Research interests

Rogier Sanders specialises in designing novel antiviral vaccines and antibodies. One of his major contributions was the development of stabilised HIV-1 envelope protein vaccines, which are now in clinical phase testing. In addition, this approach allowed for the first high-resolution structures of HIV-1 envelope protein trimers, which was hailed by Science as a scientific breakthrough in 2013 and fuelled structure-based HIV-1 vaccine design around the globe. Importantly, Rogier Sanders innovative proline-based stabilisation method was later used in the development of vaccines against RSV (respiratory syncytial virus), SARS-CoV, MERS-CoV, and recently SARS-CoV-2, the virus that causes COVID-19; indeed, Pfizer/BioNTech, Moderna, Novavax, and Janssen/Johnson & Johnson have all incorporated this method into their development of SARS-CoV-2 vaccines, and to date several hundreds of millions of people have received these vaccines, saving countless lives. His contribution to the rapid development of SARS-CoV-2 vaccines based on his seminal work with HIV-1 was acknowledged by Dr Anthony Fauci (Director of the National Institute of Allergy and Infectious Diseases and Chief Medical Advisor to the President of the United States) during a press conference at the White House in April 2021. Sanders provided a brief historical perspective in a mini-review.

Two additional applications of stabilised glycoprotein antigens are for sorting antigen-specific B cells and generating monoclonal antibodies. For example, an HIV-1 antibody co-discovered by Prof. Sanders is now in clinical testing for the prevention and treatment of HIV-1 infection. Moreover, Sanders co-discovered potently neutralizing SARS-CoV-2 antibodies. The general application is now used by countless labs around the world for a wide range of viruses.

 

specialisation

Virology, in particular Experimental Vaccinology

Research output

  1. Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

    Research output: Contribution to journalArticleAcademicpeer-review

  2. HIV-1 neutralizing antibodies induced by native-like envelope trimers

    Research output: Contribution to journalArticleAcademicpeer-review

  3. An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability

    Research output: Contribution to journalArticleAcademicpeer-review

  4. HIV: A stamp on the envelope

    Research output: Contribution to journalEditorialAcademicpeer-review

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