Bioartificial Liver (BAL)

In our research group we aim to develop a BAL, consisting of a bioreactor loaded with liver cells that mimics a functional liver. As such it can be used in the clinic for liver support of liver failure patients and in the laboratory for drug safety tests and disease models. We have developed a BAL (AMC-BAL) based on a human cell line that differentiates to a high degree. A laboratory model of the BAL has shown efficacy in an animal model of liver failure.

Our current research lines:

Development of a downscaled BAL as a human liver model for studies of liver disease and drug toxicity

Setting up a clinical trial with an upscaled GMP-compliant BAL

Improve current culture methods for liver cells using technologies derived from BAL culturing
Effective start/end date01/05/2013 → …

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