Research interests

Our research is centered around the cellular and pathophysiological functions of P4 ATPases, lipid flippases that are implicated in the biogenesis of transport vesicles. Genome-wide association studies predict a role for various P4 ATPases as predisposing factors in complex diseases, including atherosclerosis, rheumatoid arthritis, type 2 diabetes and Alzheimer’s disease. It is our goal to delineate the role of P4 ATPases in aforementioned diseases.

specialisation

Biochemistry, cell biology, phospholipid transport, Hepatobiliary transport, cholestasis

Research output

  1. The phospholipid flippase ATP8B1 is required for lysosomal fusion in macrophages

    Research output: Contribution to journal › Article › Academic › peer-review

  2. ATP8B1 Deficiency Results in Elevated Mitochondrial Phosphatidylethanolamine Levels and Increased Mitochondrial Oxidative Phosphorylation in Human Hepatoma Cells

    Research output: Contribution to journal › Article › Academic › peer-review

  3. Amino acid metabolism, transport and signalling in the liver revisited

    Research output: Contribution to journal › Review article › Academic › peer-review

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Projects

  1. Oude Elferink R.P.J.: Hepatic transport processes and Bioartificial Liver Support

    Project: Research

  2. van de Graaf K.F.J. (Stan): metabolite dynamics and liver-centered organ crosstalk

    Project: Research

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ID: 77698