We have made progress in a number of areas relating to the interaction of HIV-1 with the host and which likely modulate viral transmission and disease progression. Notably we identified the main component in human milk that binds to the DC-SIGN C-type lectin expressed on dendritic cells and which can block HIV-1 capture and trasnfer to CD4 lymphocytes. This is a glycoprotein called bile salt stimulated lipase and which has multiple isoforms with variant capacities to inhibit transfer. we are currently in the process of analyzing how the variant forms correlate with protection against HIV-1 infection. we have also shown that the interaction of HIV-1 with the DC-SIGN molecule can be influenced by alterations in the gp120 envelope sequence thereby potentially aiding viral selection during transmission or disease progression. We also identified a phenomenon whereby virus associated with neutralizing antibodies can bind DC-SIGN then remain infectious for CD4 lymphocytes, thereby describing a new mechanism of immune evasion with implications for HIV-1 vaccine design and development. We have initiated a project looking at HIV-1 compartmentalization in Th1 versus Th2 subtypes and will
move this project into the field in Ghana where we will study HIV-1 infected individuasl co-infected with parasitic infections.

Theme: Infection and Immunity

This research group participates in CINIMA
Effective start/end date01/01/2006 → …

ID: 180619