Research interests

Although influenza alone can result in severe pneumonia, the high mortality rates are mostly associated with secondary bacterial complications. These bacterial superinfections often require hospitalization and even admission to the Intensive Care Unit. However, little is known about the mechanisms that underly the exaggerated  inflammatory response associated with complicated pneumonia. Both viral and bacterial infection in the lower respiratory tract will cause lung injury, resulting in the release of damage-associated molecular patterns (DAMPs). These DAMPs provide a danger signal by binding to the specific pattern-recognition receptors (PRRs). We currently explore the expression profiles of these PRRs and the release of DAMPs in a mouse-model for secondary bacterial complications as well as material collected from ICU patients with suspected influenza-related illness.


Viral airway infections and inflammation

Research output

  1. Nebulized Heparin in Burn Patients with Inhalation Trauma-Safety and Feasibility

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Respiratory Viruses in Invasively Ventilated Critically Ill Patients-A Prospective Multicenter Observational Study

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Treatment with broadly neutralizing influenza antibodies reduces severity of secondary pneumococcal pneumonia in mice

    Research output: Contribution to journalArticleAcademicpeer-review

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ID: 94985