Research interests

Switching genes on or off and keeping them in that state involves packaging of the genome by wrapping it around histone proteins. Histones cary different chemical modifications that affect the packaging of DNA by epigenetic mechanisms. The Van Leeuwen lab, located at the Netherlands Cancer Institute, studies mechanisms and principles of epigenetic regulation using innovative proteomic, genetic, and genomics approaches.

Our current work focuses on

- developing novel barcode technologies to decode the fundamental principles of epigenetic regulation in yeast and human cells

- understanding the role of epigenetics in the immune system, with special interest in the histone methyltransferase DOT1L in differentiation and function in B and T cells in mouse models,

More information about our research, lab, and publications, see:

www.medischebiologie.nl/van-leeuwen-group/

www.nki.nl/divisions/gene-regulation/van-leeuwen-fr-group/

 

specialisation

Epigenetics

Research output

  1. Dynamic epistasis analysis reveals how chromatin remodeling regulates transcriptional bursting

    Research output: Contribution to journal › Article › Academic › peer-review

  2. DOT1L regulates chromatin reorganization and gene expression during sperm differentiation

    Research output: Contribution to journal › Article › Academic › peer-review

  3. DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability

    Research output: Contribution to journal › Article › Academic › peer-review

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