colak and Abraham Bezuidenhout and Abu Abdool-Carrim and Addala Azeddine and Adriaan Beyers and Adriaan Dees and Ahmed Mohamed and Ahmet Aksoy and Akihiko Abiko and Akinori Watanabe and Alan Krichell and Fernandez, {Alberto Alfredo} and Alberto Tosetto and Alexey Khotuntsov and Alisha Oropallo and Alison Slocombe and Allan Kelly and Amanda Clark and Amr Gad and Amy Arouni and Andor Schmidt and Andrea Berni and Kleiban, {Andres Javier} and Andrew Machowski and Andrey Kazakov and Angel Galvez and Ann Lockman and Anna Falanga and Anoop Chauhan and Antoni Riera-Mestre and Antonino Mazzone and Armando D'Angelo and Artur Herdy and Atsushi Kato and Salem, {Ayman Abd Elhamid Ebrahim Mahmoud} and Azlan Husin and Barbara Erdelyi and Barry Jacobson and Beatrice Amann-Vesti and Bektas Battaloglu and Benedicte Wilson and Benilde Cosmi and Francois, {Bergmann Jean} and Berremeli Toufek and Beverley Hunt and Bhavesh Natha and Bisher Mustafa and Kho, {Bonnie Chi Shan} and Boulon Carine and Brian Zidel and Brisot Dominique and Brousse Christophe and Bruno Trimarco and Canhua Luo and Cuneo, {Carlos Alberto} and Diaz, {Carlos Jerjes Sanchez} and Carsten Schwencke and Cas Cader and Celal Yavuz and Zaidman, {Cesar Javier} and Charles Lunn and Chau-Chung Wu and Toh, {Cheng Hock} and Chevrier Elisa and Chien-Hsun Hsia and Chien-Lung Huang and Kwok, {Chi-Hang Kevin} and Chih-Cheng Wu and Chi-Hung Huang and Chris Ward and Christian Opitz and Christina Jeanneret-Gris and Ha, {Chung Yin} and Chun-Yao Huang and Bidi, {Claude Luyeye} and Clifford Smith and Cornelia Brauer and Corrado Lodigiani and Couturaud Francis and Cynthia Wu and Daniel Staub and Daniel Theodoro and Daniela Poli and Acevedo, {David - Riesco} and David Adler and David Jimenez and David Keeling and David Scott and Davide Imberti and Desmond Creagh and Desmurs-Clavel Helene and Dirk Hagemann and {le Roux}, Dirk and Dirk Skowasch and Dmitry Belenky and Dmitry Dorokhov and Dmitry Petrov and Dmitry Zateyshchikov and Domenico Prisco and Dorthe M{\o}ller and Dusan Kucera and Esheiba, {Ehab M.} and Elizaveta Panchenko and Elkouri Dominique and Emre Dogan and Emre Kubat and Diaz, {Enrique Diaz} and Tse, {Eric Wai Choi} and Erik Yeo and Erman Hashas and Ernst Grochenig and Eros Tiraferri and Erwin Blessing and Mich{\`e}le, {Escande Orthlieb} and Esther Usandizaga and Ettore Porreca and Fabian Ferroni and Falvo Nicolas and Ayala-Paredes, {F. lix} and Firas Koura and Fitjerald Henry and Franco Cosmi and Frans Erdkamp and Gadel Kamalov and Garcia-Bragado Dalmau and Garrigues Damien and Garry Klein and Gaurand Shah and Geert Hollanders and Geno Merli and Georg Plassmann and George Platt and Germain Poirier and German Sokurenko and Ghassan Haddad and Gholam Ali and Giancarlo Agnelli and Gan, {Gin Gin} and Grace Kaye-Eddie and {le Gal}, Gregoire and Gregory Allen and Esper{\'o}n, {Guillermo Antonio Llamas} and Guillot Jean-Paul and Hagen Gerofke and Hallah Elali and Hana Burianova and Hans-Juergen Ohler and Haofu Wang and Harald Darius and Gogia, {Harinder S.} and Harry Striekwold and Hatice Hasanoglu and Hatice Turker and Hendrik Franow and {de Raedt}, Herbert and Herman Schroe and ElDin, {Hesham Salah} and Hesham Zidan and Hiroaki Nakamura and Kim, {Ho Young} and Holger Lawall and Hong Zhu and Hongyan Tian and Ho-Young Yhim and Hwang, {Hun Gyu} and Hyeok Shim and Igor Kim and Igor Libov and Igor Sonkin and Igor Suchkov and Ik-Chan Song and Ilker Kiris and Ilya Staroverov and Irene Looi and {de la Azuela Tenorio}, {Isabel M.