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Cardiovascular aspects of Surgery and Critical Illness.

The Laboratory of Translational Physiology at the Academic Medical Center is dedicated to research into cardiovascular aspects of perioperative medicine (e.g. surgery and intensive care medicine) with an emphasis on organ function, (micro)circulation and cellular and mitochondrial oxygenation. Its research is strongly translational where (pahto)physiological and therapeutic concepts were developed in the laboratory are applied to clinical practice. Research topics include sepsis, acute kidney injury, myocardial depression, ischemia reperfussion, hemorheology, resuscitation and fluid therapy related to surgery and critical care medicine. Basic science interests related to these subjects are focused on renal and heart failure, red blood cell (pahto)physiology, cellular oxygen metabolism, nitric oxide and oxygen radical species and mitochondiral oxygenation and bioenergetics. To carry out these investigations and conduct translational research from bench to bedside we also carry out Research and development on clinical and experimental medical technology which are directed at optical spectroscopy of tissue and mitochondrial oxygenation and clinical microcirculation imaging