Research interests

The research of my group is devoted to the vascular system, with a special interest in the biomechanics and mechanobiology of the vascular wall and the regulation of organ perfusion. Our scientific objectives range from unraveling of basic mechanisms to understanding pathogenesis and consequences of notably acute ischemic stroke, vascular cognitive impairment, hypertension, atherosclerosis, coronary artery disease and intracranial aneurysms. We use a wide variety of approaches. These include clinical imaging modalities (in collaboration with Radiology), in vivo approaches such as rodent intracranial window, hypertension and flow restriction models, perfused arteries and arterioles of human and animal origin in organoid culture, cell-based experimental models, molecular techniques, and mathematical modeling and simulation. My group aims to combine biophysical and functional experiments with analysis of molecular parameters. Our philosophy is to perform integrative science and utilize a systems approach in order to correlate molecular mechanisms with structure and function of blood vessels and vascular networks in health and disease.

specialisation

Biophysics

Research output

  1. Extravasation of Microspheres in a Rat Model of Silent Brain Infarcts

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Cerebral oxygen metabolism in adults with sickle cell disease

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Paravascular spaces at the brain surface: Low resistance pathways for cerebrospinal fluid flow

    Research output: Contribution to journalArticleAcademicpeer-review

  4. Endothelial basement membrane laminin 511 is essential for shear stress response

    Research output: Contribution to journalArticleAcademicpeer-review

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