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  1. 2020

  2. Overexpression of the constitutive androstane receptor and shaken 3D-culturing increase biotransformation and oxidative phosphorylation and sensitivity to mitochondrial amiodarone toxicity of HepaRG cells

    van der Mark, V. A., Adam, A. A. A., Chang, J-C., Oude Elferink, R. P., Chamuleau, R. A. F. M. & Hoekstra, R., 15 Jul 2020, In: Toxicology and applied pharmacology. 399, 115055.

    Research output: Contribution to journal › Article › Academic › peer-review

  3. End-stage liver failure: filling the treatment gap at the intensive care unit

    Chamuleau, R. A. F. M. & Hoekstra, R., 1 Jun 2020, In: Journal of Artificial Organs. 23, 2, p. 113-123 11 p.

    Research output: Contribution to journal › Review article › Academic › peer-review

  4. Genome-wide expression profiling reveals increased stability and mitochondrial energy metabolism of the human liver cell line HepaRG-CAR

    Adam, A. A. A., Jongejan, A., Moerland, P. D., van der Mark, V. A., Oude Elferink, R. P., Chamuleau, R. A. F. M. & Hoekstra, R., 1 Jun 2020, In: Cytotechnology. 72, 3, p. 377-395 19 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  5. 2019

  6. Overexpression of carbamoyl-phosphate synthase 1 significantly improves ureagenesis of human liver HepaRG cells only when cultured under shaking conditions

    Adam, A. A. A., van der Mark, V. A., Ruiter, J. P. N., Wanders, R. J. A., Oude Elferink, R. P. J., Chamuleau, R. A. F. M. & Hoekstra, R., 2019, In: Mitochondrion. 47, p. 298-308

    Research output: Contribution to journal › Article › Academic › peer-review

  7. 2018

  8. AMC-Bio-Artificial Liver culturing enhances mitochondrial biogenesis in human liver cell lines: The role of oxygen, medium perfusion and 3D configuration

    Adam, A. A. A., van Wenum, M., van der Mark, V. A., Jongejan, A., Moerland, P. D., Houtkooper, R. H., Wanders, R. J. A., Oude Elferink, R. P., Chamuleau, R. A. F. M. & Hoekstra, R., 2018, In: Mitochondrion. 39, p. 30-42

    Research output: Contribution to journal › Article › Academic › peer-review

  9. A practice-changing culture method relying on shaking substantially increases mitochondrial energy metabolism and functionality of human liver cell lines

    Adam, A. A. A., van der Mark, V. A., Donkers, J. M., Wildenberg, M. E., Oude Elferink, R. P. J., Chamuleau, R. A. F. M. & Hoekstra, R., 2018, In: PLoS ONE. 13, 4, e0193664.

    Research output: Contribution to journal › Article › Academic › peer-review

  10. HepaRG-Progenitor Cell Derived Hepatocytes Cultured in Bioartificial Livers Are Protected from Healthy- and Acute Liver Failure-Plasma Induced Toxicity

    van Wenum, M., Treskes, P., Adam, A. A. A., van der Mark, V. A., Jongejan, A., Moerland, P. D., van Gulik, T. M., Oude Elferink, R. P. J., Chamuleau, R. A. F. M. & Hoekstra, R., 2018, In: Cellular physiology and biochemistry. 48, 5, p. 2189-2204

    Research output: Contribution to journal › Article › Academic › peer-review

  11. Oxygen drives hepatocyte differentiation and phenotype stability in liver cell lines

    van Wenum, M., Adam, A. A. A., van der Mark, V. A., Chang, J-C., Wildenberg, M. E., Hendriks, E. J., Jongejan, A., Moerland, P. D., van Gulik, T. M., Oude Elferink, R. P., Chamuleau, R. A. F. M. & Hoekstra, R., 2018, In: Journal of cell communication and signaling. 12, 3, p. 575 588 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  12. 2017

  13. Advances in methods for characterization of hepatic urea cycle enzymatic activity in HepaRG cells using UPLC-MS/MS

    Moedas, M. F., Adam, A. A. A., Farelo, M. A., IJlst, L., Chamuleau, R. A. F. M., Hoekstra, R., Wanders, R. J. A. & Silva, M. F. B., 2017, In: Analytical biochemistry. 535, p. 47-55

    Research output: Contribution to journal › Article › Academic › peer-review

  14. Scaling-up of a HepaRG progenitor cell based bioartificial liver: optimization for clinical application and transport

    van Wenum, M., Treskes, P., Tang, C-Y., Coppens, E. J., Jansen, K., Hendriks, E. J., Camus, S., van Gulik, T. M., Chamuleau, R. A. F. M. & Hoekstra, R., 2017, In: BIOFABRICATION. 9, 3, p. 035001

    Research output: Contribution to journal › Article › Academic › peer-review

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