Research interests

My research focuses on the identification of signaling pathways induced by C-type lectins on dendritic cells and how these signaling pathways lead to pathogen-specific T cell polarization, neutrophil activation as well as anti-viral responses, which could be targeted therapeutically to either enhance immunity or deter aberrant immunity.
 

specialisation

Molecular biology, signal transduction, innate immunology

Research output

  1. Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1 beta via a noncanonical caspase-8 inflammasome

    Research output: Contribution to journal › Article › Academic › peer-review

  2. C-type lectin receptors in the control of T helper cell differentiation

    Research output: Contribution to journal › Review article › Academic › peer-review

  3. Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antifungal immunity

    Research output: Contribution to journal › Article › Academic › peer-review

  4. Measles Virus Suppresses RIG-I-like Receptor Activation in Dendritic Cells via DC-SIGN-Mediated Inhibition of PP1 Phosphatases

    Research output: Contribution to journal › Article › Academic › peer-review

  5. HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3

    Research output: Contribution to journal › Article › Academic › peer-review

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Projects

  1. Gringhuis S.I.: C-type lectin signaling in infection and immunity

    Project: Research

  2. Geijtenbeek T.B.H.: C-type lectins in infection and immunity

    Project: Research

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ID: 44661