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Our studies focus on members of the enzyme family known as ‘2OG dioxygenases’. These versatile enzymes catalyze hydroxylation of proteins, nucleic acids and small molecules. We study 2OG dioxygenases associated with obesity. 

Research interests:

• The function of the fat-mass and obesity associated protein ('FTO'): the strongest known genetic predictor for obesity.
• The role of post-translational modifications on the oligomeric state of the metabolic hormone adiponectin.
• Structural and functional analysis of proteins, including protein dynamics, protein-protein interactions and characterization of ligand binding sites.
• Protein homology modelling and structure prediction, ligand-docking studies.