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- 2011
Distinct functional domains contribute to degradation of the low density lipoprotein receptor (LDLR) by the E3 ubiquitin ligase inducible Degrader of the LDLR (IDOL)
Sorrentino, V., Scheer, L., Santos, A., Reits, E., Bleijlevens, B. & Zelcer, N., 2011, In: Journal of biological chemistry. 286, 34, p. 30190-30199Research output: Contribution to journal › Article › Academic › peer-review
Targeted disruption of the Idol gene alters cellular regulation of the LDLR by sterols and LXR agonists
Scotti, E., Hong, C., Yoshinaga, Y., Tu, Y., Hu, Y., Zelcer, N., Boyadjian, R., de Jong, P. J., Young, S. G., Fong, L. G. & Tontonoz, P., 2011, In: Molecular and cellular biology. 31, 9, p. 1885-1893Research output: Contribution to journal › Article › Academic › peer-review
The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans
Weissglas-Volkov, D., Calkin, A. C., Tusie-Luna, T., Sinsheimer, J. S., Zelcer, N., Riba, L., Tino, A. M. V., Ordoñez-Sánchez, M. L., Cruz-Bautista, I., Aguilar-Salinas, C. A., Tontonoz, P. & Pajukanta, P., 2011, In: Journal of clinical investigation. 121, 8, p. 3062-3071Research output: Contribution to journal › Article › Academic › peer-review
- 2010
The E3 Ubiquitin Ligase IDOL Induces the Degradation of the Low Density Lipoprotein Receptor Family Members VLDLR and ApoER2
Hong, C., Duit, S., Jalonen, P., Out, R., Scheer, L., Sorrentino, V., Boyadjian, R., Rodenburg, K. C. W., Foley, E., Korhonen, L., Lindholm, D., Nimpf, J., van Berkel, T. J. C., Tontonoz, P. & Zelcer, N., 2010, In: Journal of biological chemistry. 285, 26, p. 19720-19726Research output: Contribution to journal › Article › Academic › peer-review
- 2009
Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR
A-Gonzalez, N., Bensinger, S. J., Hong, C., Beceiro, S., Bradley, M. N., Zelcer, N., Deniz, J., Ramirez, C., Díaz, M., Gallardo, G., de Galarreta, C. R., Salazar, J., Lopez, F., Edwards, P., Parks, J., Andujar, M., Tontonoz, P. & Castrillo, A., 2009, In: Immunity. 31, 2, p. 245-258Research output: Contribution to journal › Article › Academic › peer-review
LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor
Zelcer, N., Hong, C., Boyadjian, R. & Tontonoz, P., 2009, In: Science. 325, 5936, p. 100-104Research output: Contribution to journal › Article › Academic › peer-review
- 2008
ApoE promotes the proteolytic degradation of Abeta
Jiang, Q., Lee, C. Y. D., Mandrekar, S., Wilkinson, B., Cramer, P., Zelcer, N., Mann, K., Lamb, B., Willson, T. M., Collins, J. L., Richardson, J. C., Smith, J. D., Comery, T. A., Riddell, D., Holtzman, D. M., Tontonoz, P. & Landreth, G. E., 2008, In: Neuron. 58, 5, p. 681-693Research output: Contribution to journal › Article › Academic › peer-review
LXR signaling couples sterol metabolism to proliferation in the acquired immune response
Bensinger, S. J., Bradley, M. N., Joseph, S. B., Zelcer, N., Janssen, E. M., Hausner, M. A., Shih, R., Parks, J. S., Edwards, P. A., Jamieson, B. D. & Tontonoz, P., 2008, In: Cell. 134, 1, p. 97-111Research output: Contribution to journal › Article › Academic › peer-review
- 2007
Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors
Zelcer, N., Khanlou, N., Clare, R., Jiang, Q., Reed-Geaghan, E. G., Landreth, G. E., Vinters, H. V. & Tontonoz, P., 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 25, p. 10601-10606Research output: Contribution to journal › Article › Academic › peer-review
Multidrug resistance proteins 2 and 3 provide alternative routes for hepatic excretion of morphine-glucuronides
van de Wetering, K., Zelcer, N., Kuil, A., Feddema, W., Hillebrand, M., Vlaming, M. L. H., Schinkel, A. H., Beijnen, J. H. & Borst, P., 2007, In: Molecular pharmacology. 72, 2, p. 387-394Research output: Contribution to journal › Article › Academic › peer-review
ID: 107375