Research interests

Perform fundamental and clinical research to develop therapeutics that can reduce vessel wall degradation and thus decrease the growth (rate) and/or rupture risk of aortic aneurysms.

specialisation

Marfan Syndrome, aortic aneurysm development

Research output

  1. Resveratrol Inhibits Aortic Root Dilatation in the Fbn1C1039G/+ Marfan Mouse Model

    Research output: Contribution to journal › Article › Academic › peer-review

  2. Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling

    Research output: Contribution to journal › Article › Academic › peer-review

  3. Beneficial Outcome of Losartan Therapy Depends on Type of FBN1 Mutation in Marfan Syndrome

    Research output: Contribution to journal › Article › Academic › peer-review

  4. Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial

    Research output: Contribution to journal › Article › Academic › peer-review

  5. Immunosuppressive drug azathioprine reduces aneurysm progression through inhibition of Rac1 and c-Jun-terminal-N-kinase in endothelial cells

    Research output: Contribution to journal › Article › Academic › peer-review

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Projects

  1. de Vries C.J.M.: Nuclear Receptor Nur77 in Vascular Biology and Metabolism

    Project: Research

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ID: 51581