Research interests

HIV replication and anti-viral strategies

This research line includes both basic and applied HIV research, which are intermingled and complement each other.

Basic research focuses on:
1. The structure and function of the HIV genome. In particular, we investigate the structure of the viral RNA and its role in different replication steps, such as transcription, RNA splicing, dimerization and packaging.
2. The role of the viral Tat protein in HIV replication.

Applied research focuses on:
1. Novel strategies to inhibit HIV replication (based on the CRISPR/Cas9 system and RNA interference mechanism).
2. Development of conditionally replicating HIV variants as a novel approach toward a safe live-attenuated HIV vaccine and as a tool to study the host (immune) responses that correlate with protection induced by live-attenuated virus vaccines.
3. The use of viral evolution as a tool to develop new gene expression systems (Tet-On systems).
 

specialisation

Molecular biology of human immunodeficiency virus (HIV)

Research output

  1. Mutations in the HIV-1 3-Polypurine Tract Can Confer Dolutegravir Resistance

    Research output: Contribution to journalComment/Letter to the editorAcademic

  2. Transient crispr-cas treatment can prevent reactivation of hiv-1 replication in a latently infected t-cell line

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Variations in the abortive hiv-1 rna hairpin do not impede viral sensing and innate immune responses

    Research output: Contribution to journalArticleAcademicpeer-review

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