Research interests

Dr. Verkerk, member of the "Cardiac Pacemaker" group of the Heart Failure Research Center (HFRC), is working on basic mechanisms of cardiac electrical activity, excitation-contraction coupling, arrhythmias, and heart failure, with particular emphasis on cardiac ion channels, ion exchangers and impulse propagation. His deep and integrative understanding of cellular electrophysiology and ion transport systems is essential for the multidisciplinary cardiovascular research of the recently formed Heart Failure Research Center (HFRC). Specifically, Dr. Verkerk’s expertise covers a wide range of the functional aspects of the various cardiac cell types and constitutes the link between ‘clone’ (molecular biology, proteomics, genetics, cardiac embryology) and ‘clinic’. Accordingly, research is conducted in close collaboration with basic scientists on one hand and clinicians on the other hand.
Dr. Verkerk’s current research work is focused on basic mechanisms of cardiac pacemaking. Using sophisticated and novel techniques for ion channel function studies (e.g. dynamic action potential clamp), mathematical cell models, and various transgenic mouse models, the molecular and cellular mechanisms of cardiac pacemaking are studied during development, aging and disease.

specialisation

Research output

  1. Aquaporin Channels in the Heart-Physiology and Pathophysiology

    Research output: Contribution to journalReview articleAcademicpeer-review

  2. Cardiomyocyte progenitor cells as a functional gene delivery vehicle for long-term biological pacing

    Research output: Contribution to journalArticleAcademicpeer-review

  3. Acetylcholine Delays Atrial Activation to Facilitate Atrial Fibrillation

    Research output: Contribution to journalArticleAcademicpeer-review

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