} and Ismail Savas and Ivan Gordeev and Ivo Podpera and Lee, {Jae Hoon} and Jameela Sathar and James Welker and Jan Beyer-Westendorf and Jan Kvasnicka and Jan Vanwelden and JangYong Kim and Jaromira Svobodova and Jaspal Gujral and Javier Marino and Galvar, {Javier Tristan} and Jeannine Kassis and Jen-Yuan Kuo and Jhih-Yuan Shih and JiHyun Kwon and Joh, {Jin Hyun} and Park, {Jin Hyun} and Kim, {Jin Seok} and Jinghua Yang and Jiri Krupicka and Jiri Lastuvka and Jiri Pumprla and Jiri Vesely and Souto, {Joan Carlos} and Correa, {Jo{\~a}o Ant{\^o}nio} and Johan Duchateau and Fletcher, {John Perry} and {del Toro}, Jorge and Paez, {Jorge Guillermo Chavez} and Nielsen, {J. rn} and Filho, {Jose Dalmo Araujo} and Jose Saraiva and Peromingo, {Jose Antonio Diaz} and Lara, {Jose Gomez} and Fedele, {Jose Luis} and Surinach, {Jose Maria} and Joseph Chacko and Muntaner, {Juan Antonio} and Benitez, {Juan Carlos {\'A}lvarez} and Abril, {Juan Moreno Hoyos} and Julian Humphrey and Julio Bono and Junji Kanda and Juree Boondumrongsagoon and Yiu, {Kai Hang} and Kanchana Chansung and Karin Boomars and Kate Burbury and Katsuhiro Kondo and Kemal Karaarslan and Kensuke Takeuchi and Knut Kroeger and Konstantin Zrazhevskiy and Kosc{\'a}l Svatopluk and Kou-Gi Shyu and Kristel Vandenbosch and Kuan-Cheng Chang and Kuan-Ming Chiu and Kubina Jean-Manuel and Wern, {Kwan Jing} and Kwo-Chang Ueng and Lalita Norasetthada and Laure Binet and Chew, {Lee Ping} and Lei Zhang and Cristina, {Leone Maria} and Lidwine Tick and Schiavi, {Lilia Beatriz} and Wong, {Lily Lee Lee} and Lohana Borges and Louis Botha and Luc Capiau and Luc Timmermans and L{\'o}pez, {Luciano Eduardo} and Luigi Ria and Blasco, {Luis Manuel Hernandez} and Guzman, {Luis Alberto} and Cervera, {Luis Flota} and Mahe Isabelle and Bosch, {Manuel Monreal} and {de los Rios Ibarra}, Manuel and Fernandez, {Manuel N. {\~n}ez} and Marc Carrier and Barrionuevo, {Marcelo Raul} and Gamba, {Marco Antonio Alcocer} and Marco Cattaneo and Marco Moia and Margaret Bowers and Mariam Chetanachan and Berli, {Mario Alberto} and Mark Fixley and Markus Faghih and Markus Stuecker and Marlin Schul and Martin Banyai and Martin Koretzky and Martin Myriam and Gaffney, {Mary Elizabeth} and Masao Hirano and Masashi Kanemoto and Mashio Nakamura and Mersel Tahar and Messas Emmanuel and Michael Kovacs and Michael Leahy and Michael Levy and Michael Munch and Michael Olsen and {de Pauw}, Michel and Michel Gustin and {van Betsbrugge}, Michiel and Mikhail Boyarkin and Miroslav Homza and Modise Koto and Mohamed Abdool-Gaffar and Nagib, {Mohamed Ayman Fakhry} and Mohamed el-Dessoki and Mohamed Khan and Monniaty Mohamed and Kim, {Moo Hyun} and Moon-Hee Lee and Mosaad Soliman and Ahmed, {Mostafa Shawky} and {el Bary}, {Mostafa Soliman Abd} and Moustafa, {Moustafa A.} and Muhammad Hameed and Muhip Kanko and Mujibur Majumder and Nadezhda Zubareva and Nicola Mumoli and Abdullah, {Nik Azim Nik} and Nisa Makruasi and Nishen Paruk and Nonglak Kanitsap and Norberto Duda and Nordiana Nordin and Ole Nyvad and Olga Barbarash and Orcun Gurbuz and Vilamajo, {Oscar Gomez} and Flores, {Oscar Nandayapa} and Ozcan Gur and Oztekin Oto and Marchena, {Pablo Javier} and Patrick Carroll and Pavel Lang and Peter MacCallum and {von Bilderling}, {Peter Baron} and Peter Blombery and Petr Jansky and Peuch Bernadette and {de Vleeschauwer}, Philippe and Philippe Hainaut and Ferrini, {Piera Maria} and Piriyaporn Iamsai and Ponchaux Christian and Pongtep Viboonjuntra and Ponlapat Rojnuckarin and Prahlad Ho and Pramook Mutirangura and Rachel Wells and Rafael Martinez and Miranda, {Raimundo