Psychosis, Variation, Phase, Profile

Needs, circum¬stances and characteristics of people with psychotic disorders differ substantially. In research we need to capture this variation in phase and profile.
We focus on patients with recent onset psychotic disorders and their variation - in therapeutic and subjective response on antipsychotic treatment, - co-morbidity and - cognitive and social functioning.
These variations are thought to be partly related to differences in dopaminergic neurotransmission.
Increased striatal dopamine synthesis and dopamine reactivity to stress is related to dysregulated salience attribution and thereby psychotic symptoms. Modulation of dopaminergic neurotransmission by antipsychotic medication and illicit drugs affects symptoms and wellbeing.

The three main strategic research objectives of the Early Psychosis Department are:
1. Finding brain and behavioral characteristics of specific disturbances in early psychotic disorders.
a. Identify the relationship between neural activity and specific disturbances in psychotic disorders.
b. Identify genetic and environmental factors associated with variation in early psychotic disorders.
c. Identify biological markers in patients with psychotic disorders.
2. Define the developmental trajectories around onset of psychotic disorders to determine when and how to intervene.
3. Develop better interventions directed at the diverse needs, circum¬stances and characteristics of people with early psychotic disorders.
Effective start/end date01/08/2007 → …

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