Research interests

Our research is focused on the role of DNA mutagenic processes in the adaptive immune system and in B-cell malignancies. I have a background in molecular biology and immunology, and my research includes DNA repair, immunoglobulin gene diversification mechanisms and signaling in B cells and B-cell malignancies. My laboratory addresses fundamental questions on DNA damage and repair in B cells and lymphomas, and performs translational research on novel drugs and therapeutic targets for (childhood) leukemia and multiple myeloma. My laboratory is part of the Lymphoma and Myeloma Center Amsterdam (LYMMCARE) consortium.

specialisation

Molecular biology of immunoglobulin gene recombinations

Research output

  1. The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling

    Research output: Contribution to journalArticleAcademicpeer-review

  2. NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Mechanism and regulation of class switch recombination

    Research output: Contribution to journalReview articleAcademicpeer-review

  5. APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination

    Research output: Contribution to journalArticleAcademicpeer-review

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