Tirado} and Ralf Kroening and Rapule Ratsela and Reyes, {Raquel Lopez} and {de Leon}, {Raul Franco Diaz} and Wong, {Raymond Siu Ming} and Raz Alikhan and Reinhold Jerwan-Keim and Remedios Otero and Renate Murena-Schmidt and Reto Canevascini and Richard Ferkl and Richard White and {van Herreweghe}, Rika and Rita Santoro and Robert Klamroth and Robert Mendes and Robert Prosecky and Roberto Cappelli and Rudolf Spacek and Rupesh Singh and Sam Griffin and Na, {Sang Hoon} and Sanjeev Chunilal and Saskia Middeldorp and Satoshi Nakazawa and Toh, {See Guan} and Seinturier Christophe and Selim Isbir and Selma Raymundo and Ting, {Seng Kiat} and Serge Motte and Aktogu, {Serir Ozkan} and Servaas Donders and Cha, {Seung Ick} and Seung-Hyun Nam and Sevestre-Pietri Marie-Antoinette and Shaun Maasdorp and Shenghua Sun and Shenming Wang and Essameldin, {Sherif Mohamed} and Sholkamy, {Sherif Mohamed} and Shintaro Kuki and Shuichi Yoshida and Shunzo Matsuoka and Simon McRae and Simon Watt and Siriwimon Patanasing and Siwe-Nana Jean-L{\'e}opold and Somchai Wongkhantee and Soo-Mee Bang and Sophie Testa and Stanislav Zemek and Steffen Behrens and Stephan Dominique and Stuart Mellor and Singh, {Suaran Singh Gurcharan} and Sudip Datta and Sunee Chayangsu and Susan Solymoss and Tamara Everington and Abdel-Azim, {Tarek Ahmed Adel} and Tawatchai Suwanban and Taylan Adademir and Terence Hart and Terriat B{\'e}atrice and Thifhelimbilu Luvhengo and Thomas Horacek and Thomas Zeller and Tim Boussy and Tim Reynolds and Tina Biss and Ting-Hsing Chao and Casabella, {Tomas Smith} and Tomoya Onodera and Tontanai Numbenjapon and Victor Gerdes and Vladimir Cech and Vladimir Krasavin and Vladimir Tolstikhin and Bax, {W. A.} and Malek, {Wagih Fawzy Abdel} and Ho, {Wai Khoon} and Walter Pharr and Weihong Jiang and Wei-Hsiang Lin and Weihua Zhang and Wei-Kung Tseng and Wen-Ter Lai and {de Backer}, Wilfried and Wilhelm Haverkamp and Winston Yoshida and Wolfgang Korte and Choi, {Won Il} and Yang-Ki Kim and Yasuhiro Tanabe and Yasushi Ohnuma and Yeung-Chul Mun and Yohan Balthazar and Yong Park and Yoshisato Shibata and Yuriy Burov and Yuriy Subbotin and Zdenek Coufal and Zhenwen Yang and Zhicheng Jing and Zhongqi Yang",
note = "Funding Information: GARFIELD-VTE is a non-interventional, prospective, multicentre, observational registry designed to capture real-world outcomes of patients with acute VTE. The study design for GARFIELD-VTE has been described previously [9] and the registry was funded by an unrestricted research grant from Bayer AG. Men and women ≥18 years of age with an objectively confirmed diagnosis of VTE within 30 days of entry into the registry were eligible for inclusion. Patients with recurrent VTE must have completed treatment for the previous VTE episode. Those with superficial vein thrombosis or participating in an interventional study that dictated treatments, or for whom long-term follow up was not possible were excluded. Patients were managed according to local practices; no specific treatments, tests, or procedures were mandated by the protocol. Decisions to initiate, continue or change treatment were solely at the discretion of the treating physicians and their patients. Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2023",
month = feb,
day = "1",
doi = "10.1016/j.thromres.2022.11.016",
language = "English",
volume = "222",
pages = "31--39",
journal = "Thrombosis research",
issn = "0049-3848",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - 36-month clinical outcomes of patients with venous thromboembolism

