The esophageal research team conducts imaging studies to improve the detection of arly neoplasia in the upper GI tract. Examples of techniques that are investigated are: high resolution endoscopy, chromoscopy, autofluorescence endoscopy, narrow band imaging, confocal endomicroscopy, endocytoscopy, and spectroscopy techniques. Recently tested new imaging techniques include OFDI, a/LCI, and fluorescence spectroscopy.

In addition, the group has a strong focus on the endoscopic treatment of early neoplasia using endoscopic resection and endoscopic ablation techniques as well as in organizing training programs in this field ( and ). The group has an experimental research line (led by prof B.L.A.M. Weusten) that conducts animal experiments of new endoscopic resection and ablation tools.

The group also conducts basic research on biomarkers in Barrett’s esophagus; epithelial differentiation, morphogenesis and pathogenesis in Barrett’s esophagus; gene therapy and dendritic cell therapy for esophageal cancer; and proteomics in Barrett’s esophagus. This part is led by Dr. Sheila Krishnadth, gastroenterologist at the same department.

The team currently consists of four physicians/endoscopists, ten clinical research fellows, one post-docs, four basic science research fellows, five research nurses, and 2 physician assistants. The group has extensive experience with clinical trials and is trained according to GCP standards.
The esophageal research team coordinates several international multi-center studies all relating to endoscopic detection and treatment of early neoplasia in the upper gastrointestinal tract.

The esophageal research team coordinates the Amsterdam Barrett´s Registration Project. Barrett’s patients undergoing endoscopic surveillance in 6 non-university hospitals in the Amsterdam region participate in a prospective Barrett’s surveillance program in which dedicated Barrett’s endoscopy programs are coordinated and supported by research nurses for prospective collection of endoscopic data and patient material.

IDATE: Initiative for Detection And Treatment of Early neoplasia in the upper gastrointestinal tract. Dr Bergman has initiated this project which follows up on a two-year training program for 6 centers in the Netherlands and Belgium. This has created a platform for high quality patient care, mutual research and guideline development.

ReBus: progREsion of Barrett's esophagUS: a large tissue bank project that incorporates clinical data and tissue samples of 1,000 patients treated for early Barrett's neoplasia; 3,500 Barrett's surveillance patients in the Amsterdam region; 1,500 proscpectively followed Barrett's patients in the aforementioned Barett's Registration Project; and 750 Barrett's patients with low-grade dysplasia.
Effective start/end date01/01/2006 → …

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