Research interests

Since my employment as PhD student at the University of Utrecht my research focused on obsessive compulsive (spectrum) disorders. OCD was approached from diverse perspectives by means of different methodological tools. One perspective covers OCD from clinical viewpoint and inquires its nosological status. Is OCD a discrete psychiatric disorder or does it represent different clinical subtypes? Another part encompasses randomized clinical trials and aimed to contribute to the pharmacological management of OCD. Is switching drugs in case of non-response to treatment a useful strategy for patients with OCD? Can we identify clinical characteristics that predict a favorable treatment response with pharmacotherapy? Is addition of an atypical antipsychotic to a serotonergic reuptake inhibitor beneficial for treatment-resistant OCD patients? Another perspective addresses OCD from etiological perspective and investigates the role of neurotransmitters in OCD. What is the effect of the combination of an atypical antipsychotic to a serotonergic reuptake inhibitor on dopamine and serotonin levels in different (rat) brain areas? Can we find in vivo evidence for the involvement of the dopamine system in OCD through imaging-studies? Is there an association between specific genotypes of dopamine or serotonergic genes and OCD? Currently, my research focuses on the applicability of deep brain stimulation in OCD and psychiatric disorders.

specialisation

Psychiatry

Research output

  1. Long-term deep brain stimulation of the ventral anterior limb of the internal capsule for treatment-resistant depression

    Research output: Contribution to journalArticleAcademicpeer-review

  2. Attachment in OCD: A meta-analysis

    Research output: Contribution to journalArticleAcademicpeer-review

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