T2 - GARFIELD-VTE

AU - Turpie, Alexander G. G.

AU - Farjat, Alfredo E.

AU - Haas, Sylvia

AU - GARFIELD-VTE investigators

AU - Ageno, Walter

AU - Weitz, Jeffrey I.

AU - Goldhaber, Samuel Z.

AU - Goto, Shinya

AU - Angchaisuksiri, Pantep

AU - Kayani, Gloria

AU - Lopes, Renato D.

AU - Chiang, Chern-En

AU - Gibbs, Harry

AU - Tse, Eric

AU - Verhamme, Peter

AU - ten Cate, Hugo

AU - Muntaner, Juan

AU - Schellong, Sebastian

AU - Bounameaux, Henri

AU - Prandoni, Paolo

AU - Kakkar, Ajay K.

AU - Loualidi, Ab

AU - Colak, Abdurrahim

AU - Bezuidenhout, Abraham

AU - Abdool-Carrim, Abu

AU - Azeddine, Addala

AU - Beyers, Adriaan

AU - Dees, Adriaan

AU - Mohamed, Ahmed

AU - Aksoy, Ahmet

AU - Abiko, Akihiko

AU - Watanabe, Akinori

AU - Krichell, Alan

AU - Fernandez, Alberto Alfredo

AU - Tosetto, Alberto

AU - Khotuntsov, Alexey

AU - Oropallo, Alisha

AU - Slocombe, Alison

AU - Kelly, Allan

AU - Clark, Amanda

AU - Gad, Amr

AU - Arouni, Amy

AU - Schmidt, Andor

AU - Berni, Andrea

AU - Kleiban, Andres Javier

AU - Machowski, Andrew

AU - Kazakov, Andrey

AU - Galvez, Angel

AU - Lockman, Ann

AU - Falanga, Anna

AU - Chauhan, Anoop

AU - Riera-Mestre, Antoni

AU - Mazzone, Antonino

AU - D'Angelo, Armando

AU - Herdy, Artur

AU - Kato, Atsushi

AU - Salem, Ayman Abd Elhamid Ebrahim Mahmoud

AU - Husin, Azlan

AU - Erdelyi, Barbara

AU - Jacobson, Barry

AU - Amann-Vesti, Beatrice

AU - Battaloglu, Bektas

AU - Wilson, Benedicte

AU - Cosmi, Benilde

AU - Francois, Bergmann Jean

AU - Toufek, Berremeli

AU - Hunt, Beverley

AU - Natha, Bhavesh

AU - Mustafa, Bisher

AU - Kho, Bonnie Chi Shan

AU - Carine, Boulon

AU - Zidel, Brian

AU - Dominique, Brisot

AU - Christophe, Brousse

AU - Trimarco, Bruno

AU - Luo, Canhua

AU - Cuneo, Carlos Alberto

AU - Diaz, Carlos Jerjes Sanchez

AU - Schwencke, Carsten

AU - Cader, Cas

AU - Yavuz, Celal

AU - Zaidman, Cesar Javier

AU - Lunn, Charles

AU - Wu, Chau-Chung

AU - Toh, Cheng Hock

AU - Elisa, Chevrier

AU - Hsia, Chien-Hsun

AU - Huang, Chien-Lung

AU - Kwok, Chi-Hang Kevin

AU - Wu, Chih-Cheng

AU - Huang, Chi-Hung

AU - Ward, Chris

AU - Opitz, Christian

AU - Jeanneret-Gris, Christina

AU - Ha, Chung Yin

AU - Huang, Chun-Yao

AU - Bidi, Claude Luyeye

AU - Smith, Clifford

AU - Brauer, Cornelia

AU - Lodigiani, Corrado

AU - Francis, Couturaud

AU - Wu, Cynthia

AU - Staub, Daniel

AU - Theodoro, Daniel

AU - Poli, Daniela

AU - Acevedo, David - Riesco

AU - Adler, David

AU - Jimenez, David

AU - Keeling, David

AU - Scott, David

AU - Imberti, Davide

AU - Creagh, Desmond

AU - Helene, Desmurs-Clavel

AU - Hagemann, Dirk

AU - le Roux, Dirk

AU - Skowasch, Dirk

AU - Belenky, Dmitry

AU - Dorokhov, Dmitry

AU - Petrov, Dmitry

AU - Zateyshchikov, Dmitry

AU - Prisco, Domenico

AU - Møller, Dorthe

AU - Kucera, Dusan

AU - Esheiba, Ehab M.

