Research interests

Biomaterial-associated infections and novel antimicrobial strategies

 

Infections of biomedical devices, or “biomaterials” (catheters, prosthetic heart valves, implants), are a major and increasing problem in modern medicine, especially in view of the increase in antibiotic resistance. We have discovered that bacteria do not only colonize the medical device by biofilm-formation, but also persist in surrounding tissue, due to disturbed local immunity. Bacterial, biomaterial, and host-responses involved in the pathogenesis are subject of studies, in order to find novel approaches for treatment and prevention.


Previously involved in the Dutch NANTICO (Non-adherent ANTImicrobial Coatings) consortium, focused on the development of different antimicrobial coating strategies to prevent biomaterial-associated infections, and in the European FP7 project Biofilm Alliance (BALI), where we developed novel Synthetic Antimicrobial and Anti-biofilm Peptides.


Currently involved in the STW project CRANIOSAFE, aiming to develop innovative antimicrobial materials for skull reconstructions, and the NEWPOL project SuperActiv, developing supramolecular biomaterials with antimicrobial and regenerative activity.

 

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