Research interests

To study human T cell differentiation and development, a Hu-SCID mouse model was set up. RAG2-/-/gc-/- double KO mice, which have no T, B and NK cells, are used as immunodeficient mice, in which human fetal hematopoietic stem cells or tissues (from fetal thymus, liver, spleen, bone, cord blood or mobilized peripheral blood cells), are transplanted. Stem cells or precursor cells can be transduced with a gene of interest. Subsequently, the fate of the injected cells can be followed in the HIS-mouse (human immune system mouse) and the role of the gene can be studied.
Since substantial numbers of human cells are present this HIS-mouse can be used to test vaccines and drugs.
 

specialisation

Development and improvement of humanized (HIS) mice as in vivo model for man.

Research output

  1. Early effects of htlv-1 infection on the activation, exhaustion, and differentiation of t-cells in humanized nsg mice

    Research output: Contribution to journal › Article › Academic › peer-review

  2. Diverse HIV-1 escape pathways from broadly neutralizing antibody PGDM1400 in humanized mice

    Research output: Contribution to journal › Article › Academic › peer-review

  3. Short Communication: Protective Efficacy of Broadly Neutralizing Antibody PGDM1400 Against HIV-1 Challenge in Humanized Mice

    Research output: Contribution to journal › Article › Academic › peer-review

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