Research interests

Gene Therapy.
The focus of the research is to develop Adeno Associated liver directed gene therapy to treat inherited unconjugated hyperbilirubinemia. This research is partly funded by the Dutch Najjar foundation. Succeslfull application of AAV in this patients will also enable us to use this strategy to treat other inherited liver diseases.

specialisation

Gene therapy

Research output

  1. Long-term effects of biliverdin reductase a deficiency in ugt1−/− mice: impact on redox status and metabolism

    Research output: Contribution to journal › Article › Academic › peer-review

  2. Reduced spontaneous itch in mouse models of cholestasis

    Research output: Contribution to journal › Article › Academic › peer-review

  3. Low efficacy of recombinant SV40 in Ugt1a1-/- mice with severe inherited hyperbilirubinemia

    Research output: Contribution to journal › Article › Academic › peer-review

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Projects

  1. Bosma P.J.: Novel therapies for liver disease

    Project: Research

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ID: 89201