Research interests

During my PhD, I studied basal ganglia development in a mouse model of Parkinson's disease. During my neurosurgical training, I specialised in deep brain stimulation (DBS) of the basal ganglia. My research interests focus on improving the outcome of DBS surgery in established indications (such as Parkinson's disease and essential tremor) and the application of experimental DBS in new indications. Since 2009, I act(ed) as a co-investigator on clinical trials studying 1. subthalamic nucleus versus globus pallidus DBS in Parkinson's disease (co-promotor of Vincent Odekerken), 2. nucleus accumbens DBS in obsessive-compulsive disorder, 3. internal capsule DBS in depression, 4. internal capsule DBS in anorexia nervosa, 5. general anesthesia versus local anesthesie in DBS for Parkinson's disease (co-promotor of Rozemarije Holewijn). I initiated several research projects to improve the radiological and neurophysiological targeting of DBS surgery (co-promotor of Maarten Bot and Erik Bolier). Since 2017, I act as principal investigator of the RECONNECT trial, studying the effects of DBS of the central thalamus in patients with disorders of consciousness (co-promotor of Hisse Arnts). For this trial, I created a multidisciplinary national research alliance. 

Research output

  1. Awakening after a sleeping pill: Restoring functional brain networks after severe brain injury

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Deep brain stimulation for Parkinson's disease: defining the optimal location within the subthalamic nucleus

    Research output: Contribution to journalArticleAcademicpeer-review

  3. The Dilemma of Hydrocephalus in Prolonged Disorders of Consciousness

    Research output: Contribution to journalReview articleAcademicpeer-review

  4. Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons

    Research output: Contribution to journalArticleAcademicpeer-review

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