The Esophagus Center of the AMC is the largest referral clinic for non-malignant esophageal disorders in the Netherlands. We combine an special clinical expertise with a large number of trials and studies focussed on finding underlying pathophysiology, assessment of new diagnostic techniques and improved treatments. Three diseases are central: gastroesophageal reflux disease (GERD), eosinophilic esophagitis (EoE) and achalasia. Collaborations with interventional endoscopists (Prof P Fockens), surgeons (Dr M Schijven en Dr M van Berge Henegouwen), pathologists (Dr J Verheij), pediatricians (Prof M Benninga) and basic scientists (Prof W de Jonge and dr R van den Wijngaard) are essential for the great results of our group.