Research interests

Lyme borreliosis and ticks

The overall aim of the research is to contribute to the understanding of the molecular mechanisms important for both tick feeding and Borrelia transmission and to identify possible new targets for the development of an anti-tick vaccine. Ixodes ticks are not ordinary needle and syringes that simply inject Borrelia spirochetes into the host’s skin, given that Borrelia utilizes tick proteins to successfully move from the arthropod vector to the mammalian host and vice versa. Thus, the way forward in developing an efficient and long lasting vaccine in order to prevent Borrelia transmission, would be to target both Borrelia and tick antigens leading to a synergistic and optimized clearance of Borrelia at the tick bite site. Future studies will determine whether immunizations with the recombinant tick proteins also impair transmission of Borrelia and other pathogens from the tick to the host. Moreover, tick saliva is a potential source for novel pharmacological agents that could be useful for clinical practice.
 

The role of the intestinal microbiome in sepsis

Recent breakthroughs in our understanding of the role of the gut microbiome in both health and diseases are of considerable importance for the field of immunology, infectious diseases and intensive care medicine. In addition to its local contribution in the host defense against infections, it has become clear that the intestine also plays a role in systemic immune responses. Release of gut nutrients and microbial components termed MAMPs continuously primes and support distant systemic immune cells. Manipulating the intestine microbiome by gut flora replacement or the use of specific bacterial components and/or metabolites is an interesting new treatment modality in order to restore gut homeostasis and possibly prevent septic complications and MODS in critically ill patients.Our work focuses on key aspects of the role of the intestinal microbiome in the immune response against pathogens and the importance of intestinal homeostasis for critically ill patients. 

specialisation

Infectious diseases, immunology and coagulation.

Research output

  1. Structure-function of anticoagulant TIX-5, the inhibitor of factor Xa-mediated FV activation

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Major bleeding during oral anticoagulant therapy associated with factor V activation by factor Xa

    Research output: Contribution to journalArticleAcademicpeer-review

  3. The role of Mannose Binding Lectin in the immune response against Borrelia burgdorferi sensu lato

    Research output: Contribution to journalArticleAcademicpeer-review

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