Research interests

-How do glycosphingolipids play their pathological role in obesity/type 2 diabetes

-How does pharmacological manipulation of synthesis and breakdown of glycosphingolipids impact on obesity/type 2 diabetes

-In Gaucher Disease interest regards discovery of biomarkers and the observed insulin resistance.

-Given the fact that both Gaucher disease and obesity/type 2 diabetes clearly show involvement of macrophages in their pathology a more general focus on macrophage biology exists as well.   

specialisation

Type 2 diabetes, obesity, macrophage biology, Gaucher disease and biomarkers

Research output

  1. HEPES-buffering of bicarbonate-containing culture medium perturbs lysosomal glucocerebrosidase activity

    Research output: Contribution to journal › Article › Academic › peer-review

  2. The unique phenotype of lipid-laden macrophages

    Research output: Contribution to journal › Review article › Academic › peer-review

  3. Gcase and limp2 abnormalities in the liver of niemann pick type c mice

    Research output: Contribution to journal › Article › Academic › peer-review

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Projects

  1. Aerts J.M.F.G.: Glycosphingolipids in health and disease

    Project: Research

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ID: 96433