Research interests

Cardiovascular aspects of Surgery and Critical Illness.

The Laboratory of Translational Physiology at the Academic Medical Center is dedicated to research into cardiovascular aspects of perioperative medicine (e.g. surgery and intensive care medicine) with an emphasis on organ function, (micro)circulation and cellular and mitochondrial oxygenation. Its research is strongly translational where (pahto)physiological and therapeutic concepts were developed in the laboratory are applied to clinical practice. Research topics include sepsis, acute kidney injury, myocardial depression, ischemia reperfussion, hemorheology, resuscitation and fluid therapy related to surgery and critical care medicine. Basic science interests related to these subjects are focused on renal and heart failure, red blood cell (pahto)physiology, cellular oxygen metabolism, nitric oxide and oxygen radical species and mitochondiral oxygenation and bioenergetics. To carry out these investigations and conduct translational research from bench to bedside we also carry out Research and development on clinical and experimental medical technology which are directed at optical spectroscopy of tissue and mitochondrial oxygenation and clinical microcirculation imaging


Cardiovascular aspects of surgery and intensive care medicine

Research output

  1. CHRISTMAS 2012: RESEARCH Why Rudolph's nose is red: observational study

    Research output: Contribution to journalEditorialAcademicpeer-review

  2. The case for 0.9% NaCl: is the undefendable, defensible?

    Research output: Contribution to journalReview articleAcademicpeer-review

  3. Why and when the microcirculation becomes disassociated from the macrocirculation

    Research output: Contribution to journalComment/Letter to the editorAcademic

  4. Renal Hemodynamics in AKI: In Search of New Treatment Targets

    Research output: Contribution to journalArticleAcademicpeer-review

  5. Cerebral venous system and anatomical predisposition to high-altitude headache

    Research output: Contribution to journalArticleAcademicpeer-review

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