AU - Panchenko, Elizaveta

AU - Dominique, Elkouri

AU - Dogan, Emre

AU - Kubat, Emre

AU - Diaz, Enrique Diaz

AU - Tse, Eric Wai Choi

AU - Yeo, Erik

AU - Hashas, Erman

AU - Grochenig, Ernst

AU - Tiraferri, Eros

AU - Blessing, Erwin

AU - Michèle, Escande Orthlieb

AU - Usandizaga, Esther

AU - Porreca, Ettore

AU - Ferroni, Fabian

AU - Nicolas, Falvo

AU - Ayala-Paredes, F. lix

AU - Koura, Firas

AU - Henry, Fitjerald

AU - Cosmi, Franco

AU - Erdkamp, Frans

AU - Kamalov, Gadel

AU - Dalmau, Garcia-Bragado

AU - Damien, Garrigues

AU - Klein, Garry

AU - Shah, Gaurand

AU - Hollanders, Geert

AU - Merli, Geno

AU - Plassmann, Georg

AU - Platt, George

AU - Poirier, Germain

AU - Sokurenko, German

AU - Haddad, Ghassan

AU - Ali, Gholam

AU - Agnelli, Giancarlo

AU - Gan, Gin Gin

AU - Kaye-Eddie, Grace

AU - le Gal, Gregoire

AU - Allen, Gregory

AU - Esperón, Guillermo Antonio Llamas

AU - Jean-Paul, Guillot

AU - Gerofke, Hagen

AU - Elali, Hallah

AU - Burianova, Hana

AU - Ohler, Hans-Juergen

AU - Wang, Haofu

AU - Darius, Harald

AU - Gogia, Harinder S.

AU - Striekwold, Harry

AU - Hasanoglu, Hatice

AU - Turker, Hatice

AU - Franow, Hendrik

AU - de Raedt, Herbert

AU - Schroe, Herman

AU - ElDin, Hesham Salah

AU - Zidan, Hesham

AU - Nakamura, Hiroaki

AU - Kim, Ho Young

AU - Lawall, Holger

AU - Zhu, Hong

AU - Tian, Hongyan

AU - Yhim, Ho-Young

AU - Hwang, Hun Gyu

AU - Shim, Hyeok

AU - Kim, Igor

AU - Libov, Igor

AU - Sonkin, Igor

AU - Suchkov, Igor

AU - Song, Ik-Chan

AU - Kiris, Ilker

AU - Staroverov, Ilya

AU - Looi, Irene

AU - de la Azuela Tenorio, Isabel M.

