Bacterial meningitis. In 2002, we completed a study on the life-saving effect of adjunctive dexamethasone therapy in bacterial meningitis. Subsequently, we identified defining factors in the prognosis of this devastating disease in the largest cohort study to date. We translated research results to clinical practice in papers on the management of meningitis. In 2013, results were publsiehd on a RCT on hypothermia in bacterial meningitis. MeninGene is a nationwide project on genetic traits that may support the susceptibility to severe forms of bacterial meningitis. We have a strong collaboration with the Wellcome Trust Sanger Centre.

Encephalitis. Recently, we completed the PACEM study. In this prospective cohort study we aim to systematically determine the causes of meningitis and encephalitis in children and adults with suspected bacterial meningitis, and describe clinical and laboratory findings in these patients.

Neurosarcoidosis. Neurosarcoidosis a condition of unknown cause featuring granulomas in various tissues, involving the central nervous system (brain and spinal cord). In a prospective cohort study we evaluate clinical characteristics, genetic background, treatment and outcome of this disease. We aim to create a center of excellence for neurosarcoidosis within the the upcoming 2 years.

Infections after stroke. Stroke is a leading cause of death worldwide. Fever after stroke is a strong predictor of a poor outcome. Infections occur in up to 40% of patients with stroke and have also been associated with poor outcomes. In 2015, results were published of the Preventive Antibiotics in Stroke Study (PASS) on preventive use of the antibiotic ceftriaxone iin patients with acute stroke. Currently, we are particpating in the PRECIOUS project.

Septic encephalopathy. Experimental findings and neuropathological observations suggest that activation of microglia is pivotal for mediation of the behavioural effects of systemic infections. The microglial response is usually regulated tightly, but defensive features could turn neurotoxic once microglial cells escape from cholinergic inhibition. In a prospective autopsy study and animals models we evaluate the role of microglial activation in sepsis associated encephalopathy.

Inflammatory diseases of peripheral nerves and muscles. The immune mediated neuropathies (e.g. GBS, CIDP, MMN) and myopathies (e.g. dermatomysositis, IBM) and critical illness neuropathy and myopathy are the specific diseases of interest. Clinical trials, cohort studies and studies investigating immunological and genomic characterization of nerve and muscle inflammation are performed. From these studies we try to arrive at clinically relevant biomarkers of disease activity and predictors of response.
Effective start/end date01/12/2010 → …

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