Research interests

 

Our focus on research is on premature atherosclerosis.

Fifty percent of all individuals, whom die of cardiovascular disease, are older than 80 years of age. This means, that cardiovascular disease is a disease of older age. Whenever young individuals develop cardiovascular disease, for instance a myocardial infarction at the age of 40 years, this is very unusual. This is called premature atherosclerosis. Likely, this person will have accelerated atherosclerotic disease. Sometimes this occurs in several family member of one family, suggesting a genetic predisposition for accelerate atherosclerotic disease.

Our main focus is on unravelling the underlying mechanisms responsible for accelerate atherosclerosis from an epidemiological, genetic and basic science point of view. Secondly, we try to estimate the risk family members have for accelerated atherosclerosis, since due to their young age the standard risk models cannot be used.

For that matter we have developed a premature atherosclerosis family outpatient clinic, in which we counsel patients and family members on cause, treatment and risk of cardiovascular disease.

 

 

 

specialisation

vascular medicin with special attention in premature atherosclerose and miRNA research

Research output

  1. Sudden cardiac death in families with premature cardiovascular disease

    Research output: Contribution to journalArticleAcademicpeer-review

  2. A Crucial Role for Diet in the Relationship between Gut Microbiota and Cardiometabolic Disease

    Research output: Contribution to journalReview articleAcademicpeer-review

  3. A pooled-analysis of age and sex based coronary artery calcium scores percentiles

    Research output: Contribution to journalArticleAcademicpeer-review

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