AU - Savas, Ismail

AU - Gordeev, Ivan

AU - Podpera, Ivo

AU - Lee, Jae Hoon

AU - Sathar, Jameela

AU - Welker, James

AU - Beyer-Westendorf, Jan

AU - Kvasnicka, Jan

AU - Vanwelden, Jan

AU - Kim, JangYong

AU - Svobodova, Jaromira

AU - Gujral, Jaspal

AU - Marino, Javier

AU - Galvar, Javier Tristan

AU - Kassis, Jeannine

AU - Kuo, Jen-Yuan

AU - Shih, Jhih-Yuan

AU - Kwon, JiHyun

AU - Joh, Jin Hyun

AU - Park, Jin Hyun

AU - Kim, Jin Seok

AU - Yang, Jinghua

AU - Krupicka, Jiri

AU - Lastuvka, Jiri

AU - Pumprla, Jiri

AU - Vesely, Jiri

AU - Souto, Joan Carlos

AU - Correa, João Antônio

AU - Duchateau, Johan

AU - Fletcher, John Perry

AU - del Toro, Jorge

AU - Paez, Jorge Guillermo Chavez

AU - Nielsen, J. rn

AU - Filho, Jose Dalmo Araujo

AU - Saraiva, Jose

AU - Peromingo, Jose Antonio Diaz

AU - Lara, Jose Gomez

AU - Fedele, Jose Luis

AU - Surinach, Jose Maria

AU - Chacko, Joseph

AU - Muntaner, Juan Antonio

AU - Benitez, Juan Carlos Álvarez

AU - Abril, Juan Moreno Hoyos

AU - Humphrey, Julian

AU - Bono, Julio

AU - Kanda, Junji

AU - Boondumrongsagoon, Juree

AU - Yiu, Kai Hang

AU - Chansung, Kanchana

AU - Boomars, Karin

AU - Burbury, Kate

AU - Kondo, Katsuhiro

AU - Karaarslan, Kemal

AU - Takeuchi, Kensuke

AU - Kroeger, Knut

AU - Zrazhevskiy, Konstantin

AU - Svatopluk, Koscál

AU - Shyu, Kou-Gi

AU - Vandenbosch, Kristel

AU - Chang, Kuan-Cheng

AU - Chiu, Kuan-Ming

AU - Jean-Manuel, Kubina

AU - Wern, Kwan Jing

AU - Ueng, Kwo-Chang

AU - Norasetthada, Lalita

AU - Binet, Laure

AU - Chew, Lee Ping

AU - Zhang, Lei

AU - Cristina, Leone Maria

AU - Tick, Lidwine

AU - Schiavi, Lilia Beatriz

AU - Wong, Lily Lee Lee

AU - Borges, Lohana

AU - Botha, Louis

AU - Capiau, Luc

AU - Timmermans, Luc

AU - López, Luciano Eduardo

AU - Ria, Luigi

AU - Blasco, Luis Manuel Hernandez

AU - Guzman, Luis Alberto

AU - Cervera, Luis Flota

AU - Isabelle, Mahe

AU - Bosch, Manuel Monreal

AU - de los Rios Ibarra, Manuel

AU - Fernandez, Manuel N. ñez

AU - Carrier, Marc

AU - Barrionuevo, Marcelo Raul

AU - Gamba, Marco Antonio Alcocer

AU - Cattaneo, Marco

AU - Moia, Marco

AU - Bowers, Margaret

AU - Chetanachan, Mariam

AU - Berli, Mario Alberto

AU - Fixley, Mark

AU - Faghih, Markus

AU - Stuecker, Markus

AU - Schul, Marlin

AU - Banyai, Martin

AU - Koretzky, Martin

AU - Myriam, Martin

AU - Gaffney, Mary Elizabeth

AU - Hirano, Masao

AU - Kanemoto, Masashi

AU - Nakamura, Mashio

AU - Tahar, Mersel

AU - Emmanuel, Messas

AU - Kovacs, Michael

AU - Leahy, Michael

AU - Levy, Michael

AU - Munch, Michael

AU - Olsen, Michael

AU - de Pauw, Michel

AU - Gustin, Michel

AU - van Betsbrugge, Michiel

AU - Boyarkin, Mikhail

AU - Homza, Miroslav

AU - Koto, Modise

AU - Abdool-Gaffar, Mohamed

AU - Nagib, Mohamed Ayman Fakhry

AU - el-Dessoki, Mohamed

AU - Khan, Mohamed

AU - Mohamed, Monniaty

AU - Kim, Moo Hyun

AU - Lee, Moon-Hee

AU - Soliman, Mosaad

AU - Ahmed, Mostafa Shawky

AU - el Bary, Mostafa Soliman Abd

AU - Moustafa, Moustafa A.

