Research interests

-How do glycosphingolipids play their pathological role in obesity/type 2 diabetes

-How does pharmacological manipulation of synthesis and breakdown of glycosphingolipids impact on obesity/type 2 diabetes

-In Gaucher Disease interest regards discovery of biomarkers and the observed insulin resistance.

-Given the fact that both Gaucher disease and obesity/type 2 diabetes clearly show involvement of macrophages in their pathology a more general focus on macrophage biology exists as well.   

specialisation

Type 2 diabetes, obesity, macrophage biology, Gaucher disease and biomarkers

Research output

  1. Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation

    Research output: Contribution to journalArticleAcademicpeer-review

  2. The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1

    Research output: Contribution to journalArticleAcademicpeer-review

  3. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution

    Research output: Contribution to journalArticleAcademicpeer-review

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