AU - Hameed, Muhammad

AU - Kanko, Muhip

AU - Majumder, Mujibur

AU - Zubareva, Nadezhda

AU - Mumoli, Nicola

AU - Abdullah, Nik Azim Nik

AU - Makruasi, Nisa

AU - Paruk, Nishen

AU - Kanitsap, Nonglak

AU - Duda, Norberto

AU - Nordin, Nordiana

AU - Nyvad, Ole

AU - Barbarash, Olga

AU - Gurbuz, Orcun

AU - Vilamajo, Oscar Gomez

AU - Flores, Oscar Nandayapa

AU - Gur, Ozcan

AU - Oto, Oztekin

AU - Marchena, Pablo Javier

AU - Carroll, Patrick

AU - Lang, Pavel

AU - MacCallum, Peter

AU - von Bilderling, Peter Baron

AU - Blombery, Peter

AU - Jansky, Petr

AU - Bernadette, Peuch

AU - de Vleeschauwer, Philippe

AU - Hainaut, Philippe

AU - Ferrini, Piera Maria

AU - Iamsai, Piriyaporn

AU - Christian, Ponchaux

AU - Viboonjuntra, Pongtep

AU - Rojnuckarin, Ponlapat

AU - Ho, Prahlad

AU - Mutirangura, Pramook

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AU - Martinez, Rafael

AU - Miranda, Raimundo Tirado

AU - Kroening, Ralf

AU - Ratsela, Rapule

AU - Reyes, Raquel Lopez

AU - de Leon, Raul Franco Diaz

AU - Wong, Raymond Siu Ming

AU - Alikhan, Raz

AU - Jerwan-Keim, Reinhold

AU - Otero, Remedios

AU - Murena-Schmidt, Renate

AU - Canevascini, Reto

AU - Ferkl, Richard

AU - White, Richard

AU - van Herreweghe, Rika

AU - Santoro, Rita

AU - Klamroth, Robert

AU - Mendes, Robert

AU - Prosecky, Robert

AU - Cappelli, Roberto

AU - Spacek, Rudolf

AU - Singh, Rupesh

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AU - Na, Sang Hoon

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AU - Nakazawa, Satoshi

AU - Toh, See Guan

AU - Christophe, Seinturier

AU - Isbir, Selim

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AU - Ting, Seng Kiat

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AU - Aktogu, Serir Ozkan

AU - Donders, Servaas

AU - Cha, Seung Ick

AU - Nam, Seung-Hyun

AU - Marie-Antoinette, Sevestre-Pietri

AU - Maasdorp, Shaun

AU - Sun, Shenghua

AU - Wang, Shenming

AU - Essameldin, Sherif Mohamed

AU - Sholkamy, Sherif Mohamed

AU - Kuki, Shintaro

AU - Yoshida, Shuichi

AU - Matsuoka, Shunzo

AU - McRae, Simon

AU - Watt, Simon

AU - Patanasing, Siriwimon

AU - Jean-Léopold, Siwe-Nana

AU - Wongkhantee, Somchai

AU - Bang, Soo-Mee

AU - Testa, Sophie

AU - Zemek, Stanislav

AU - Behrens, Steffen

AU - Dominique, Stephan

AU - Mellor, Stuart

AU - Singh, Suaran Singh Gurcharan

AU - Datta, Sudip

AU - Chayangsu, Sunee

AU - Solymoss, Susan

AU - Everington, Tamara

AU - Abdel-Azim, Tarek Ahmed Adel

AU - Suwanban, Tawatchai

AU - Adademir, Taylan

AU - Hart, Terence

AU - Béatrice, Terriat

AU - Luvhengo, Thifhelimbilu

AU - Horacek, Thomas

AU - Zeller, Thomas

AU - Boussy, Tim

AU - Reynolds, Tim

AU - Biss, Tina

AU - Chao, Ting-Hsing

AU - Casabella, Tomas Smith

AU - Onodera, Tomoya

AU - Numbenjapon, Tontanai

AU - Gerdes, Victor

AU - Cech, Vladimir

AU - Krasavin, Vladimir

AU - Tolstikhin, Vladimir

AU - Bax, W. A.

AU - Malek, Wagih Fawzy Abdel

AU - Ho, Wai Khoon

AU - Pharr, Walter

AU - Jiang, Weihong

AU - Lin, Wei-Hsiang

AU - Zhang, Weihua

AU - Tseng, Wei-Kung

AU - Lai, Wen-Ter

AU - de Backer, Wilfried

AU - Haverkamp, Wilhelm

AU - Yoshida, Winston

AU - Korte, Wolfgang

AU - Choi, Won Il

AU - Kim, Yang-Ki

AU - Tanabe, Yasuhiro

AU - Ohnuma, Yasushi

AU - Mun, Yeung-Chul

AU - Balthazar, Yohan

AU - Park, Yong

AU - Shibata, Yoshisato

AU - Burov, Yuriy

AU - Subbotin, Yuriy

AU - Coufal, Zdenek

AU - Yang, Zhenwen

AU - Jing, Zhicheng

AU - Yang, Zhongqi

N1 - Funding Information: GARFIELD-VTE is a non-interventional, prospective, multicentre, observational registry designed to capture real-world outcomes of patients with acute VTE. The study design for GARFIELD-VTE has been described previously [9] and the registry was funded by an unrestricted research grant from Bayer AG. Men and women ≥18 years of age with an objectively confirmed diagnosis of VTE within 30 days of entry into the registry were eligible for inclusion. Patients with recurrent VTE must have completed treatment for the previous VTE episode. Those with superficial vein thrombosis or participating in an interventional study that dictated treatments, or for whom long-term follow up was not possible were excluded. Patients were managed according to local practices; no specific treatments, tests, or procedures were mandated by the protocol. Decisions to initiate, continue or change treatment were solely at the discretion of the treating physicians and their patients. Publisher Copyright: © 2022 The Authors

PY - 2023/2/1

Y1 - 2023/2/1

N2 - Background: Venous thromboembolism (VTE), encompassing both deep vein thrombosis (DVT) and pulmonary embolism (PE), is a leading cause of morbidity and mortality worldwide. Methods: GARFIELD-VTE is a prospective, non-interventional observational study of real-world treatment practices. We aimed to capture the 36-month clinical outcomes of 10,679 patients with objectively confirmed VTE enrolled between May 2014 and January 2017 from 415 sites in 28 countries. Findings: A total of 6582 (61.6 %) patients had DVT alone, 4097 (38.4 %) had PE ± DVT. At baseline, 98.1 % of patients received anticoagulation (AC) with or without other modalities of therapy. The proportion of patients on AC therapy decreased over time: 87.6 % at 3 months, 73.0 % at 6 months, 54.2 % at 12 months and 42.0 % at 36 months. At 12-months follow-up, the incidences (95 % confidence interval [CI]) of all-cause mortality, recurrent VTE and major bleeding were 6.5 (7.0–8.1), 5.4 (4.9–5.9) and 2.7 (2.4–3.0) per 100 person-years, respectively. At 36-months, these decreased to 4.4 (4.2–4.7), 3.5 (3.2–2.7) and 1.4 (1.3–1.6) per 100 person-years, respectively. Over 36-months, the rate of all-cause mortality and major bleeds were highest in patients treated with parenteral therapy (PAR) versus oral anti-coagulants (OAC) and no OAC, and the rate of recurrent VTE was highest in patients on no OAC versus those on PAR and OAC. The most frequent cause of death after 36-month follow-up was cancer (n = 565, 48.6 %), followed by cardiac (n = 94, 8.1 %), and VTE (n = 38, 3.2 %). Most recurrent VTE events were DVT alone (n = 564, 63.3 %), with the remainder PE, (n = 236, 27.3 %), or PE in combination with DVT (n = 63, 7.3 %). Interpretation: GARFIELD-VTE provides a global perspective of anticoagulation patterns and highlights the accumulation of events within the first 12 months after diagnosis. These findings may help identify treatment gaps for subsequent interventions to improve patient outcomes in this patient population.

AB - Background: Venous thromboembolism (VTE), encompassing both deep vein thrombosis (DVT) and pulmonary embolism (PE), is a leading cause of morbidity and mortality worldwide. Methods: GARFIELD-VTE is a prospective, non-interventional observational study of real-world treatment practices. We aimed to capture the 36-month clinical outcomes of 10,679 patients with objectively confirmed VTE enrolled between May 2014 and January 2017 from 415 sites in 28 countries. Findings: A total of 6582 (61.6 %) patients had DVT alone, 4097 (38.4 %) had PE ± DVT. At baseline, 98.1 % of patients received anticoagulation (AC) with or without other modalities of therapy. The proportion of patients on AC therapy decreased over time: 87.6 % at 3 months, 73.0 % at 6 months, 54.2 % at 12 months and 42.0 % at 36 months. At 12-months follow-up, the incidences (95 % confidence interval [CI]) of all-cause mortality, recurrent VTE and major bleeding were 6.5 (7.0–8.1), 5.4 (4.9–5.9) and 2.7 (2.4–3.0) per 100 person-years, respectively. At 36-months, these decreased to 4.4 (4.2–4.7), 3.5 (3.2–2.7) and 1.4 (1.3–1.6) per 100 person-years, respectively. Over 36-months, the rate of all-cause mortality and major bleeds were highest in patients treated with parenteral therapy (PAR) versus oral anti-coagulants (OAC) and no OAC, and the rate of recurrent VTE was highest in patients on no OAC versus those on PAR and OAC. The most frequent cause of death after 36-month follow-up was cancer (n = 565, 48.6 %), followed by cardiac (n = 94, 8.1 %), and VTE (n = 38, 3.2 %). Most recurrent VTE events were DVT alone (n = 564, 63.3 %), with the remainder PE, (n = 236, 27.3 %), or PE in combination with DVT (n = 63, 7.3 %). Interpretation: GARFIELD-VTE provides a global perspective of anticoagulation patterns and highlights the accumulation of events within the first 12 months after diagnosis. These findings may help identify treatment gaps for subsequent interventions to improve patient outcomes in this patient population.

KW - Anticoagulation

KW - Deep vein thrombosis

KW - Pulmonary embolism

KW - Registry

KW - Venous thromboembolism

UR - http://www.scopus.com/inward/record.url?scp=85144538710&partnerID=8YFLogxK

U2 - 10.1016/j.thromres.2022.11.016

DO - 10.1016/j.thromres.2022.11.016

M3 - Article

C2 - 36565677

VL - 222

SP - 31

EP - 39

JO - Thrombosis research

JF - Thrombosis research

SN - 0049-3848

ER -

ID: 29722913